-
公开(公告)号：US20200046767A1
公开(公告)日：2020-02-13
申请号：US16485488
申请日：2018-02-12
申请人： Assistance Publique - Hopitaux de Paris , Fondation Imagine - Institut des Maladies Génétiques , Université Paris Descartes , Institut National de la Santé et de la Recherche Médicale
发明人： Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen
IPC分类号： A61K35/17 , C12N5/0783
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
公开(公告)号：US11642376B2
公开(公告)日：2023-05-09
申请号：US17173668
申请日：2021-02-11
申请人： Assistance Publique—Hopitaux de Paris , Fondation Imagine—Institut des Maladies Génétiques , Université Paris Cité , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen , Tayebeh-Shabi Soheili , Ranjita Devi Moirangthem
IPC分类号： A61K48/00 , C12N5/00 , A61K35/17 , C12N5/0783 , A01K67/00
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/125 , C12N2501/145 , C12N2501/2307 , C12N2501/25 , C12N2501/26 , C12N2501/42 , C12N2506/11 , C12N2533/52
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
公开(公告)号：US11426430B2
公开(公告)日：2022-08-30
申请号：US17010208
申请日：2020-09-02
申请人： Assistance Publique—Hopitaux de Paris , Fondation Imagine—Institut des Maladies Génétiques , Université de Paris Cité , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen , Tayebeh-Shabi Soheili , Ranjita Devi Moirangthem
IPC分类号： C12N5/00 , C12N5/02 , A61K35/17 , C12N5/0783 , A61K48/00
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
公开(公告)号：US20210169934A1
公开(公告)日：2021-06-10
申请号：US17173632
申请日：2021-02-11
申请人： Assistance Publique - Hopitaux de Paris , Fondation Imagine - Institut des Maladies Génétiques , Université de Paris , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen
IPC分类号： A61K35/17 , C12N5/0783
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
公开(公告)号：US20230293586A1
公开(公告)日：2023-09-21
申请号：US18296623
申请日：2023-04-06
申请人： Assistance Publique - Hopitaux de Paris , Fondation Imagine - Institut des Maladies Génétiques , Université Paris Cité , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle ANDRÉ , Marina CAVAZZANA , Kuiying MA , John TCHEN , Tayebeh-Shabi SOHEILI , Ranjita Devi MOIRANGTHEM
IPC分类号： A61K35/17 , C12N5/0783
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/125 , C12N2501/145 , C12N2501/2307 , C12N2501/25 , C12N2501/26 , C12N2501/42 , C12N2506/11 , C12N2533/52
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
公开(公告)号：US11638723B2
公开(公告)日：2023-05-02
申请号：US17173632
申请日：2021-02-11
申请人： Assistance Publique—Hopitaux de Paris , Fondation Imagine—Institut des Maladies Génétiques , Université Paris Cité , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen , Tayebeh-Shabi Soheili , Ranjita Devi Moirangthem
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
公开(公告)号：US20210169935A1
公开(公告)日：2021-06-10
申请号：US17173668
申请日：2021-02-11
申请人： Assistance Publique - Hopitaux de Paris , Fondation Imagine - Institut des Maladies Génétiques , Université de Paris , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen
IPC分类号： A61K35/17 , C12N5/0783
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.017 秒)
