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1.
公开(公告)号:US08329170B2
公开(公告)日:2012-12-11
申请号:US13299831
申请日:2011-11-18
申请人: Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人: Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号: A61K39/395
CPC分类号: C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体,其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列,包括编码至少一种抗IL-12抗体,载体,宿主细胞,转基因动物或植物的分离的核酸,以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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2.
公开(公告)号:US08323646B2
公开(公告)日:2012-12-04
申请号:US12539630
申请日:2009-08-12
申请人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
发明人: Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要: The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译: 本发明涉及针对人白细胞介素-13(IL-13)蛋白或其片段免疫特异性的工程化抗体,以及其制备和使用方法,包括治疗适应症。
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公开(公告)号:US20120282170A1
公开(公告)日:2012-11-08
申请号:US13547557
申请日:2012-07-12
IPC分类号: A61K39/395 , C12N15/63 , C12N5/10 , C12P21/02 , C07K16/42 , C12N5/071 , G01N33/566 , A61K51/00 , C12N1/00 , G01N33/577 , A61P29/00 , A61P21/02 , A61P23/00 , A61P25/20 , A61P31/00 , A61P17/06 , A61P37/04 , A61P37/06 , A61P25/24 , A61P25/18 , A61P11/06 , C12N15/13
CPC分类号: C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
摘要翻译: 本发明涉及包含SEQ ID NO:1,2和3的所有重链可变CDR区和/或SEQ ID NO:4,5和6的所有轻链可变CDR区的抗TNF抗体, 特异于至少一种人肿瘤坏死因子α(TNF)蛋白或其片段,以及编码这种抗TNF抗体的核酸,互补核酸,载体,宿主细胞,生产方法和治疗方法。
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4.
公开(公告)号:US20120207670A1
公开(公告)日:2012-08-16
申请号:US13299831
申请日:2011-11-18
申请人: Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人: Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号: A61K39/395 , A61P29/00 , A61P23/00 , A61P37/00 , A61P37/04 , A61P5/00 , A61P37/06 , A61P23/02 , A61K51/00 , A61P21/00 , A61P21/02 , A61P25/20 , A61P17/06 , A61P31/00
CPC分类号: C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体,其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列,包括编码至少一种抗IL-12抗体,载体,宿主细胞,转基因动物或植物的分离的核酸,以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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公开(公告)号:US07955597B2
公开(公告)日:2011-06-07
申请号:US12507962
申请日:2009-07-23
申请人: Jill Giles-Komar , David Knight , David Peritt , Mohit Trikha
发明人: Jill Giles-Komar , David Knight , David Peritt , Mohit Trikha
IPC分类号: A61K39/395
CPC分类号: C07K16/248 , A01K67/0271 , A01K2267/0331 , A61K39/3955 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要: The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译: 本发明涉及至少一种衍生自鼠CLB-8抗体的新型嵌合,人源化或CDR移植的抗IL-6抗体,包括编码至少一种这样的抗IL-6抗体的分离的核酸,载体, 宿主细胞,转基因动物或植物,以及其制备和使用方法,包括治疗组合物,方法和装置。
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公开(公告)号:US20110082190A1
公开(公告)日:2011-04-07
申请号:US12971626
申请日:2010-12-17
IPC分类号: A61K31/7088 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/02 , A61P37/00 , A61P9/00 , A61P31/00 , A61P35/00 , A61P25/00 , C12N1/00
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.
摘要翻译: 分离的抗IL-12抗体,编码抗体或抗体部分的核酸,载体,宿主细胞和制备方法可用于产生抗体或用于治疗和/或诊断IL-12相关病症和疾病的部分。
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公开(公告)号:US07820169B2
公开(公告)日:2010-10-26
申请号:US12268955
申请日:2008-11-11
IPC分类号: A61K39/395 , A61K31/573 , A61K49/00 , C07K16/00
CPC分类号: C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要: The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable region of SEQ ID NO:8, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof.
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公开(公告)号:US20090217392A1
公开(公告)日:2009-08-27
申请号:US12426996
申请日:2009-04-21
申请人: Jill Giles-Komar , Linda Snyder , Mohit Trikha , Marian T. Nakada
发明人: Jill Giles-Komar , Linda Snyder , Mohit Trikha , Marian T. Nakada
CPC分类号: C07K16/2839 , A01K2217/05 , A01K2267/01 , A61K2039/505 , C07K16/2848 , C07K16/4258 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/5008 , G01N33/5029 , G01N33/68 , G01N2333/70546 , Y02A50/58
摘要: The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译: 本发明涉及至少一种新的抗α-V亚基抗体,包括编码至少一种抗-α-V亚基抗体,α-V亚基,载体,宿主细胞,转基因动物或植物的分离的核酸,以及 制备和使用它们的方法,包括治疗组合物,方法和装置。
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9.
公开(公告)号:US20090202549A1
公开(公告)日:2009-08-13
申请号:US11722312
申请日:2005-12-20
申请人: Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人: Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号: A61K39/395 , G01N33/53 , C12P21/04 , C12N5/10 , C12N5/02 , C12N15/63 , C07K16/24 , C07H21/04
CPC分类号: C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体,其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列,包括编码至少一种抗IL-12抗体,载体,宿主细胞,转基因动物或植物的分离的核酸,以及制备方法 并且其使用在诊断和/或治疗组合物,方法和装置中具有应用。
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公开(公告)号:US20090193529A1
公开(公告)日:2009-07-30
申请号:US12369958
申请日:2009-02-12
IPC分类号: C12P21/00
摘要: Methods for generating antibodies in rodents are disclosed. The antibodies are useful as therapeutic agents, diagnostic agents or research reagents.
摘要翻译: 公开了在啮齿动物中产生抗体的方法。 抗体可用作治疗剂,诊断剂或研究试剂。
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