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公开(公告)号：US20220031652A1
公开(公告)日：2022-02-03
申请号：US17292689
申请日：2019-11-12
IPC分类号： A61K31/295 , A61P35/02
摘要： Disclosed is the non-therapeutic use, as a DNA-demethylating agent, of at least one organometallic compound including an iron atom bound to two terpyridine groups. Further disclosed are method related to applying such agent as medicine.
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公开(公告)号：US20210361759A1
公开(公告)日：2021-11-25
申请号：US17392066
申请日：2021-08-02
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Institut Pasteur de Lille , National University of Ireland Maynooth
发明人： Camille Locht , Bernard Mahon , Heather Kavanagh
摘要： The present invention relates to a live attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology.
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公开(公告)号：US11110161B2
公开(公告)日：2021-09-07
申请号：US16840276
申请日：2020-04-03
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Institut Pasteur de Lille , National University of Ireland Maynooth
发明人： Camille Locht , Bernard Mahon , Heather Kavanagh
摘要： The present invention relates to a live attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology.
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公开(公告)号：US20210169935A1
公开(公告)日：2021-06-10
申请号：US17173668
申请日：2021-02-11
申请人： Assistance Publique - Hopitaux de Paris , Fondation Imagine - Institut des Maladies Génétiques , Université de Paris , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen
IPC分类号： A61K35/17 , C12N5/0783
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
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公开(公告)号：US20200171139A1
公开(公告)日：2020-06-04
申请号：US16787767
申请日：2020-02-11
IPC分类号： A61K39/02
摘要： A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
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公开(公告)号：US20200157225A1
公开(公告)日：2020-05-21
申请号：US16773192
申请日：2020-01-27
IPC分类号： C07K16/28 , C12N15/113 , A61P35/02 , G01N33/50
摘要： The present invention relates to an inhibitor of H3K9 histone methyl transferase SUV39H1 for use in combination with at least one immune checkpoint modulator in the treatment of cancer.
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公开(公告)号：US10385125B2
公开(公告)日：2019-08-20
申请号：US15451268
申请日：2017-03-06
申请人： LES LABORATOIRES SERVIER , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： A61K39/00 , C07K16/26 , G01N33/574
摘要： The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.
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公开(公告)号：US20180369331A1
公开(公告)日：2018-12-27
申请号：US15739238
申请日：2016-06-24
申请人： Universite Claude Bernard Lyon 1 , Institut National De La Recherche Argronomique (INRA) , Institut National De La Santé Et De La Recherche Médicale (INSERM) , Bergen Teknologioverforing AS
摘要： The present invention relates to a FGF19 polypeptide for its use as an agent increasing muscle fibers size, in the prevention and/or treatment of muscle atrophy in a mammal body.
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公开(公告)号：US10046044B2
公开(公告)日：2018-08-14
申请号：US15477562
申请日：2017-04-03
申请人： National University of Singapore , Institut Pasteur de Lille , Institut National de la Santé et de la Recherche Médicale (INSERM)
摘要： A CyaA-deficient B. pertussis mutant was constructed and used in a vaccine. The pertussis-specific antibody profile and Th17 response induced by vaccination with the mutant was surprisingly comparable to that induced by B. pertussis strains not deficient in CyaA.
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20.发明申请公开(公告)号：US20180142012A1
公开(公告)日：2018-05-24
申请号：US15831134
申请日：2017-12-04
申请人： Centre National de la Recherche Scientifique , Collège de France , Institut National de la Santé et de la Recherche Médicale (INSERM)
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K39/0007 , A61K48/00 , A61K2039/54 , C07K2317/622 , C07K2317/76 , C12N15/113 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to the treatment of neurodegenerative diseases, in particular Alzheimer's disease, by inhibition of the synthesis of βAPP or of the activity of the Aβ peptide in the choroid plexus.
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