公开(公告)号：US20100110287A1

公开(公告)日：2010-05-06

申请号：US12262639

申请日：2008-10-31

Applicant: Yu LIU ,  Ka Man CHENG ,  Yan HUO ,  Lu WANG

Inventor： Yu LIU ,  Ka Man CHENG ,  Yan HUO ,  Lu WANG

IPC: H04N7/00

CPC classification number: H04N5/262 ,  G06T5/002 ,  G06T2207/10016 ,  G06T2207/10024 ,  G06T2207/20204

Abstract: This invention relates to a method and system for modeling film grain noise. The film grain noise as modeled is applied to a video signal. Both the signal-dependent aspect 430 and the correlation aspect 440 of the film grain noise are taken into consideration, resulting in a more realistic modeling of film grain noise. Furthermore, the efficiency and the flexibility for modeling film grain noise are improved by use of the method and system according to this invention.

Abstract translation: 本发明涉及一种用于建模胶片颗粒噪声的方法和系统。 模拟的胶片颗粒噪声被应用于视频信号。 考虑到胶片颗粒噪声的信号相关方面430和相关方面440，导致对胶片颗粒噪声的更逼真的建模。 此外，通过使用根据本发明的方法和系统，提高了胶片颗粒噪声建模的效率和灵活性。

公开(公告)号：US20090123450A1

公开(公告)日：2009-05-14

申请号：US12179121

申请日：2008-07-24

Applicant: Ning Man Cheng ,  Yun Chung Leung ,  Wai Hung Lo

Inventor： Ning Man Cheng ,  Yun Chung Leung ,  Wai Hung Lo

IPC: A61K38/50 ,  A61P35/00

CPC classification number: C12N9/78 ,  A61K38/00 ,  C12N9/14

Abstract: The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion in a patient. The present invention also provides a pharmaceutical composition comprising the modified invention enzyme and method for treatment of diseases using the pharmaceutical composition.

Abstract translation: 本发明提供了具有足够高的酶活性和稳定性的分离和基本纯化的重组人精氨酸酶，以维持患者中足够的精氨酸消耗。 本发明还提供了包含该修饰的发明酶的药物组合物和使用该药物组合物治疗疾病的方法。

公开(公告)号：US20090068166A1

公开(公告)日：2009-03-12

申请号：US12282647

申请日：2007-03-15

Applicant: Ning Man Cheng

Inventor： Ning Man Cheng

IPC: A61K38/46 ,  C12N9/14 ,  A61P35/04 ,  A61P43/00

CPC classification number: A61K38/50

Abstract: Methods are described for using an arginine depleting agent such as arginase and derivatives thereof, which reduce physiological arginine levels, as radioprotectants to protect normal mammalian cells from DNA damage caused by ionizing radiation. Treatment can result in the protection of normal tissues in cancer patients undergoing radiotherapy and in protection from the hazardous effects of exposure to radiological dispersal devices or occupational and environmental ionizing radiation.

Abstract translation: 描述了使用精氨酸消耗剂如精氨酸酶及其衍生物降低生理精氨酸水平的方法作为保护正常哺乳动物细胞免受由电离辐射引起的DNA损伤的放射防护剂。 治疗可以保护正在进行放射治疗的癌症患者的正常组织，并防止暴露于放射性分散装置或职业和环境电离辐射的危险作用。

公开(公告)号：US20080292609A1

公开(公告)日：2008-11-27

申请号：US11751050

申请日：2007-05-21

Applicant: Ning Man Cheng ,  Yun Chung Leung ,  Wai Hung Lo

Inventor： Ning Man Cheng ,  Yun Chung Leung ,  Wai Hung Lo

IPC: A61K38/46 ,  A61P35/00

CPC classification number: A61K38/50 ,  A61K38/51 ,  A61K2300/00

Abstract: The present invention provides a method for treating cancer in a human patient by reducing the physiological arginine levels to below 10 μM in combination with administering an anti-neoplastic compound. The present invention also provides a pharmaceutical composition comprising an arginine reducing compound, such as pegylated human arginase I, and an anti-neoplastic compound, such as 5-fluorouracil, for the treatment of malignancies in a human patient.

Abstract translation: 本发明提供了一种通过将生理精氨酸水平降低至10μM以下并与施用抗肿瘤化合物组合来治疗人类患者的癌症的方法。 本发明还提供了一种药物组合物，其包含精氨酸还原化合物，例如聚乙二醇化人精氨酸酶I和抗肿瘤化合物如5-氟尿嘧啶，用于治疗人类患者的恶性肿瘤。

公开(公告)号：USD402066S

公开(公告)日：1998-12-01

申请号：US069052

申请日：1997-03-20

Applicant: Sai-Man Cheng

Designer： Sai-Man Cheng

公开(公告)号：US08387819B2

公开(公告)日：2013-03-05

申请号：US12854178

申请日：2010-08-11

Applicant: Ashleigh Ka Ying Chu ,  Nga Man Cheng ,  Chung Man Shum

Inventor： Ashleigh Ka Ying Chu ,  Nga Man Cheng ,  Chung Man Shum

IPC: B65D6/18

CPC classification number: B65D85/72 ,  B65D1/0292 ,  Y10S215/90

Abstract: A carbonated beverage container includes a bottle having a flexible sidewall of generally circular cross section, a cap for closing a top opening of the bottle, pairs of coupling elements provided on diametrically opposite portions of the sidewall respectively and configured to be pushed towards each other and couple together, thereby partially collapsing the bottle and expelling a predetermined amount of air therefrom. A method of preserving the taste of carbonated beverage in a container is also disclosed.

