公开(公告)号：US4842566A

公开(公告)日：1989-06-27

申请号：US58043

申请日：1987-06-04

申请人： Keisuke Nagao

发明人： Keisuke Nagao

IPC分类号： A63H3/40

CPC分类号： A63H3/40 ,  Y10T403/7039

摘要： An eye device for a doll or the like which comes to the eye-closed state by placing the doll in a lying posture and then comes to the eye-open state by placing the doll in a standing or sitting posture. This device is firmly held onto the doll face to such a degree that even if the eye member is strongly pressed from the front side, there is no apprehension of the eye member detaching from its holding position on the doll face. To this end the eye device includes at least one circular engaging step portion on the periphery of an eyeball-mounting body and, optionally, at least one circular engaging groove and/or steps on an inner periphery of a mounting member whereby material of the doll face, sandwiched between the eyeball-mounting body and the mounting member, is engaged by the circular engaging step portion on the eyeball-mounting body and, optionally, also by the circular engaging groove and/or steps on the mounting member, thereby preventing detaching of the eye device.

摘要翻译： 一种娃娃等的眼睛装置，其通过将娃娃置于躺姿态而进入眼睛关闭状态，然后通过将娃娃置于站姿或坐姿来进入眼睛打开状态。 该装置被牢固地保持在玩偶面上，使得即使眼部构件从前侧被强力按压，眼睛构件也不会从娃娃脸上的保持位置脱离。 为此，眼睛装置包括在眼球安装体的周边上的至少一个圆形接合台阶部分，以及可选地，至少一个圆形接合槽和/或安装构件的内周上的台阶，从而使玩偶的材料 夹在眼球安装体和安装构件之间的面由眼球安装体上的圆形接合台阶部分和可选地由圆形接合槽和/或安装构件上的台阶接合，从而防止分离 的眼睛装置。

公开(公告)号：US08350118B2

公开(公告)日：2013-01-08

申请号：US12736800

申请日：2009-05-15

申请人： Masayuki Amagai ,  Akiharu Kubo ,  Keisuke Nagao

发明人： Masayuki Amagai ,  Akiharu Kubo ,  Keisuke Nagao

IPC分类号： A01K67/027 ,  C12N5/00

CPC分类号： A01K67/0276 ,  A01K2217/00 ,  A01K2267/035

摘要： The object of the present invention is to provide a mouse model for allergic diseases such as atopic dermatitis, and a dermatitis mouse model with impaired skin-barrier function. The present inventors found out that a mouse that has been caused to completely lose the function of expressing profilaggrin protein and filaggrin protein by entirely or partially disrupting the endogenous gene encoding filaggrin by a genetic mutation such as deletion or replacement, can be used as a mouse model for allergic diseases or atopic dermatitis wherein the skin-barrier function has been impaired.

摘要翻译： 本发明的目的是提供一种用于过敏性疾病例如特应性皮炎的小鼠模型和具有受损的皮肤屏障功能的皮炎小鼠模型。 本发明人发现，通过完全或部分地破坏编码丝聚蛋白的内源基因，通过遗传突变（例如缺失或替换）完全失去表达丝胶蛋白和丝聚蛋白的功能的小鼠可以用作小鼠 过敏性疾病或特应性皮炎的模型，其中皮肤屏障功能受损。

公开(公告)号：US20110088103A1

公开(公告)日：2011-04-14

申请号：US12736800

申请日：2009-05-15

申请人： Masayuki Amagai ,  Akiharu Kubo ,  Keisuke Nagao

发明人： Masayuki Amagai ,  Akiharu Kubo ,  Keisuke Nagao

IPC分类号： A01K67/00

CPC分类号： A01K67/0276 ,  A01K2217/00 ,  A01K2267/035

摘要： The object of the present invention is to provide a mouse model for allergic diseases such as atopic dermatitis, and a dermatitis mouse model with impaired skin-barrier function. The present inventors found out that a mouse that has been caused to completely lose the function of expressing profilaggrin protein and filaggrin protein by entirely or partially disrupting the endogenous gene encoding filaggrin by a genetic mutation such as deletion or replacement, can be used as a mouse model for allergic diseases or atopic dermatitis wherein the skin-barrier function has been impaired.

