公开(公告)号：US08852657B2

公开(公告)日：2014-10-07

申请号：US11971523

申请日：2008-01-09

Applicant: Ji-Fu Zhao ,  Julie Tseng-Crank ,  Mesfin Yimam ,  Qi Jia

Inventor： Ji-Fu Zhao ,  Julie Tseng-Crank ,  Mesfin Yimam ,  Qi Jia

IPC: A61K36/886 ,  A61K36/00 ,  A61K36/704 ,  A61K31/7048 ,  A61K31/35 ,  A61K31/352 ,  A61K36/48 ,  A61K36/38 ,  A61K36/489

CPC classification number: A61K31/352 ,  A61K31/35 ,  A61K31/7048 ,  A61K36/38 ,  A61K36/48 ,  A61K36/489 ,  A61K36/704 ,  A61K36/886

Abstract: The identification and isolation of chromones and novel chromone compositions from plant sources that exhibit up-regulation of adiponectin production by adipocytes and the normalization of virtually hundreds of genes related to glucose and fatty acid metabolic and signaling pathways. The chromone compositions are effective in enhancing adiponectin production by adipocytes and regulating genes involved in fatty acid biosynthesis, mitochondrial β-oxidation of fatty acids, steroid biosynthesis, gluconeogenesis, fat transport, PPARα/RXRα liver signaling and xenobiotic metabolism. The chromone compositions can be used to increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals. Included are methods for the prevention and treatment of a variety of diseases and conditions including, but not limited to insulin resistance, glucose intolerance, hyperglycemia, metabolic syndromes, dyslipidemia, and hypertriglyceridemia.

Abstract translation: 鉴定和分离来自植物来源的色酮和新的色酮组合物，其表现出脂肪细胞脂联素产生的上调，以及与葡萄糖和脂肪酸代谢和信号通路相关的几乎几百个基因的归一化。 色酮组合物可有效增强脂肪细胞的脂联素产生，调节脂肪酸生物合成，线粒体和脂肪酸的氧化，类固醇生物合成，糖异生，脂肪转运，PPARα/RXRα肝脏信号转导和异种生物代谢等因素的调控。 色酮组合物可用于增加胰岛素敏感性，改善葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物中的葡萄糖水平。 包括预防和治疗各种疾病和病症的方法，包括但不限于胰岛素抵抗，葡萄糖不耐受，高血糖症，代谢综合征，血脂异常和高甘油三酯血症。

公开(公告)号：US08592488B2

公开(公告)日：2013-11-26

申请号：US12814190

申请日：2010-06-11

Applicant: Qi Jia ,  Ji-Fu Zhao

Inventor： Qi Jia ,  Ji-Fu Zhao

IPC: A61K31/75

CPC classification number: A61K8/347 ,  A61K8/31 ,  A61K8/4973 ,  A61K8/97 ,  A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/357 ,  A61K31/40 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/02 ,  C07C39/15 ,  C07C39/367 ,  C07C41/26 ,  C07C41/32 ,  C07C43/23 ,  C07C45/673 ,  C07C49/835 ,  C07C215/74 ,  C07D321/12 ,  Y02A50/406 ,  Y02A50/411

Abstract: Diarylalkanes having the following structure: wherein Ar1, Ar2, R6, R7 and n are as defined herein are provided. The disclosed compounds find utility as inhibitors of binuclear enzymes. Methods for inhibiting binuclear enzymes as well as methods and compositions for preventing and treating diseases and conditions associated with binuclear enzymes are also provided.

Abstract translation: 具有以下结构的二芳基烷烃：其中Ar1，Ar2，R6，R7和n如本文所定义。 所公开的化合物可用作双核酶的抑制剂。 还提供了抑制双核酶的方法以及用于预防和治疗与双核酶相关的疾病和病症的方法和组合物。

公开(公告)号：US20080166438A1

公开(公告)日：2008-07-10

申请号：US11971523

申请日：2008-01-09

Applicant: Ji-Fu Zhao ,  Julie Tseng-Crank ,  Mesfin Yimam ,  Qi Jia

Inventor： Ji-Fu Zhao ,  Julie Tseng-Crank ,  Mesfin Yimam ,  Qi Jia

IPC: A61K31/352 ,  A61K31/7048 ,  A61P3/00 ,  A61K36/886

CPC classification number: A61K31/352 ,  A61K31/35 ,  A61K31/7048 ,  A61K36/38 ,  A61K36/48 ,  A61K36/489 ,  A61K36/704 ,  A61K36/886

Abstract: The present invention describes the identification and isolation of chromones and novel chromone compositions from plant sources that exhibit up-regulation of adiponectin production by adipocytes and the normalization of virtually hundreds of genes related to glucose and fatty acid metabolic and signaling pathways. The chromone compositions are effective in enhancing adiponectin production by adipocytes and regulating genes involved in fatty acid biosynthesis, mitochondrial β-oxidation of fatty acids, steroid biosynthesis, gluconeogenesis, fat transport, PPARα/RXRα liver signaling and xenobiotic metabolism. The chromone compositions can be used to increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals. Included in the present invention are methods for the prevention and treatment of a variety of diseases and conditions including, but not limited to insulin resistance, glucose intolerance, hyperglycemia, metabolic syndromes, dyslipidemia, and hypertriglyceridemia.

Abstract translation: 本发明描述了鉴定和分离来自植物来源的色酮和新的色酮组合物，其显示脂肪细胞脂联素产生的上调和几乎几百个与葡萄糖和脂肪酸代谢和信号通路相关基因的标准化。 色酮组合物有效促进脂肪细胞的脂联素产生，调节脂肪酸生物合成，脂肪酸线粒体β-氧化，类固醇生物合成，糖异生，脂肪转运，PPARalpha / RXRalpha肝信号转导和异种生物代谢的基因。 色酮组合物可用于增加胰岛素敏感性，改善葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物中的葡萄糖水平。 本发明包括预防和治疗各种疾病和病症的方法，包括但不限于胰岛素抵抗，葡萄糖不耐受，高血糖症，代谢综合症，血脂异常和高甘油三酯血症。

公开(公告)号：US20050239904A1

公开(公告)日：2005-10-27

申请号：US11157992

申请日：2005-06-21

Applicant: Qi Jia ,  Ji-Fu Zhao

Inventor： Qi Jia ,  Ji-Fu Zhao

IPC: A61K31/045 ,  A61K35/63 ,  A61K35/64

CPC classification number: A61K31/045 ,  A61K35/63 ,  Y10S514/925 ,  A61K2300/00

Abstract: The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as “polycosanol” produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.

Abstract translation: 本发明提供了一种新颖的方法，用于制备具有24至30个碳原子的伯脂肪醇，其特征在于由昆虫螨属分泌的蜡。 本发明中包括由本发明的方法生产的物质组合物，这里称为“多可醇”。 多糖醇组合物主要由四种脂族醇，二十四烷醇，二十四烷醇，三十烷醇组成。 本发明还包括所述物质组合物用于预防和治疗肥胖症，综合征X，糖尿病，高胆固醇血症，动脉粥样硬化并发症，局部缺血和血栓形成的用途。