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公开(公告)号：US08633236B2
公开(公告)日：2014-01-21
申请号：US13612686
申请日：2012-09-12
Applicant: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
Inventor： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC: A61K31/4164
CPC classification number: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
Abstract translation: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20130053436A1
公开(公告)日：2013-02-28
申请号：US13612686
申请日：2012-09-12
Applicant: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, JR. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
Inventor： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, JR. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC: A61K31/352 , A61P35/00
CPC classification number: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
Abstract translation: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US08138347B2
公开(公告)日：2012-03-20
申请号：US12121891
申请日：2008-05-16
Applicant: Steven David Knight , Stanley J. Schmidt
Inventor： Steven David Knight , Stanley J. Schmidt
IPC: C07D285/24 , C07D401/14 , C07D413/14
CPC classification number: C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
Abstract translation: 本发明是使用喹啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过给药喹啉衍生物的移植物排斥反应和肺损伤。
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公开(公告)号：US07919524B2
公开(公告)日：2011-04-05
申请号：US12582424
申请日：2009-10-20
Applicant: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
Inventor： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC: A61K31/353
CPC classification number: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
Abstract translation: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20100152112A1
公开(公告)日：2010-06-17
申请号：US12600745
申请日：2008-05-16
Applicant: Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight
Inventor： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight
IPC: A61K31/4709 , C07D401/14 , C07D413/14 , C07D498/04 , A61K31/5377 , A61K31/5383 , A61K38/22 , A61P35/00 , A61P25/00 , A61P9/00 , A61P1/00 , A61P19/02
CPC classification number: C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
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Patent Agency Ranking
公开(公告)号：US20090306074A1
公开(公告)日：2009-12-10
申请号：US12296708
申请日：2007-04-11
Applicant: Michael Gerard Darcy , Steven David Knight , Nicholas D. Adams , Stanley J. Schmidt
Inventor： Michael Gerard Darcy , Steven David Knight , Nicholas D. Adams , Stanley J. Schmidt
IPC: A61K31/4709 , C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/501 , A61P29/00 , A61P9/00 , A61P11/00
CPC classification number: C07D417/14
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives.
Abstract translation: 本发明是使用噻唑烷二酮衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用噻唑烷二酮衍生物的移植排斥和肺损伤。
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公开(公告)号：US07528137B2
公开(公告)日：2009-05-05
申请号：US11262506
申请日：2005-10-27
Applicant: Bainian Feng , Gustave Bergnes , David J. Morgans, Jr. , Dashyant Dhanak , Steven David Knight , Michael Gerard Darcy
Inventor： Bainian Feng , Gustave Bergnes , David J. Morgans, Jr. , Dashyant Dhanak , Steven David Knight , Michael Gerard Darcy
IPC: C07D271/02 , C07D291/00 , C07D239/70
CPC classification number: C07D403/06
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
Abstract translation: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US07491746B2
公开(公告)日：2009-02-17
申请号：US11154989
申请日：2005-06-15
Applicant: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
Inventor： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC: A61K31/353
CPC classification number: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
Abstract translation: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20090018131A1
公开(公告)日：2009-01-15
申请号：US12137561
申请日：2008-06-12
Applicant: Nicholas D. ADAMS , Joelle Lorraine BURGESS , Michael Gerard DARCY , Steven David KNIGHT , Kenneth Allen NEWLANDER , Lance H. RIDGERS , Stanley J. SCHMIDT
Inventor： Nicholas D. ADAMS , Joelle Lorraine BURGESS , Michael Gerard DARCY , Steven David KNIGHT , Kenneth Allen NEWLANDER , Lance H. RIDGERS , Stanley J. SCHMIDT
IPC: A61K31/517 , A61K31/5377 , C07D401/14 , C07D413/14 , A61P25/00 , A61P35/00 , A61P35/02 , A61P9/00
CPC classification number: A61K31/5377 , A61K31/517 , C07D401/04 , C07D401/14 , C07D471/04
Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinazoline derivatives.
Abstract translation: 发明了使用喹唑啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用喹唑啉衍生物的移植物排斥和肺损伤。
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公开(公告)号：US20090005580A1
公开(公告)日：2009-01-01
申请号：US12142621
申请日：2008-06-19
Applicant: Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, JR. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
Inventor： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, JR. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC: C07D311/74
CPC classification number: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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