公开(公告)号：US3995040A

公开(公告)日：1976-11-30

申请号：US595929

申请日：1975-07-14

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##SPC1##WhereinR is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 式WHEREIN R的新的环戊烯 - 喹诺酮衍生物是饱和或不饱和的脂族烃基，例如烷基和烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代或取代的（ 例如烷基单取代或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US4049811A

公开(公告)日：1977-09-20

申请号：US676269

申请日：1976-04-12

申请人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16 ,  A61K31/47

CPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16

摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1##wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

摘要翻译： 具有以下结构式表征的抗微生物活性的环烷醇 - 喹诺酮衍生物：其中R 1和R 2之一表示氢，卤素，硝基，氨基，羟基，酰氨基，酰氧基，烷氧基或芳氧基，另一个与R 3一起形成 含有2至6个碳原子的亚烷基桥，X是氢，可以被卤素，羟基，酰氧基，烷氧基，芳氧基，芳烷氧基，巯基，烷基巯基，芳基巯基，芳基磺酰基和烷基磺酰基中的成员所取代的低级烷基 或X为未取代的烯基，包括链二烯基或炔基，Y为羟基，氨基或低级烷氧基，及其药学上可接受的盐。

公开(公告)号：US4034096A

公开(公告)日：1977-07-05

申请号：US595953

申请日：1975-07-14

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物 或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US3966743A

公开(公告)日：1976-06-29

申请号：US504589

申请日：1974-09-09

申请人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16 ,  C07D221/08 ,  C07D221/10

摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##SPC1##Wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an akylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

摘要翻译： 具有抗细菌活性的环烷醇 - 喹诺酮衍生物，其特征在于下式：

公开(公告)号：US4033967A

公开(公告)日：1977-07-05

申请号：US515790

申请日：1974-10-17

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D215/20 ,  A61K31/473 ,  C07D215/06 ,  C07D215/233 ,  C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物 或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US3988460A

公开(公告)日：1976-10-26

申请号：US558101

申请日：1975-03-13

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, executor ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, executor ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： A61K31/47

CPC分类号： A61K31/47

摘要： Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1##WhereinR and X, which may be the same or different, are hydrogen or lower saturated or unsaturated aliphatic hydrocarbyl;Y is hydroxyl or lower alkoxy or lower acyloxy (i.e., alkanoyloxy); andZ is hydrogen or lower alkoxy, or, together with Y, represents an oxo or lower alkenyldioxy radical; and the pharmacologically compatibile salts thereofAre outstandingly effective as anti-microbials, particularly for applications against infections of the urinary tract.

摘要翻译： 某些新的环戊烯喹诺酮衍生物，其结构如下：

公开(公告)号：US3957766A

公开(公告)日：1976-05-18

申请号：US290682

申请日：1972-09-20

申请人： Herbert Berger ,  Rudi Gall ,  Hartmut Merdes ,  Kurt Stach ,  Winfriede Sauer ,  Wolfgang Vomel

发明人： Herbert Berger ,  Rudi Gall ,  Hartmut Merdes ,  Kurt Stach ,  Winfriede Sauer ,  Wolfgang Vomel

IPC分类号： C07D487/04 ,  C07D295/06 ,  C07D295/12 ,  C07D471/04

CPC分类号： C07D487/04

摘要： Certain novel nitrofuran compounds of the formula: ##SPC1##WhereinHet is an aromatic heterocylic linkage;B is a bond or vinylene;Y is O or S;m is 0 or 1;X is hydrogen, lower alkyl or alkanoyl; andThe R's are variously defined;Are outstandingly effective bacteriostats and bactericides.

公开(公告)号：US3962242A

公开(公告)日：1976-06-08

申请号：US545661

申请日：1975-01-30

申请人： Herbert Berger ,  Rudi Gall ,  Max Thiel ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Herbert Berger ,  Rudi Gall ,  Max Thiel ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D487/04 ,  C07D237/26

CPC分类号： C07D487/04

摘要： Nitrofuryl-triazolo[4,3-b]pyridazine compounds of the formula ##SPC1##WhereinR.sub.1 is lower alkoxy radical or a saturated 5- or 6-membered heterocyclic ring attached via a cyclic nitrogen atom, which heterocyclic ring can also contain, in addition to said cyclic nitrogen atom, a cyclic oxygen atom or an optionally lower alkylated cyclic nitrogen atom and R.sub.2 is a hydrogen atom or R.sub.1 and R.sub.2 together represent an additional valency bond,Are outstandingly effective as bacteriostats and are particularly useful in the treatment of bacterial infections in the urinary tract.