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公开(公告)号:US08399483B2
公开(公告)日:2013-03-19
申请号:US12809394
申请日:2008-12-17
申请人: Daniel Rees Allen , George Martin Buckley , Roland Bürli , John Richard Davenport , Natasha Kinsella , Christopher James Lock , Christopher Lowe , Stephen Robert Mack , William Ross Pitt , Andrew James Ratcliffe , Marianna Dilani Richard , Verity Margaret Sabin , Andrew Sharpe , Laura Jane Tait , Graham John Warrellow , Sophie Caroline Williams
发明人: Daniel Rees Allen , George Martin Buckley , Roland Bürli , John Richard Davenport , Natasha Kinsella , Christopher James Lock , Christopher Lowe , Stephen Robert Mack , William Ross Pitt , Andrew James Ratcliffe , Marianna Dilani Richard , Verity Margaret Sabin , Andrew Sharpe , Laura Jane Tait , Graham John Warrellow , Sophie Caroline Williams
IPC分类号: A61K31/47
CPC分类号: C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , C07D473/34 , C07D473/36
摘要: A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions, said substituted derivatives having the general formula
摘要翻译: 因此,作为PI3激酶的选择性抑制剂的一系列杂芳基取代的喹喔啉和喹啉衍生物在医学中是有益的,例如在治疗炎性,自身免疫,心血管,神经退行性,代谢性,肿瘤学,伤害性感受性或眼科疾病中,所述 具有通式的取代衍生物