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11.发明授权Compositions and methods for modifying and modulating the activity of central nervous system depressants 失效用于修饰和调节中枢神经系统抑制剂活性的组合物和方法
公开(公告)号：US3382147A
公开(公告)日：1968-05-07
申请号：US17915762
申请日：1962-03-12
发明人： PROCTOR CHARLES D
IPC分类号： A61K31/66
CPC分类号： A61K31/66 , A61K31/54 , A61K31/515 , A61K2300/00
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公开(公告)号：US20230068887A1
公开(公告)日：2023-03-02
申请号：US17948184
申请日：2022-09-19
摘要： Pharmaceutical compositions and methods of treatment or prevention of diseases and conditions associated with or characterized by at least one of xerostomia and periodontal disease by modulation of the nitric oxide synthase pathway are provided, as are animal models and drug screening methods. Such modulation may be achieved by the administration of tetrahydrobiopterin (BH4) or its prodrugs and/or salts. Treating and preventing xerostomia can have the downstream effect of also preventing periodontitis, dental caries, parotid gland enlargement, inflammation and fissuring of the lips (chelitis), inflammation or ulcers of the tongue and buccal mucosa, oral candidiasis, salivary gland infection (sialadenitis), halitosis, and cracking and fissuring of oral mucosa.
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公开(公告)号：US20220372544A1
公开(公告)日：2022-11-24
申请号：US17872674
申请日：2022-07-25
发明人： Amosy M'KOMA
IPC分类号： C12Q1/37 , C12Q1/6837 , C12Q1/6876 , G01N33/58 , G01N33/60 , G01N33/68 , C12Q1/6883
摘要： Methods and materials are disclosed for testing biomarkers in a subject suffering from inflammatory bowel disease (IBD) are described herein. Such detection can be useful for diagnosing and treating ulcerative colitis (UC) and Crohn's disease (CD), two forms of IBD that are otherwise difficult to distinguish. The method includes measuring the level of one or more of several biomarkers, including HD5 or MMP-7, which are expressed differentially in patents with UC and CD. A treatment may be based on the determination of whether the subject has ulcerative colitis or Crohn's disease.
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公开(公告)号：US11504414B2
公开(公告)日：2022-11-22
申请号：US16363908
申请日：2019-03-25
发明人： Hua Xie , Richard J. Lamont
摘要： Peptides related to certain portions of the arginine deiminase enzyme from the bacterium Streptococcus cristatus are provided that disrupt the formation and composition of biofilms containing the oral pathogen Porphyromonas gingivalis, and also modulate the virulence of P. gingivalis. Pharmaceutical compositions containing such peptides and method of using the same are disclosed.
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15.发明申请公开(公告)号：US20210278417A1
公开(公告)日：2021-09-09
申请号：US16622259
申请日：2018-06-20
发明人： Amosy E. M'Koma , Amos M. Sakwe
IPC分类号： G01N33/68 , C12Q1/6883
摘要： A targeted DEFA5 antibody is disclosed herein. The targeted DEFA5 antibody has a high degree of specificity with DEFA5 protein, particularly with peptide sequences of the P, B, and/or M binding sites of the DEFA5 protein. The targeted DEFA5 antibody may be incorporated into an assay for diagnosing and treating ulcerative colitis and Crohns disease in a subject suffering from inflammatory bowel disease. The assay may be provided in a kit. The targeted DEFA5 antibody may be used in a method for measuring the level of DEFA5 or DEFA5 expression in a sample collected from a subject, and determining, based on the level of DEFA5 or DEFA5 expression, whether the subject is suffering from ulcerative colitis or Crohns disease. A treatment may be based on the determination of whether the subject has ulcerative colitis or Crohns disease.
