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21 条记录 (耗时 0.017 秒)

    System for the controlled release of active ingredients
    12.
    发明申请
    System for the controlled release of active ingredients 审中-公开
    用于控释活性成分的系统

    公开(公告)号：US20050163845A1

    公开(公告)日：2005-07-28

    申请号：US10507345

    申请日：2003-03-12

    申请人： Ubaldo Conte ,  Lauretta Maggi

    发明人： Ubaldo Conte ,  Lauretta Maggi

    IPC分类号： A61K9/24 ,  A61K9/20 ,  A61K9/22 ,  A61K9/28

    CPC分类号： A61K9/2072 ,  A61K9/2886

    摘要： A new release system is disclosed for releasing one or more active substances vehicularised in it, at a predetermined rate and duration. The system is constituted by a pharmaceutical tablet, coated with a film of polymeric material impermeable and insoluble in aqueous fluids; on the coating film, one or more apertures of geometrically precise size and shape are made, through the use of a laser beam of appropriate power and intensity, in a way such that the active ingredient contained in the therapeutic system is released only from the non coated portion of the tablet surface at the desired rate and time. The technology for manufacturing such system is also described.

    摘要翻译： 公开了一种新的释放系统，用于以预定的速率和持续时间释放车辆中的一种或多种活性物质。 该系统由药片形成，涂覆有不透水且不溶于水性流体的聚合物材料膜; 在涂膜上，通过使用适当功率和强度的激光束，以使得治疗系统中包含的活性成分仅从非离子表面释放的方式制造具有几何精确尺寸和形状的一个或多个孔 片剂表面的涂覆部分以所需的速率和时间。 还描述了用于制造这种系统的技术。

    Pharmaceutical tablet capable of liberating one or more drugs at different release rates
    14.
    发明授权
    Pharmaceutical tablet capable of liberating one or more drugs at different release rates 失效
    能够以不同释放速度释放一种或多种药物的药片

    公开(公告)号：US06183778B2

    公开(公告)日：2001-02-06

    申请号：US09009672

    申请日：1998-01-20

    申请人： Ubaldo Conte ,  Aldo LaManna ,  Lauretta Maggi

    发明人： Ubaldo Conte ,  Aldo LaManna ,  Lauretta Maggi

    IPC分类号： A61K924

    CPC分类号： A61K9/209 ,  A61K9/2072 ,  A61K9/2086

    摘要： Pharmaceutical tablet consisting of a first layer containing one or more drugs with immediate or controlled release formulation, a second layer containing one or more drugs, either equal to or different from the first layer, with slow release formulation, and a low-permeability barrier-type layer coating said second layer or, alternatively, placed between the first and second layer and, if necessary, containing a drug.

    摘要翻译： 包含含有一种或多种立即或控释制剂的第一层，含有一种或多种药物的第二层，等同于或不同于第一层的缓释制剂的药片，以及低渗透阻隔剂， 类型层涂覆所述第二层，或者替代地，置于第一层和第二层之间，并且如果需要，包含药物。

    Pharmaceutical tablet capable of liberating one or more drugs at different release rates
    16.
    发明授权
    Pharmaceutical tablet capable of liberating one or more drugs at different release rates 失效
    能够以不同释放速度释放一种或多种药物的药片

    公开(公告)号：US5738874A

    公开(公告)日：1998-04-14

    申请号：US406873

    申请日：1995-03-24

    申请人： Ubaldo Conte ,  Aldo La Manna ,  Lauretta Maggi

    发明人： Ubaldo Conte ,  Aldo La Manna ,  Lauretta Maggi

    IPC分类号： A61K9/20 ,  A61K9/24 ,  A61K9/22 ,  A61K9/34 ,  A61K9/36

    CPC分类号： A61K9/2072 ,  A61K9/2086 ,  A61K9/209

    摘要： Pharmaceutical tablet consisting of a first layer containing one or more drugs with immediate or controlled release formulation, a second layer containing one or more drugs, either equal to or different from the first layer, with slow release formulation, and a low-permeability barrier-type layer coating said second layer or, alternatively, placed between the first and second layer and, if necessary, containing a drug.

