公开(公告)号：US5914328A

公开(公告)日：1999-06-22

申请号：US485537

申请日：1995-06-07

Applicant: Nan-Horng Lin ,  Mark W. Holladay ,  Melwyn A. Abreo ,  David E. Gunn ,  Suzanne A. Lebold ,  Richard L. Elliott ,  Yun He

Inventor： Nan-Horng Lin ,  Mark W. Holladay ,  Melwyn A. Abreo ,  David E. Gunn ,  Suzanne A. Lebold ,  Richard L. Elliott ,  Yun He

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  A61K31/425 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R.sup.1, R.sup.2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibiting neurotransmitter release; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to activate or inhibit neurotransmitter release in mammals.

Abstract translation: 具有下式的新型杂环醚化合物：其中*，A，B，n，R 1，R 2和X具体定义，或其药学上可接受的盐或前药，其可用于选择性活化或抑制神经递质释放; 到这些化合物的治疗有效的药物组合物; 以及使用所述组合物来激活或抑制哺乳动物中的神经递质释放。

公开(公告)号：US5733912A

公开(公告)日：1998-03-31

申请号：US802978

申请日：1997-02-19

Applicant: James T. Wasicak ,  David S. Garvey ,  Mark W. Holladay ,  Nan-Horng Lin ,  Keith B. Ryther

Inventor： James T. Wasicak ,  David S. Garvey ,  Mark W. Holladay ,  Nan-Horng Lin ,  Keith B. Ryther

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/41 ,  A61K31/44 ,  A61K31/50 ,  C07D487/08

CPC classification number: C07D487/04

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula ##STR1## wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

Abstract translation: 7a-取代的具有式“IMAGE”的六氢-1H-吡咯嗪化合物，其中A是限定的杂环部分，这些化合物的药物组合物，以及所述组合物用于选择性地控制哺乳动物突触传递的用途。

公开(公告)号：US5559242A

公开(公告)日：1996-09-24

申请号：US591806

申请日：1996-01-25

Applicant: Nan-Horng Lin ,  Yun He ,  Steven J. Wittenberger

Inventor： Nan-Horng Lin ,  Yun He ,  Steven J. Wittenberger

IPC: C07D413/04 ,  C07D261/06

CPC classification number: C07D413/04

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated.

Abstract translation: 以高产率制备对映异构纯的3-甲基-5-（1-（C 1 -C 3 - 烷基）-2-吡咯烷基）异恶唑的新方法，其中保护的2-氧代 - 吡咯烷起始原料与合适的有机 阴离子，得到的β-酮肟中间体被环化和脱水。

公开(公告)号：US5424444A

公开(公告)日：1995-06-13

申请号：US234442

申请日：1994-04-28

Applicant: Nan-Horng Lin ,  Yun He ,  Richard L. Elliott ,  Mukund S. Chorghade ,  Thomas K. J. Esch ,  Dieter O. Beer ,  Christian C. Witzig ,  Thomas C. Herzig ,  Steven J. Wittenberger ,  William H. Bunnelle ,  Bikshandar A. Narayanan ,  Pulla R. Singam ,  Alla V. Rama Rao

Inventor： Nan-Horng Lin ,  Yun He ,  Richard L. Elliott ,  Mukund S. Chorghade ,  Thomas K. J. Esch ,  Dieter O. Beer ,  Christian C. Witzig ,  Thomas C. Herzig ,  Steven J. Wittenberger ,  William H. Bunnelle ,  Bikshandar A. Narayanan ,  Pulla R. Singam ,  Alla V. Rama Rao

IPC: C07D413/04 ,  C07D261/08

CPC classification number: C07D413/04

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

Abstract translation: 以高产率制备对映异构纯的3-甲基-5-（1-（C 1 -C 3 - 烷基）-2-吡咯烷基）异恶唑的新方法，其中将受保护的吡咯烷或2-氧代 - 吡咯烷起始原料与 合适的有机阴离子和所得的β-酮肟中间体被环化和脱水，以及可用于其制备的中间体。

公开(公告)号：US5278176A

公开(公告)日：1994-01-11

申请号：US933458

申请日：1992-08-21

Applicant: Nan-Horng Lin

Inventor： Nan-Horng Lin

IPC: C07D401/04 ,  A61K31/44

CPC classification number: C07D401/04

Abstract: Selective and potent nicotinic agonists of the formula: ##STR1## including pharmaceutically-acceptable salts or prodrugs thereof, useful in the treatment of dementias, attentional hyperactivity disorder, anxiety associated with cognitive impairment, or substance abuse withdrawal characterized by decreased cholinergic function.

