公开(公告)号：US20150119434A1

公开(公告)日：2015-04-30

申请号：US14524738

申请日：2014-10-27

Applicant: LEO Laboratories Limited

Inventor： Johan Selmer ,  Kim Mark Knudsen

IPC: A61K31/4155

CPC classification number: A61K31/422 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/41 ,  A61K31/4155

Abstract: The invention relates to the topical treatment of actinic keratosis with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).

Abstract translation: 本发明涉及用异头烯醇3-（3,5-二乙基异恶唑-4-羧酸酯）局部治疗光化性角化病。

公开(公告)号：US20150119433A1

公开(公告)日：2015-04-30

申请号：US14524731

申请日：2014-10-27

Applicant: LEO Laboratories Limited

Inventor： Johan Selmer ,  Kim Mark Knudsen

IPC: A61K31/422

CPC classification number: A61K31/422 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/41 ,  A61K31/4155

Abstract: The invention relates to the topical treatment of actinic keratosis on the full balding scalp with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).

Abstract translation: 本发明涉及用美沙芬3-（3,5-二乙基异恶唑-4-羧酸酯）的全秃头皮上局部治疗光化性角化病。

公开(公告)号：US20140348905A1

公开(公告)日：2014-11-27

申请号：US14364561

申请日：2012-12-12

Applicant: LEO LABORATORIES LIMITED

Inventor： Per Ola Arvidsson ,  Edit Farkas ,  Karsten Petersson ,  Gert Hoy

IPC: A61K31/22 ,  A61K9/00 ,  A61K47/12 ,  A61K9/06 ,  A61K47/10 ,  A61K47/38

CPC classification number: A61K31/22 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/122 ,  A61K31/215 ,  A61K31/222 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44

Abstract: The present invention relates to a topical gel composition comprising ingenol-3-angelate, wherein the composition provides greater flux, according to the in vitro diffusion test, of ingenol-3-angelate into the stratum corneum, epidermis and dermis after application of the gel composition to skin than does a reference gel of ingenol-3-angelate, namely the PICATO® product.

Abstract translation: 本发明涉及含有美尼芬醇-3-天竺葵素的局部凝胶组合物，其中根据体外扩散试验，组合物在施用凝胶后在角质层，表皮和真皮中提供更大的通量 组合物与皮肤比参考凝胶的美沙酮-3-天竺葵，即PICATO®产品。

公开(公告)号：US20140322310A1

公开(公告)日：2014-10-30

申请号：US14364562

申请日：2012-12-12

Applicant: LEO LABORATORIES LIMITED

Inventor： Per Ola Arvidsson ,  Edit Farkas ,  Karsten Petersson ,  Gert Hoy

IPC: A61K9/06 ,  A61K31/215

CPC classification number: A61K31/22 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/122 ,  A61K31/215 ,  A61K31/222 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44

Abstract: Topical gel compositions comprising ingenol-3-angelate, wherein less than 10% of the ingenol-3-angelate degrades when the gel is stored for 2 years at 25° C.

Abstract translation: 包含西蒙酚-3-当归酸的局部凝胶组合物，其中当凝胶在25℃下储存2年时，小于10％的内酯-3-当归降解。

公开(公告)号：US20130225678A1

公开(公告)日：2013-08-29

申请号：US13769811

申请日：2013-02-18

Applicant: Leo Laboratories Limited

Inventor： Marc Barry Brown ,  Michael Crothers ,  Tahir Nazir

IPC: A61K31/215

CPC classification number: A61K31/22 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/215 ,  A61K36/47 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38

Abstract: Ingenol angelate is a potent anticancer agent, and can be stabilised by dissolving it in an aprotic solvent in the presence of an acidic buffer.

公开(公告)号：US20130225677A1

公开(公告)日：2013-08-29

申请号：US13769809

申请日：2013-02-18

Applicant: Leo Laboratories Limited

Inventor： Marc Barry Brown ,  Michael Crothers ,  Tahir Nazir

IPC: A61K31/215

CPC classification number: A61K31/22 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/215 ,  A61K36/47 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38

Abstract: Ingenol angelate is a potent anticancer agent, and can be stabilised by dissolving it in an aprotic solvent in the presence of an acidic buffer.

公开(公告)号：US20130158110A1

公开(公告)日：2013-06-20

申请号：US13769821

申请日：2013-02-18

Applicant: Leo Laboratories Limited

Inventor： Marc Barry Brown ,  Michael Crothers ,  Tahir Nazir

IPC: A61K31/22

CPC classification number: A61K31/22 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/215 ,  A61K36/47 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38

Abstract: Ingenol angelate is a potent anticancer agent, and can be stabilised by dissolving it in an aprotic solvent in the presence of an acidic buffer.

公开(公告)号：US09833429B2

公开(公告)日：2017-12-05

申请号：US15163295

申请日：2016-05-24

Applicant: LEO Laboratories Limited

Inventor： Marc Barry Brown ,  Michael Edward Donald Crothers ,  Tahir Nazir

IPC: A61K31/25 ,  A61P35/00 ,  A61K31/22 ,  A61K9/00 ,  A61K9/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K31/215 ,  A61K47/38 ,  A61K36/47

CPC classification number: A61K31/22 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/215 ,  A61K36/47 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38

Abstract: Ingenol angelate is a potent anticancer agent, and can be stabilized by dissolving it in an aprotic solvent in the presence of an acidic buffer.

公开(公告)号：US20170258756A1

公开(公告)日：2017-09-14

申请号：US15529607

申请日：2015-11-27

Applicant: LEO Laboratories Limited

Inventor： Casper Clemmensen ,  Johan Selmer ,  Kim Mark Knudsen

IPC: A61K31/235 ,  C07D521/00 ,  A61K31/4025 ,  C07D273/01 ,  A61K31/55 ,  A61K31/41

CPC classification number: A61K31/235 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/55 ,  C07D273/01 ,  C07D521/00

Abstract: The invention relates to the treatment of actinic keratosis on the scalp with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).

公开(公告)号：US09713608B2

公开(公告)日：2017-07-25

申请号：US14524875

申请日：2014-10-27

Applicant: LEO Laboratories Limited

Inventor： Johan Selmer ,  Kim Mark Knudsen

IPC: A61K31/422 ,  A61K9/06 ,  A61K9/00 ,  A61K31/4155 ,  A61K31/41

CPC classification number: A61K31/422 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/41 ,  A61K31/4155

Abstract: The invention relates to the treatment of actinic keratosis on the trunk (except chest) or Extremities with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).