    摘要翻译： PCT No.PCT / EP93 / 02556 Sec。 371日期：1995年3月24日 102（e）1995年3月24日PCT PCT 1993年9月21日PCT公布。 第WO94 / 06416号公报 日期：1994年3月31日由含有一种或多种立即或控释制剂的第一层组成的药物片剂，含有一种或多种药物的第二层，等同于或不同于第一层，缓释制剂，以及 低渗透性屏障型层涂覆所述第二层，或者替代地，置于第一层和第二层之间，并且如果需要，包含药物。

    Process for preparing pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times
    17.
    发明授权
    Process for preparing pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times 失效
    制备能随时释放其中所含活性成分的药片的方法

    公开(公告)号：US5487901A

    公开(公告)日：1996-01-30

    申请号：US248338

    申请日：1994-05-24

    申请人： Ubaldo Conte ,  Aldo La Manna ,  Lauretta Maggi

    发明人： Ubaldo Conte ,  Aldo La Manna ,  Lauretta Maggi

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/24 ,  A61K47/38

    CPC分类号： A61K9/209 ,  A61K9/2072

    摘要： A pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times produced via the steps of: a) preparing a tablet consisting of three superposed layers, the upper layer containing an active ingredient, the intermediate layer not containing any active ingredient and forming a barrier-type layer, and the lower layer containing an active ingredient, said upper layer presenting a raised top, b) coating the tablet entirely with an impermeable polymeric film, and c) removing said raised top and thus allowing contact of the abraded upper layer surface with the environment.

    摘要翻译： 一种能够随后通过以下步骤释放其中包含的活性成分的药片：a）制备由三个重叠层组成的片剂，上层含有活性成分，中间层不含有活性成分，并形成 阻挡层，下层含有活性成分，所述上层具有凸起的顶部，b）用不可渗透的聚合物膜全部涂覆所述片剂，以及c）除去所述凸起顶部，从而允许磨损的上层 表面与环境。

    LOW-FRIABILITY, PATIENT-FRIENDLY ORALLY DISINTEGRATING FORMULATIONS
    18.
    发明申请
    LOW-FRIABILITY, PATIENT-FRIENDLY ORALLY DISINTEGRATING FORMULATIONS 审中-公开
    低适应性，患者友好的ORALLY DISINC制剂

    公开(公告)号：US20070196494A1

    公开(公告)日：2007-08-23

    申请号：US11670293

    申请日：2007-02-01

    申请人： Arnaud Grenier ,  Celine Decaudin ,  Dario Norberto Carrara ,  Ubaldo Conte ,  Lauretta Maggi

    发明人： Arnaud Grenier ,  Celine Decaudin ,  Dario Norberto Carrara ,  Ubaldo Conte ,  Lauretta Maggi

    IPC分类号： A61K31/78

    CPC分类号： A61K9/0056 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2095 ,  A61K31/78

    摘要： The present invention relates to a rapidly disintegrating orally administratable solid dosage formulation that includes at least one active ingredient, at least one first disintegration agent that is at least one type-C methacrylic acid copolymer according to the U.S. Pharmacopoeia National Formulary US/NF, a second disintegration agent of crospovidone or a cross-linked povidone polymer derivative thereof, and a non-cariogenic diluent that does not increase glucose blood levels. The at least one first disintegration agent does not function as an enteric coating, insulation coating intended to protect active ingredient(s), or coating intended to mask taste or smell. The solid dosage form has a mass of about 50 to about 1000 mg, and the at least one first disintegration agent is present in the dosage form in an amount not exceeding 15%, with respect to the total weight of the dosage form. The second disintegration agent is present in the dosage form in an amount not exceeding 15% with respect to the total weight of the dosage form. The first and the second disintegration agent are present in total amounts that provide a weight ratio of about 1:1 to about 1:3, wherein the dosage form provides at least one of the in vitro or in vivo disintegration time that is less than 30 seconds, and has a friability of 1% or less according to the U.S. Pharmacopoeia test.

