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公开(公告)号：US20220193166A1
公开(公告)日：2022-06-23
申请号：US17563350
申请日：2021-12-28
发明人： Anthony E. ARCHIBONG , G. William BATES , Elochukwu J. Ezekakpu , Lorin W. SIMON , James E.K. Hildreth
摘要： Artificial cervical fluid is disclosed that contains a mucilaginous extract from the okra plant. The mucilaginous extract can be produced using a hot aqueous extractant or cold extraction process followed by separation of larger particles from the extract. The extract finds many uses, for example as a sperm storage medium, a sperm freezing medium, a sexual lubricant, an artificial insemination medium, and an in vitro fertilization medium.
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公开(公告)号：US20210379030A1
公开(公告)日：2021-12-09
申请号：US17402998
申请日：2021-08-16
发明人： Hua XIE , Chin-Ho CHEN
IPC分类号： A61K31/439 , A61K31/166 , A61P31/04 , C12Q1/18 , A61P1/02 , A61K31/4748 , A61K8/02 , A61K8/04 , A61K8/42 , A61K8/49 , A61Q11/00 , G01N33/50
摘要： The disclosure provides compounds that inhibit the invasion of host cells by intracellular parasites. These find use, for example, in treating and preventing periodontitis or a periodontitis-related condition or symptom.
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公开(公告)号：US11123333B2
公开(公告)日：2021-09-21
申请号：US16278126
申请日：2019-02-17
发明人： Hua Xie , Chin-Ho Chen
IPC分类号： A61K31/439 , A61K31/166 , A61P31/04 , C12Q1/18 , A61P1/02 , A61K31/4748 , A61K8/02 , A61K8/04 , A61K8/42 , A61K8/49 , A61Q11/00 , G01N33/50
摘要： The disclosure provides compounds that inhibit the invasion of host cells by intracellular parasites. These find use, for example, in treating and preventing periodontitis or a periodontitis-related condition or symptom.
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公开(公告)号：US11241466B2
公开(公告)日：2022-02-08
申请号：US16294839
申请日：2019-03-06
发明人： Anthony E. Archibong , G. William Bates , Elochukwu J. Ezekakpu , Lorin W. Simon , James E. K. Hildreth
摘要： Artificial cervical fluid is disclosed that contains a mucilaginous extract from the okra plant. The mucilaginous extract can be produced using a hot aqueous extractant or cold extraction process followed by separation of larger particles from the extract. The extract finds many uses, for example as a sperm storage medium, a sperm freezing medium, a sexual lubricant, an artificial insemination medium, and an in vitro fertilization medium.
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公开(公告)号：US20210123015A1
公开(公告)日：2021-04-29
申请号：US17031611
申请日：2020-09-24
发明人： Donald J. ALCENDOR
IPC分类号： C12N5/073
摘要： Methods for isolating a population of cells from tissue are disclosed herein. In particular, the present disclosure provides methods for isolating cytotrophoblasts from placental tissue. The methods include isolating a population of cells with the use of a laboratory apparatus that is coated with a lubricant, such as petroleum jelly. The methods described herein achieve consistent in vitro isolation of purified cells.
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公开(公告)号：US20200087619A1
公开(公告)日：2020-03-19
申请号：US16677542
申请日：2019-11-07
摘要： A method of enhancing sperm fertility is described herein. The method includes contacting sperm with hydroxyurea. A composition is disclosed that includes sperm, hydroxyurea, and a buffer. Methods, kits, and compositions for enhancing sperm fertility are also provided.
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公开(公告)号：US20220000904A1
公开(公告)日：2022-01-06
申请号：US17244272
申请日：2021-04-29
发明人： Donald J. ALCENDOR
IPC分类号： A61K31/7125 , A61K47/64 , A61P31/14
摘要： An antiviral agent is provided, having a phosphorodiamidate morpholino oligomer with an antisense sequence to a portion of a genome of a strain of a coronavirus. The coronavirus may be SARS-CoV-2 or another βCoV. The antiviral agent finds many uses, such as in a pharmaceutical composition, a method of treating coronavirus-mediated disease, a method of preventing coronavirus-mediated disease, a method of reducing or preventing the replication of coronavirus in a host cell, a method of controlling the spread of coronavirus in donated tissue, a treated tissue sample, and in the manufacture of a medicament for the treatment or prevention or coronavirus-mediated disease.
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公开(公告)号：US11174482B2
公开(公告)日：2021-11-16
申请号：US16436696
申请日：2019-06-10
发明人： Donald J. Alcendor , Waldemar Popik
IPC分类号： C12N15/113 , A61P31/14 , A61K47/59 , C07F9/6558
摘要： An antiviral agent is provided, having a phosphorodiamidate morpholino oligomer with an antisense sequence to a portion of a genome of a strain of Zika virus (ZIKV). The antiviral agent finds many uses, such as in a pharmaceutical composition, a method of treating ZIKV-mediated disease, a method of preventing ZIKV-mediated disease, a method of reducing or preventing the replication of ZIKV in a host cell, a method of controlling the spread of ZIKV in donated tissue, a treated tissue sample, and in the manufacture of a medicament for the treatment or prevention or ZIKV-mediated disease.
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公开(公告)号：US20190201464A1
公开(公告)日：2019-07-04
申请号：US16294839
申请日：2019-03-06
发明人： Anthony E. ARCHIBONG , G. William BATES , Elochukwu J. Ezekakpu , Lorin W. SIMON , James E.K. Hildreth
CPC分类号： A61K36/185 , A01N1/021 , A01N1/0221 , A61B17/43 , A61F6/04 , A61K9/0034 , A61K9/06 , A61K2236/33 , A61K2236/39 , A61K2236/53 , A61P15/08 , C12N5/061
摘要： Artificial cervical fluid is disclosed that contains a mucilaginous extract from the okra plant. The mucilaginous extract can be produced using a hot aqueous extractant or cold extraction process followed by separation of larger particles from the extract. The extract finds many uses, for example as a sperm storage medium, a sperm freezing medium, a sexual lubricant, an artificial insemination medium, and an in vitro fertilization medium.
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公开(公告)号：US20190175565A1
公开(公告)日：2019-06-13
申请号：US16278126
申请日：2019-02-17
发明人： Hua XIE , Chin-Ho CHEN
IPC分类号： A61K31/439 , A61K8/42 , A61K8/49 , A61Q11/00 , A61K8/04 , A61K8/02 , G01N33/50 , A61K31/166 , A61P31/04
摘要： The disclosure provides compounds that inhibit the invasion of host cells by intracellular parasites. These find use, for example, in treating and preventing periodontitis or a periodontitis-related condition or symptom.
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