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公开(公告)号：US20210228664A1
公开(公告)日：2021-07-29
申请号：US17207677
申请日：2021-03-21
发明人： Anthony E. Archibong , Bindong Liu , G. William Bates , Elochukwu J. Ezekakpu , Lorin W. Simon , James E.K. Hildreth
IPC分类号： A61K36/185 , A61K45/06 , A61K9/00 , A01N1/02 , A61B17/43
摘要： Artificial cervical fluid is disclosed that contains a mucilaginous extract from the okra plant. The mucilaginous extract can be produced using a hot aqueous extractant or cold extraction process followed by separation of larger particles from the extract. The extract finds many uses, for example as a sperm storage medium, a sperm freezing medium, a sexual lubricant, an artificial insemination medium, an in vitro fertilization medium, and methods for treating and/or preventing infection, replication, and transmission of viruses, such as sexually transmitted viruses.
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公开(公告)号：US20200276201A1
公开(公告)日：2020-09-03
申请号：US16876181
申请日：2020-05-18
摘要： Pharmaceutical compositions and methods of treatment or prevention of diseases and conditions associated with or characterized by at least one of xerostomia and periodontal disease by modulation of the nitric oxide synthase pathway are provided, as are animal models and drug screening methods. Such modulation may be achieved by the administration of tetrahydrobiopterin (BH4) or its prodrugs and/or salts. Treating and preventing xerostomia can have the downstream effect of also preventing periodontitis, dental caries, parotid gland enlargement, inflammation and fissuring of the lips (chelitis), inflammation or ulcers of the tongue and buccal mucosa, oral candidiasis, salivary gland infection (sialadenitis), halitosis, and cracking and fissuring of oral mucosa.
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公开(公告)号：US20200149087A1
公开(公告)日：2020-05-14
申请号：US16571034
申请日：2019-09-13
发明人： Amosy M'KOMA
IPC分类号： C12Q1/37 , C12Q1/6876 , C12Q1/6837 , G01N33/60 , G01N33/58 , G01N33/68 , A61K45/06
摘要： Methods and materials are disclosed for testing biomarkers in a subject suffering from inflammatory bowel disease (IBD) are described herein. Such detection can be useful for diagnosing and treating ulcerative colitis (UC) and Crohn's disease (CD), two forms of IBD that are otherwise difficult to distinguish. The method includes measuring the level of one or more of several biomarkers, including HD5 or MMP-7, which are expressed differentially in patents with UC and CD. A treatment may be based on the determination of whether the subject has ulcerative colitis or Crohn's disease.
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公开(公告)号：US20190309298A1
公开(公告)日：2019-10-10
申请号：US16436696
申请日：2019-06-10
发明人： Donald J. ALCENDOR , Waldemar POPIK
IPC分类号： C12N15/113 , A61P31/14
摘要： An antiviral agent is provided, having a phosphorodiamidate morpholino oligomer with an antisense sequence to a portion of a genome of a strain of Zika virus (ZIKV). The antiviral agent finds many uses, such as in a pharmaceutical composition, a method of treating ZIKV-mediated disease, a method of preventing ZIKV-mediated disease, a method of reducing or preventing the replication of ZIKV in a host cell, a method of controlling the spread of ZIKV in donated tissue, a treated tissue sample, and in the manufacture of a medicament for the treatment or prevention or ZIKV-mediated disease.
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公开(公告)号：US11427852B2
公开(公告)日：2022-08-30
申请号：US16571034
申请日：2019-09-13
发明人： Amosy M'Koma
IPC分类号： C12Q1/6837 , C12Q1/6876 , G01N33/58 , G01N33/60 , G01N33/68 , C12Q1/6883 , A61K45/06 , C12Q1/37
摘要： Methods and materials are disclosed for testing biomarkers in a subject suffering from inflammatory bowel disease (IBD) are described herein. Such detection can be useful for diagnosing and treating ulcerative colitis (UC) and Crohn's disease (CD), two forms of IBD that are otherwise difficult to distinguish. The method includes measuring the level of one or more of several biomarkers, including HD5 or MMP-7, which are expressed differentially in patents with UC and CD. A treatment may be based on the determination of whether the subject has ulcerative colitis or Crohn's disease.
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