-
公开(公告)号：US12054778B2
公开(公告)日：2024-08-06
申请号：US17161171
申请日：2021-01-28
申请人： PML Screening, LLC , The Université Paris-Saclay , The Assistance Publique—Hôpitaux de Paris (APHP) , The Institut National de la Santé et de la Recherche Médicale (INSERM)
IPC分类号： C12Q1/6883
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.
-
公开(公告)号：US20240158797A1
公开(公告)日：2024-05-16
申请号：US18281642
申请日：2022-03-18
申请人： UNIVERSITÉ GRENOBLE ALPES , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE
IPC分类号： C12N15/113 , A61K31/166 , A61K31/175 , A61K31/282 , A61K31/495 , A61P35/00
CPC分类号： C12N15/1137 , A61K31/166 , A61K31/175 , A61K31/282 , A61K31/495 , A61P35/00 , C12N2310/11
摘要： An antisense oligonucleotides having the ability to decrease the expression level of the huntingtin protein in glioma cells, for their use in sensitizing the cells to an anti-cancer treatment.
-
公开(公告)号：US20240092858A1
公开(公告)日：2024-03-21
申请号：US18255951
申请日：2020-12-08
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
发明人： Christina Zeitz , Deniz Dalkara , Juliette Varin , Isabelle Audo , Serge Picaud , José-Alain Sahel
IPC分类号： C07K14/705 , A61K48/00 , A61P27/02 , C12N15/86
CPC分类号： C07K14/70503 , A61K48/0058 , A61P27/02 , C12N15/86 , C12N2750/14143 , C12N2830/008 , C12N2830/48
摘要： The present invention relates to an expression cassette allowing expression of a functional LRIT3 protein in mammal eyes; said expression cassette is inserted in an expression vector, preferably an adeno-associated virus (AAV); accordingly, the present invention further relates to a recombinant adeno-associated virus (AAV) vector carrying a nucleic acid sequence encoding a normal LRIT3 gene, or fragment thereof, under the control of regulatory sequences which express the product of the gene in the ocular cells, a pharmaceutically acceptable composition comprising such a recombinant AAV vector and to its use for the treatment of congenital stationary night blindness
-
公开(公告)号：US20230381224A1
公开(公告)日：2023-11-30
申请号：US18338314
申请日：2023-06-20
IPC分类号： A61K35/00 , C07K14/235 , A61K9/00 , A61K35/74 , A61K39/02
CPC分类号： A61K35/00 , C07K14/235 , A61K9/007 , A61K35/74 , A61K39/099 , A61K2039/10
摘要： A method of reducing or preventing the development of airway inflammation in a subject includes the step of infecting the respiratory tract of a subject an amount of a composition including a pharmaceutically acceptable carrier and live attenuated pertactin-deficient Bordetella bacteria sufficient to colonize the respiratory tract of the subject. The step of infecting the subject with the live attenuated pertactin-deficient Bordetella bacteria results in reduction or prevention of the development of airway inflammation in the subject.
-
公开(公告)号：US20230293586A1
公开(公告)日：2023-09-21
申请号：US18296623
申请日：2023-04-06
申请人： Assistance Publique - Hopitaux de Paris , Fondation Imagine - Institut des Maladies Génétiques , Université Paris Cité , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle ANDRÉ , Marina CAVAZZANA , Kuiying MA , John TCHEN , Tayebeh-Shabi SOHEILI , Ranjita Devi MOIRANGTHEM
IPC分类号： A61K35/17 , C12N5/0783
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/125 , C12N2501/145 , C12N2501/2307 , C12N2501/25 , C12N2501/26 , C12N2501/42 , C12N2506/11 , C12N2533/52
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
6.发明公开公开(公告)号：US20230212231A1
公开(公告)日：2023-07-06
申请号：US17927804
申请日：2021-05-26
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Baylor Research Institute , Assistance Publique - Hopitaux de Paris (APHP) , Universite Paris Est Creteil Val de Marne
发明人： Yves LEVY , Gérard ZURAWSKI , Sandra ZURAWSKI , Christine LACABARATZ , Sylvain CARDINAUD , Mathieu SURENAUD
IPC分类号： C07K14/005 , C07K16/28 , A61P31/14
CPC分类号： C07K14/005 , C07K16/2878 , C07K16/2851 , A61P31/14 , C12N2770/20022 , C07K2319/74 , C12N2770/20034 , A61K39/00
摘要： The present disclosure provides polypeptides derived from SARS-CoV-2 which have therapeutic use. One such polypeptide is a polypeptide, referred to as “Npep2,” is derived from the SARS-CoV-2 protein N and has at least 50 consecutive amino acids of the amino acid sequence having at least 90% identity with the amino acid sequence that ranges from the residue at position 276 to the residue at position 411 of SEQ ID NO:2. Further described are conjugates wherein a heterologous polypeptide is conjugated or fused to Npep2. The present disclosure further provides vaccines employing the polypeptides, polynucleotides encoding the polypeptides, and methods of vaccinating subjects against SARS-CoV-2 by administering a therapeutically effective amount of one or more of the polypeptides.
-
公开(公告)号：US11638723B2
公开(公告)日：2023-05-02
申请号：US17173632
申请日：2021-02-11
申请人： Assistance Publique—Hopitaux de Paris , Fondation Imagine—Institut des Maladies Génétiques , Université Paris Cité , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： Isabelle André , Marina Cavazzana , Kuiying Ma , John Tchen , Tayebeh-Shabi Soheili , Ranjita Devi Moirangthem
摘要： The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
-
公开(公告)号：US20220362369A1
公开(公告)日：2022-11-17
申请号：US17817272
申请日：2022-08-03
摘要： A Fim3-producing BPZE1 derivative with sufficiently stable fim3 expression to provide improved protection in mice against Fim3-only producing clinical B. pertussis isolates was developed. The fim3 expression in BPZE1f3 did not alter the protective efficacy against Fim2+ strains, nor against strains that produce neither Fim2 nor Fim3.
-
公开(公告)号：US20220213265A1
公开(公告)日：2022-07-07
申请号：US17609155
申请日：2020-05-06
申请人： Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université de Strasbourg
摘要： The present invention concerns a polymer comprising repetitive units having the following formula (I) wherein R1 is H or Me; L is a linker; R2 is the side chain of an α-amino acid being other than arginine; m is 0 or an integer comprised from 1 to 10; n is an integer comprised from 1 to 10; and X— is a counterion.
-
公开(公告)号：US20220195035A1
公开(公告)日：2022-06-23
申请号：US17687909
申请日：2022-03-07
申请人： Les Laboratoires Servier , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS)
IPC分类号： C07K16/26 , G01N33/574
摘要： The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.
-
-
-
-
-
-
-
-
-
搜索结果
130 条记录 (耗时 0.034 秒)