公开(公告)号：US20120258500A1

公开(公告)日：2012-10-11

申请号：US13370604

申请日：2012-02-10

Applicant: Man Cheng

Inventor： Man Cheng

IPC: C12P19/34 ,  C12N9/12

CPC classification number: C12N9/12 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/41 ,  C07K2319/42 ,  C07K2319/80 ,  C12N9/1247 ,  C12N9/1252 ,  C12N9/127 ,  C12N9/1276 ,  C12Q1/6848 ,  C12Q1/686 ,  C12Q2521/101 ,  C12Q2522/101 ,  C12Q2527/119 ,  C12Q2527/125 ,  C12Q2527/137

Abstract: The present invention provides methods for improving the specificity of nucleic acid amplification comprising incubating a nucleic acid molecule with a polymerase-Sso7 DNA binding domain conjugate and arginine, spermidine, or spermine. The present invention also provides reaction mixtures and kits for improving the specificity of nucleic acid amplification.

Abstract translation: 本发明提供了改善核酸扩增特异性的方法，包括用核酸分子与聚合酶-Sso7 DNA结合结构域缀合物和精氨酸，亚精胺或精胺孵育。 本发明还提供了用于提高核酸扩增特异性的反应混合物和试剂盒。

公开(公告)号：US20110104760A1

公开(公告)日：2011-05-05

申请号：US12683950

申请日：2010-01-07

Applicant: Xiao-Song Gong ,  John Sullivan ,  Rongdian Fu ,  Yan Wang ,  Evan H. Bursey ,  Man Cheng

Inventor： Xiao-Song Gong ,  John Sullivan ,  Rongdian Fu ,  Yan Wang ,  Evan H. Bursey ,  Man Cheng

IPC: C12P19/34 ,  C12N9/96 ,  C12N9/12 ,  C07K16/00 ,  C07H21/04

CPC classification number: C12P19/34 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2319/80 ,  C12N9/1252 ,  C12Q1/6804 ,  C12Q1/686 ,  C12Q2531/113 ,  C12Q2527/125 ,  C12Q2521/101

Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonuclease activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.

Abstract translation: 本发明提供了提高核酸扩增反应效率的方法和组合物。 本发明包括显示比野生型聚合酶增加的活性以及降低的外切核酸酶活性的杂合聚合酶。 本发明还包括用于进行核酸合成和扩增反应的方法，组合物和试剂盒，其中引物的非特异性扩增减少。

公开(公告)号：US20100136559A1

公开(公告)日：2010-06-03

申请号：US12618076

申请日：2009-11-13

Applicant: Steve Okino ,  Man Cheng

Inventor： Steve Okino ,  Man Cheng

IPC: C12Q1/68

CPC classification number: C12Q1/68 ,  C12Q2527/125

Abstract: The present application provides methods and compositions for determining accessibility of a DNA modifying agent in genomic DNA.

Abstract translation: 本申请提供了用于确定DNA修饰剂在基因组DNA中的可及性的方法和组合物。

公开(公告)号：US20080086534A1

公开(公告)日：2008-04-10

申请号：US11973201

申请日：2007-10-05

Applicant: Ulas Bardak ,  Betty Yee Man Cheng ,  Jahanzeb Ahmed Sherwani ,  Vasco Calais Pedro

Inventor： Ulas Bardak ,  Betty Yee Man Cheng ,  Jahanzeb Ahmed Sherwani ,  Vasco Calais Pedro

IPC: G06F15/16

CPC classification number: G07F17/3255 ,  G06Q30/02 ,  G07F17/32 ,  G07F17/3295 ,  H04L51/046

Abstract: A system and method for obtaining personal data about registered users using gaming principles is described. A data storage component receives and stores one or more items of personal data for each registered user. Multiple messages authored by multiple registered users are generated and displayed to a user interface for each registered user. The user interface provides a means for one registered user to select and categorize a message authored by another registered user. Based upon the nature of this categorized response, the responding user or seeker either gains or loses an item of personal data about author-user. Competition among users at different levels is introduced by applying a sorting process that limits the messages displayed to a particular user. In addition, resource management tools can be applied to limit author-user messages and seeker-user responses. Further, user actions and messages are scored and rankings are provided to all users. A communications link, allowing direct communication among users, can be provided when one user is awarded a sufficient amount of personal information about another user.

Abstract translation: 描述使用游戏原理来获取关于注册用户的个人数据的系统和方法。 数据存储组件接收并存储每个注册用户的一个或多个个人数据项。 生成由多个注册用户创作的多个消息，并将其显示给每个注册用户的用户界面。 用户界面提供了一个注册用户选择和分类由另一个注册用户编写的消息的手段。 根据这种分类响应的性质，回复的用户或者搜索者获取或丢失关于作者用户的个人数据项。 通过应用限制向特定用户显示的消息的排序过程来引入不同级别的用户之间的竞争。 此外，可以应用资源管理工具来限制作者用户消息和寻找者用户响应。 此外，用户操作和消息得分并且向所有用户提供排名。 当一个用户被授予足够数量的关于另一个用户的个人信息时，可以提供允许用户之间直接通信的通信链路。