    摘要翻译： 本发明涉及快速崩解的可口服给药的固体剂型制剂，其包含至少一种活性成分，至少一种第一崩解剂，其是根据US Pharmacopoeia National Formulary US / NF至少一种C型甲基丙烯酸共聚物， 交联聚维酮的第二崩解剂或其交联聚维酮聚合物衍生物和不增加葡萄糖血液水平的非致龋剂稀释剂。 至少一种第一崩解剂不用作肠溶衣，旨在保护活性成分的绝缘涂层或旨在掩蔽味道或气味的涂层。 相对于剂型的总重量，固体剂型具有约50至约1000mg的质量，并且至少一种第一崩解剂以不超过15％的量存在于剂型中。 相对于剂型的总重量，第二崩解剂以不超过15％的量存在于剂型中。 第一和第二崩解剂以提供重量比为约1:1至约1:3的总量存在，其中该剂型提供至少一种体外或体内崩解时间小于30 秒，根据美国药典测试，其脆度为1％以下。

    Pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times
    19.
    发明授权
    Pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times 失效
    能够随后释放其中所含活性成分的药片

    公开(公告)号：US5650169A

    公开(公告)日：1997-07-22

    申请号：US547246

    申请日：1995-10-24

    申请人： Ubaldo Conte ,  Aldo La Manna ,  Lauretta Maggi

    发明人： Ubaldo Conte ,  Aldo La Manna ,  Lauretta Maggi

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/24 ,  A61K47/38

    CPC分类号： A61K9/209 ,  A61K9/2072

    摘要： A pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times produced via the steps of: a) preparing a tablet consisting of three superposed layers, the upper layer containing an active ingredient, the intermediate layer not containing any active ingredient and forming a barrier-type layer, and the lower layer containing an active ingredient, said upper layer presenting a raised top, b) coating the tablet entirely with an impermeable polymeric film, and c) removing said raised top and thus allowing contact of the abraded upper layer surface with the environment.

    摘要翻译： 一种能够随后通过以下步骤释放其中包含的活性成分的药片：a）制备由三个重叠层组成的片剂，上层含有活性成分，中间层不含有活性成分，并形成 阻挡层，下层含有活性成分，所述上层具有凸起的顶部，b）用不可渗透的聚合物膜全部涂覆所述片剂，以及c）除去所述凸起顶部，从而允许磨损的上层 表面与环境。

    Controlled release pharmaceutical tablet having lenticular form
    20.
    发明授权
    Controlled release pharmaceutical tablet having lenticular form 失效
    具有透镜形式的控释药片

    公开(公告)号：US5626874A

    公开(公告)日：1997-05-06

    申请号：US352072

    申请日：1994-11-30

    申请人： Ubaldo Conte ,  Aldo La Manna ,  Lauretta Maggi

    发明人： Ubaldo Conte ,  Aldo La Manna ,  Lauretta Maggi

    IPC分类号： A61K9/20 ,  A61K9/22

    CPC分类号： A61K9/2086

    摘要： Controlled release pharmaceutical tablet having a lenticular form consisting of three layers of which the central one or core (a) contains the active principle and the two outer layers or barriers (b) and (c) comprise gellable and/or erodible polymeric material, said barrier layers being equal or different among themselves for composition and/or thickness, while the central layer has a limited external annular surface exposed to the dissolution medium, through which the active principle is released.

    摘要翻译： 具有由三层组成的透镜形式的控释药物片剂，其中中心体或核心（a）含有活性成分，两个外层或屏障（b）和（c）包含可凝胶化和/或可侵蚀的聚合材料，所述 阻挡层在其组成和/或厚度之间相同或不同，而中心层具有暴露于溶解介质的有限的外部环形表面，通过该阻挡层释放活性原理。