公开(公告)号：US4049811A

公开(公告)日：1977-09-20

申请号：US676269

申请日：1976-04-12

申请人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16 ,  A61K31/47

CPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16

摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1##wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

摘要翻译： 具有以下结构式表征的抗微生物活性的环烷醇 - 喹诺酮衍生物：其中R 1和R 2之一表示氢，卤素，硝基，氨基，羟基，酰氨基，酰氧基，烷氧基或芳氧基，另一个与R 3一起形成 含有2至6个碳原子的亚烷基桥，X是氢，可以被卤素，羟基，酰氧基，烷氧基，芳氧基，芳烷氧基，巯基，烷基巯基，芳基巯基，芳基磺酰基和烷基磺酰基中的成员所取代的低级烷基 或X为未取代的烯基，包括链二烯基或炔基，Y为羟基，氨基或低级烷氧基，及其药学上可接受的盐。

公开(公告)号：US4034096A

公开(公告)日：1977-07-05

申请号：US595953

申请日：1975-07-14

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物 或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US4006141A

公开(公告)日：1977-02-01

申请号：US601116

申请日：1975-07-31

申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

摘要翻译： 具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪：其中R是氢或在2-位被羟基或低级酰氧基或低级烷氧基任选取代的低级烷基; A是氢，卤素，叠氮基，氰基; 低级烷基烷氧基，烷硫基，烷基磺酰基，羧基; 低级烷氧基羰基，低级烷氧羰基亚氨基; 或肼基，氨基甲酰基，脒基或任选被一个或两个低级酰基，烷基或环烷基取代的碳代酰肼基; 或者A是下式的基团：其中R 1和R 2分别是氢或多个有机基团，或者一起可以是亚烷基桥; 并且R 3是氢或低级烷基; 或者与R 2一起形成亚烷基桥; N IS 0或1; 并且与药物相容，作为抗病毒药物具有高度的生物有效性。

公开(公告)号：US3966743A

公开(公告)日：1976-06-29

申请号：US504589

申请日：1974-09-09

申请人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16 ,  C07D221/08 ,  C07D221/10

摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##SPC1##Wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an akylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

摘要翻译： 具有抗细菌活性的环烷醇 - 喹诺酮衍生物，其特征在于下式：

公开(公告)号：US3948912A

公开(公告)日：1976-04-06

申请号：US559285

申请日：1975-03-17

申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

IPC分类号： C07D403/14 ,  A61K31/5025 ,  C07D487/04 ,  C07D237/26

CPC分类号： C07D487/04

摘要： New nitroimidazolyl-triazolo-pyridazines of the formula: ##SPC1##WhereinZ is methyl or amino which can be substituted by lower alkyl,And the pharmacologically compatible acid-addition salts thereof, exhibit outstanding anti-microbial activity against bacteria and protozoa, and also systemic effectiveness.

摘要翻译： 新的具有下式的硝基咪唑基 - 三唑并 - 哒嗪：

公开(公告)号：US4835280A

公开(公告)日：1989-05-30

申请号：US72917

申请日：1987-07-14

申请人： Alfred Martens ,  Jens-Peter Holck ,  Herbert Berger ,  Bernd Muller-Beckman ,  Klaus Strein ,  Egon Roesch

发明人： Alfred Martens ,  Jens-Peter Holck ,  Herbert Berger ,  Bernd Muller-Beckman ,  Klaus Strein ,  Egon Roesch

IPC分类号： C07D403/12 ,  C07D405/12 ,  C07D487/04

CPC分类号： C07D403/12 ,  C07D405/12 ,  C07D487/04

摘要： The present invention provides Indolines of the formula: ##STR1## ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.

摘要翻译： 本发明提供下式的吲哚衍生物：下式的有用的药物活性吡咯并苯并咪唑或其互变异构体：（I）这些化合物可用于治疗心脏或 循环系统疾病，特别是那些对血压变化作出反应，心输出量增加和/或微循环变化的疾病。

公开(公告)号：US4410532A

公开(公告)日：1983-10-18

申请号：US334614

申请日：1981-12-28

申请人： Elmar Bosies ,  Herbert Berger ,  Wolfgang Kampe ,  Uwe Bicker ,  Alfred Grafe

发明人： Elmar Bosies ,  Herbert Berger ,  Wolfgang Kampe ,  Uwe Bicker ,  Alfred Grafe

IPC分类号： C07D203/08 ,  A61K31/395 ,  A61K31/396 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61P37/04 ,  C07D203/06 ,  C07D401/04 ,  C07D403/06 ,  C07D405/04 ,  C07D409/04 ,  C07D213/36

CPC分类号： C07D203/06 ,  Y10S514/885

摘要： A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy;or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.