摘要翻译： 本发明的目的是提供一种用于过敏性疾病如特应性皮炎的小鼠模型和具有受损的皮肤屏障功能的皮炎小鼠模型。 本发明人发现，通过完全或部分地破坏编码丝聚蛋白的内源基因，通过遗传突变（例如缺失或替换）完全失去表达丝胶蛋白和丝聚蛋白的功能的小鼠可以用作小鼠 过敏性疾病或特应性皮炎的模型，其中皮肤屏障功能受损。

公开(公告)号：US07150640B2

公开(公告)日：2006-12-19

申请号：US11398753

申请日：2006-04-06

申请人： Masayuki Fukui ,  Keisuke Nagao ,  Teruo Yokota

发明人： Masayuki Fukui ,  Keisuke Nagao ,  Teruo Yokota

IPC分类号： H01R13/62

CPC分类号： H01R13/62955 ,  H01R13/62938

摘要： The present invention is to provide a lever type connector to assure unlocking of a lever locking portion at a small size connector. The lever type connector has a cover having electric wire holder ribs at a rear surface of the cover. The electric wire holder ribs are disposed at a base portion of the lever locking portion and protrude downwardly from the rear surface of the cover so as to abut the electric wires. The electric wire holder ribs extend laterally to the electric wires and have a enough height to prevent the electric wires from interfering with a clearance, which allows the lever locking portion to move into the clearance. The clearance assured by the electric wire holder ribs ensures unlocking of the lever locking portion even when the electric wires occupy a large space in the connector.

摘要翻译： 本发明提供一种杠杆式连接器，以确保在小尺寸连接器处解锁锁定部分。 杠杆式连接器具有在盖的后表面上具有电线保持器肋的盖。 电线保持器肋设置在杠杆锁定部的基部并从盖的后表面向下突出以抵靠电线。 电线保持器肋横向延伸到电线并且具有足够的高度以防止电线干扰间隙，这允许杠杆锁定部分移动到间隙中。 通过电线保持器肋保证的间隙即使当电线在连接器中占据大的空间时也确保了锁定锁定部的解锁。

公开(公告)号：US20060228921A1

公开(公告)日：2006-10-12

申请号：US11398753

申请日：2006-04-06

申请人： Masayuki Fukui ,  Keisuke Nagao ,  Teruo Yokota

发明人： Masayuki Fukui ,  Keisuke Nagao ,  Teruo Yokota

IPC分类号： H01R13/62

CPC分类号： H01R13/62955 ,  H01R13/62938

摘要： The present invention is to provide a lever type connector to assure unlocking of a lever locking portion at a small size connector. The lever type connector has a cover having electric wire holder ribs at a rear surface of the cover. The electric wire holder ribs are disposed at a base portion of the lever locking portion and protrude downwardly from the rear surface of the cover so as to abut the electric wires. The electric wire holder ribs extend laterally to the electric wires and have a enough height to prevent the electric wires from interfering with a clearance, which allows the lever locking portion to move into the clearance. The clearance assured by the electric wire holder ribs ensures unlocking of the lever locking portion even when the electric wires occupy a large space in the connector.

摘要翻译： 本发明提供一种杠杆式连接器，以确保在小尺寸连接器处解锁锁定部分。 杠杆式连接器具有在盖的后表面上具有电线保持器肋的盖。 电线保持器肋设置在杠杆锁定部的基部并从盖的后表面向下突出以抵靠电线。 电线保持器肋横向延伸到电线并且具有足够的高度以防止电线干扰间隙，这允许杠杆锁定部分移动到间隙中。 通过电线保持器肋保证的间隙即使当电线在连接器中占据大的空间时也确保了锁定锁定部的解锁。