公开(公告)号：US20120179237A1

公开(公告)日：2012-07-12

申请号：US13005090

申请日：2011-01-12

Applicant: Keith R. Milner ,  Matthew S. Huser

Inventor： Keith R. Milner ,  Matthew S. Huser

IPC: A61F2/82 ,  B05B5/025 ,  B05C5/00 ,  B05D1/02 ,  B05D3/00

CPC classification number: B29C41/003 ,  B05B13/0214 ,  B05B13/0442 ,  B29C41/085 ,  B29C41/365 ,  B29C41/52 ,  B29L2031/7532 ,  B29L2031/755

Abstract: A spray system and method of using such spray system to fabricate a polymer membrane structure for use as a vascular graft or tissue engineered scaffold is provided. Generally, this spray system includes the use of at least two spray apparatus to apply different polymer and solvent mixtures to the outer surface of a mandrel to form a blended layer. Upon curing of the blended layer, phase separation occurs leading to the formation of a polymer membrane structure having variable properties along at least a portion of its longitudinal axis.

Abstract translation: 提供了一种使用这种喷雾系统制造用作血管移植物或组织工程支架的聚合物膜结构的喷雾系统和方法。 通常，该喷雾系统包括使用至少两个喷雾装置以将不同的聚合物和溶剂混合物施加到心轴的外表面以形成混合层。 在混合层固化后，发生相分离，导致在其纵轴的至少一部分上形成具有可变性质的聚合物膜结构。