摘要翻译： 具有式“IMAGE”的2-氰基氮丙啶衍生物，其中R'是具有至多8个碳原子的直链或支链，饱和或单或多不饱和脂族烃基，其被含芳族含氮杂环基团取代， 5或6个环成员和1,2或3个任选被卤素取代的氮原子，具有至多8个碳原子的烷氧基，至多8个碳原子的烷基，羟基，至多9个碳原子的烷氧基，氨基甲酰基，二烷基氨基烷基 其具有至多8个碳原子的部分，环烷基氨基，具有3-10个碳原子的环烷基部分，乙酰氨基，硝基，氰基，乙酰基，具有至多8个碳原子的烷硫基，具有至多8个碳原子的烷基亚磺酰基，烷基磺酰基， 8个碳原子，氨磺酰基，苯基，三氟甲基，苯氧基，乙酰氧基或亚甲二氧基; 或其药理学上可接受的盐显示免疫刺激活性。

公开(公告)号：US3995040A

公开(公告)日：1976-11-30

申请号：US595929

申请日：1975-07-14

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##SPC1##WhereinR is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 式WHEREIN R的新的环戊烯 - 喹诺酮衍生物是饱和或不饱和的脂族烃基，例如烷基和烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代或取代的（ 例如烷基单取代或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US08388312B2

公开(公告)日：2013-03-05

申请号：US12605604

申请日：2009-10-26

申请人： Bernd Hollnbuchner ,  Herbert Berger ,  Daniel Fischer

发明人： Bernd Hollnbuchner ,  Herbert Berger ,  Daniel Fischer

IPC分类号： F04D29/30

CPC分类号： F02C7/045 ,  F04D29/4213 ,  F04D29/665 ,  F04D29/681 ,  F04D29/685 ,  F05D2220/40 ,  F05D2250/291 ,  F05D2250/71

摘要： A compressor for an exhaust gas turbocharger includes an exhaust gas turbocharger housing having a gas intake port, which substantially radially encloses a gas inflow area. Disposed in the exhaust gas turbocharger housing is a compressor wheel, which can be driven by an exhaust gas turbine. The compressor wheel bounds the gas inflow area in the gas intake port in the direction of flow of a gas. The gas intake port includes indentations on a side of the inflow area. The flow noise in normal operation of the compressor and the acoustic effect in the case of pumping are reduced with the indentations.

摘要翻译： 一种用于排气涡轮增压器的压缩机包括具有气体进气口的废气涡轮增压器壳体，其基本上径向包围气体流入区域。 设置在废气涡轮增压器壳体中的是可由排气涡轮机驱动的压缩机叶轮。 压缩机叶轮沿着气体的流动方向限制进气口中的气体流入区域。 进气口在流入区域的一侧包括压痕。 在压缩机的正常运行中的流动噪声和在泵送情况下的声学效应随压痕而减小。

公开(公告)号：US20100111676A1

公开(公告)日：2010-05-06

申请号：US12605604

申请日：2009-10-26

申请人： Bernd HOLLNBUCHNER ,  Herbert BERGER ,  Daniel FISCHER

发明人： Bernd HOLLNBUCHNER ,  Herbert BERGER ,  Daniel FISCHER

IPC分类号： F04D13/12

CPC分类号： F02C7/045 ,  F04D29/4213 ,  F04D29/665 ,  F04D29/681 ,  F04D29/685 ,  F05D2220/40 ,  F05D2250/291 ,  F05D2250/71

摘要： A compressor for an exhaust gas turbocharger includes an exhaust gas turbocharger housing having a gas intake port, which substantially radially encloses a gas inflow area. Disposed in the exhaust gas turbocharger housing is a compressor wheel, which can be driven by an exhaust gas turbine. The compressor wheel bounds the gas inflow area in the gas intake port in the direction of flow of a gas. The gas intake port includes indentations on a side of the inflow area. The flow noise in normal operation of the compressor and the acoustic effect in the case of pumping are reduced with the indentations.

摘要翻译： 一种用于排气涡轮增压器的压缩机包括具有气体进气口的废气涡轮增压器壳体，其基本上径向包围气体流入区域。 设置在废气涡轮增压器壳体中的是可由排气涡轮机驱动的压缩机叶轮。 压缩机叶轮沿着气体的流动方向限制进气口中的气体流入区域。 进气口在流入区域的一侧包括压痕。 在压缩机的正常运行中的流动噪声和在泵送情况下的声学效应随压痕而减小。