Abstract translation: 选择性和有效的烟酸激动剂，其分子式包括其药学上可接受的盐或前药，其可用于治疗痴呆症，注意性多动症，与认知障碍相关的焦虑症或以胆碱能功能降低为特征的药物滥用戒断。

公开(公告)号：US5126275A

公开(公告)日：1992-06-30

申请号：US584907

申请日：1990-09-19

Applicant: Robert P. Hatch ,  Jurgen Kocher ,  Nan-Horng Lin ,  Scott Ruetten ,  Klaus Wehling

Inventor： Robert P. Hatch ,  Jurgen Kocher ,  Nan-Horng Lin ,  Scott Ruetten ,  Klaus Wehling

IPC: C07D417/04 ,  C12Q1/00 ,  G01N21/78 ,  G01N31/22 ,  G01N33/50 ,  G01N33/52

CPC classification number: C12Q1/008 ,  G01N33/52 ,  G01N33/521 ,  Y10S435/805

Abstract: General classes of 2-thiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

公开(公告)号：US09340558B2

公开(公告)日：2016-05-17

申请号：US14137374

申请日：2013-12-20

Applicant: Lindsay Burns Barbier ,  Hoau-Yan Wang ,  Nan-Horng Lin ,  Andrei Blasko

Inventor： Lindsay Burns Barbier ,  Hoau-Yan Wang ,  Nan-Horng Lin ,  Andrei Blasko

IPC: A61K31/505 ,  C07D513/10 ,  C07D471/10 ,  C07D498/10

CPC classification number: C07D498/10 ,  C07D471/10 ,  C07D513/10

Abstract: A compound or its pharmaceutically acceptable salt, optionally including both individual enantiomeric forms, a racemate, diastereomers and mixtures thereof, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula A, wherein the R group substituents, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, and Z are defined within.

Abstract translation: 公开了可以提供止痛和减轻炎症的化合物或其药学上可接受的盐，任选地包括单独的对映体形式，外消旋物，非对映异构体及其混合物。 考虑的化合物具有对应于式A的结构，其中R基团取代基d，e，f，k，n，m，D，E，F，K，G，P，Q，W和Z被定义 中。

公开(公告)号：US08614324B2

公开(公告)日：2013-12-24

申请号：US12719624

申请日：2010-03-08

Applicant: Lindsay Burns Barbier ,  Hoau-Yan Wang ,  Nan-Horng Lin ,  Andrei Blasko

Inventor： Lindsay Burns Barbier ,  Hoau-Yan Wang ,  Nan-Horng Lin ,  Andrei Blasko

IPC: C07D491/10

CPC classification number: A61K31/438 ,  A61K31/537 ,  A61K31/54 ,  C07D471/10 ,  C07D498/10

Abstract: A compound or its pharmaceutically acceptable salt, optionally including both individual enantiomeric forms, a racemate, diastereomers and mixtures thereof, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula A, wherein the R group substituents, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, and Z are defined within.

Abstract translation: 公开了可以提供止痛和减轻炎症的化合物或其药学上可接受的盐，任选地包括单独的对映体形式，外消旋物，非对映异构体及其混合物。 考虑的化合物具有对应于式A的结构，其中R基团取代基d，e，f，k，n，m，D，E，F，K，G，P，Q，W和Z被定义 中。

公开(公告)号：US20110105487A1

公开(公告)日：2011-05-05

申请号：US12610091

申请日：2009-10-30

Applicant: LINDSAY BURNS BARBIER ,  Hoau-Yan Wang ,  Nan-Horng Lin ,  Andrei Blasko

Inventor： LINDSAY BURNS BARBIER ,  Hoau-Yan Wang ,  Nan-Horng Lin ,  Andrei Blasko

IPC: A61K31/537 ,  C07D498/10 ,  A61K31/438 ,  C07D471/10 ,  A61K31/527 ,  A61P29/00

CPC classification number: C07D471/10 ,  C07D498/10

Abstract: A compound or its pharmaceutically acceptable salt, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula A, wherein the R group substituents, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, and Z are defined within.

Abstract translation: 公开了可以提供止痛和减轻炎症的化合物或其药学上可接受的盐，组合物和方法。 考虑的化合物具有对应于式A的结构，其中R基团取代基d，e，f，k，n，m，D，E，F，K，G，P，Q，W和Z被定义 中。

公开(公告)号：US20110105484A1

公开(公告)日：2011-05-05

申请号：US12609518

申请日：2009-10-30

Applicant: Lindsay Burns Barbier ,  Hoau-Yan Wang ,  Nan-Horng Lin ,  Andrei Blasko

Inventor： Lindsay Burns Barbier ,  Hoau-Yan Wang ,  Nan-Horng Lin ,  Andrei Blasko

IPC: A61K31/438 ,  C07D498/10 ,  C07D471/10 ,  C07D513/10 ,  A61K31/527 ,  A61K31/5386 ,  A61K31/547 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07D471/10 ,  C07D498/10

Abstract: A compound, its pharmaceutically acceptable salt, a composition containing the same and method of treatment that can provide analgesia and/or reduce inflammation are disclosed. A contemplated compound has a structure that corresponds to Formula A, wherein G, W, Q, Z, D, E, F, K, Y, d, e, f, k, n, m, and circle B and all R groups are defined within.