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公开(公告)号:US08633187B2
公开(公告)日:2014-01-21
申请号:US13411887
申请日:2012-03-05
Applicant: Steven David Knight , Stanley J. Schmidt
Inventor: Steven David Knight , Stanley J. Schmidt
IPC: A61K31/4709 , A61K31/5383 , A61K31/5377 , A61K31/549
CPC classification number: C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
Abstract translation: 本发明是使用喹啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过给药喹啉衍生物的移植物排斥反应和肺损伤。
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公开(公告)号:US20100234386A1
公开(公告)日:2010-09-16
申请号:US12599544
申请日:2008-05-08
Applicant: Amita Chaudhari , Dashyant Dhanak , Carla Ann Donatelli , Thomas H. Faitg , Yanhong Feng , Steven David Knight , Cynthia A. Parrish , Jeffrey M. Ralph , Martha A. Sarpong , Domingos J. Silva
Inventor: Amita Chaudhari , Dashyant Dhanak , Carla Ann Donatelli , Thomas H. Faitg , Yanhong Feng , Steven David Knight , Cynthia A. Parrish , Jeffrey M. Ralph , Martha A. Sarpong , Domingos J. Silva
IPC: A61K31/498 , C07D401/02 , A61P29/00 , A61P9/00 , A61P25/00 , A61P11/06 , A61P13/12 , A61P35/00 , A61P15/00
CPC classification number: C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/14
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
Abstract translation: 发明的是使用喹喔啉衍生物抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用喹喔啉衍生物的移植排斥和肺部损伤。
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公开(公告)号:US07629477B2
公开(公告)日:2009-12-08
申请号:US12142621
申请日:2008-06-19
Applicant: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
Inventor: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC: C07D311/22
CPC classification number: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号:US20090082349A1
公开(公告)日:2009-03-26
申请号:US12281187
申请日:2007-03-02
Applicant: Dashyant Dhanak , Steven David Knight
Inventor: Dashyant Dhanak , Steven David Knight
IPC: A61K31/5377 , A61K31/517 , A61K31/502 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/00 , A61P35/00
CPC classification number: A61K31/5377
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
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公开(公告)号:US20090048252A1
公开(公告)日:2009-02-19
申请号:US12281181
申请日:2007-03-02
Applicant: Dashyant Dhanak , Steven David Knight
Inventor: Dashyant Dhanak , Steven David Knight
IPC: A61K31/427 , A61K31/5377 , A61K31/496 , A61K31/454
CPC classification number: A61K31/5377
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
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公开(公告)号:US20090023742A1
公开(公告)日:2009-01-22
申请号:US12281179
申请日:2007-03-02
Applicant: Dashyant Dhanak , Steven David Knight
Inventor: Dashyant Dhanak , Steven David Knight
IPC: A61K31/498 , A61K31/426 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/496 , A61P29/00 , A61P25/00 , A61P11/06 , A61P19/02 , A61P13/12 , A61P35/00 , A61P9/00 , A61P37/02 , A61K31/437 , A61K31/454 , A61K31/428 , A61K31/4709
CPC classification number: A61K31/496
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
Abstract translation: 发明了使用取代的噻唑啉酮抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用取代的噻唑啉酮的移植物排斥和肺损伤。
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公开(公告)号:US20080255115A1
公开(公告)日:2008-10-16
申请号:US11844404
申请日:2007-08-24
Applicant: Michael Gerard Darcy , Steven David Knight , Nicholas D. Adams , Stanley J. Schmidt
Inventor: Michael Gerard Darcy , Steven David Knight , Nicholas D. Adams , Stanley J. Schmidt
IPC: C07D401/14 , A61K31/4709 , A61K31/497 , A61K31/501 , C07D413/14 , A61K31/5377 , A61P35/00
CPC classification number: C07D417/14
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives.
Abstract translation: 本发明是使用噻唑烷二酮衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用噻唑烷二酮衍生物的移植排斥和肺损伤。
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公开(公告)号:US07166595B2
公开(公告)日:2007-01-23
申请号:US10429195
申请日:2003-05-02
Applicant: Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
Inventor: Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
IPC: C07D239/36 , A61K31/513 , A61K31/517 , C07D239/70
CPC classification number: C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号:US06544992B1
公开(公告)日:2003-04-08
申请号:US10149793
申请日:2002-06-13
Applicant: Dashyant Dhanak , Steven David Knight , Jian Jin , Richard McCulloch Keenan
Inventor: Dashyant Dhanak , Steven David Knight , Jian Jin , Richard McCulloch Keenan
IPC: A61K315377
CPC classification number: C07D401/10 , C07D207/14 , C07D211/56
Abstract: The present invention relates to pyrrolyl and pyridyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of urotensin II.
Abstract translation: 本发明涉及吡咯基和吡啶基衍生物,含有它们的药物组合物及其作为尿路保护素II抑制剂的用途。
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公开(公告)号:US08633236B2
公开(公告)日:2014-01-21
申请号:US13612686
申请日:2012-09-12
Applicant: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
Inventor: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC: A61K31/4164
CPC classification number: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
Abstract translation: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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