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22 条记录 (耗时 0.023 秒)

    Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods
    16.
    发明授权
    Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods 有权
    用于估计分析物相关信号的方法，包括用于控制方法性能的编程的微处理器以及采用该方法的分析物监测装置

    公开(公告)号：US07699775B2

    公开(公告)日：2010-04-20

    申请号：US10963853

    申请日：2004-10-13

    申请人： Shashi P. Desai ,  Timothy C. Dunn ,  Matthew J. Lesho ,  Russell O. Potts ,  Janet A. Tamada ,  Charles W. Wei

    发明人： Shashi P. Desai ,  Timothy C. Dunn ,  Matthew J. Lesho ,  Russell O. Potts ,  Janet A. Tamada ,  Charles W. Wei

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/1477 ,  A61N1/30

    摘要： The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.

    摘要翻译： 本发明涉及增加用于提供分析物测量值的分析物相关信号的数量的方法，例如当使用两个或更多个与分析物相关的信号来获得单个分析物测量值时，基于两个分析物相关信号的“滚动”值 或更多的信号。 在另一方面，内插和/或外插方法用于估计不可用，缺失或与误差相关的分析物相关信号。 此外，在本发明的另一方面，采用了内插和外推值来减少校准失败的事件。 此外，本发明涉及采用梯度和/或预测算法来提供与超过预定阈值的分析物值相关的警报的方法。 本发明包括上述方法，被编程为执行方法的一个或多个微处理器，被编程为执行方法和控制至少一个感测和/或采样装置的一个或多个微处理器，以及采用本文描述的方法的监视系统。

    Micropressors, devices and methods for use in analyte monitoring systems
    17.
    发明授权
    Micropressors, devices and methods for use in analyte monitoring systems 有权
    用于分析物监测系统的微压机，装置和方法

    公开(公告)号：US07523004B2

    公开(公告)日：2009-04-21

    申请号：US11270857

    申请日：2005-11-09

    申请人： Miroslaw Bartkowiak ,  Wesley S. Harper ,  Eray Kulcu ,  Matthew J. Lesho ,  Janet A. Tamada

    发明人： Miroslaw Bartkowiak ,  Wesley S. Harper ,  Eray Kulcu ,  Matthew J. Lesho ,  Janet A. Tamada

    IPC分类号： G06F19/00

    CPC分类号： A61B5/681 ,  A61B5/0531 ,  A61B5/14532 ,  A61B5/7242 ,  G01N27/3271 ,  Y10T436/144444

    摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.

    摘要翻译： 本发明包括一个或多个微处理器，其被编程为执行用于通过利用预测的较慢时间常数（1 / k2）来改善受试者的葡萄糖水平的预测来提高分析物监测装置的性能的方法。 在本发明的另一方面，预指数项（1 / c2）可以用于提供信号衰减的校正（例如增益因子）。 在其他方面，本发明涉及一种或多种微处理器，其包括编程以控制（i）用于条件筛选数据点以减少跳过的测量的方法的执行，（ii）用于限定插值/外推分析物测量值的方法，（iii） 获得分析物相关信号的最大积分的各种集成方法，以及包括这种微处理器的分析物监测装置。 此外，本发明涉及用于改进需要优化可调参数的预测模型中使用的参数优化的算法。

    Method and device for time-effective biomolecule detection
    20.
    发明申请
    Method and device for time-effective biomolecule detection 审中-公开
    用于时间有效的生物分子检测的方法和装置

    公开(公告)号：US20080124716A1

    公开(公告)日：2008-05-29

    申请号：US11605353

    申请日：2006-11-29

    申请人： Christopher G. Cooney ,  Matthew J. Lesho

    发明人： Christopher G. Cooney ,  Matthew J. Lesho

    IPC分类号： C12Q1/68 ,  C12M1/00

    CPC分类号： C12Q1/6813

    摘要： Rapid detection of biomolecules in samples involving biochemical amplification of the target biomolecule is achieved by collecting or separating aliquots of the amplification reaction mixture prior to completion of amplification and assaying these samples as they are collected.

    摘要翻译： 通过在扩增反应混合物的等分试样收集或分离之前，通过收集或分离这些样品进行分析，可以快速检测涉及靶生物分子生物化学扩增的样品中的生物分子。