公开(公告)号：US10738044B2

公开(公告)日：2020-08-11

申请号：US15745947

申请日：2016-07-21

申请人： PROXIMAGEN, LLC

发明人： Lee Patient

IPC分类号： A61K31/44 ,  C07D471/04 ,  A61P21/00 ,  A61P1/16 ,  A61P9/00 ,  A61P19/02 ,  A61P1/00 ,  A61P25/00

摘要： {4-[3-(Dimethylamino)propoxy]phenyl}methyl (4S)-4-(propan-2-yl)-3H,4H,5H,6H,7H-imidazo[4,5-c]pyridine-5-carboxylate, and pharmaceutically or veterinarily acceptable salts thereof.

公开(公告)号：US10590125B2

公开(公告)日：2020-03-17

申请号：US15215026

申请日：2016-07-20

申请人： PROXIMAGEN, LLC

发明人： Max Espensen ,  Lee Patient ,  David Evans ,  Edward Savory ,  Iain Simpson

IPC分类号： C07D471/04 ,  A61K31/40 ,  C07C53/18

摘要： The present invention relates to compounds which are inhibitors of SSAO activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases, immune disorders and the inhibition of tumor growth.

公开(公告)号：US20230110165A1

公开(公告)日：2023-04-13

申请号：US17962273

申请日：2022-10-07

申请人： Proximagen, LLC

发明人： Max Espensen ,  Lee Patient ,  David Evans ,  Edward Savory ,  Iain Simpson

IPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/501 ,  A61K31/506 ,  C07C53/18

摘要： Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.

公开(公告)号：US11512082B2

公开(公告)日：2022-11-29

申请号：US16784320

申请日：2020-02-07

申请人： PROXIMAGEN, LLC

发明人： Max Espensen ,  Lee Patient ,  David Evans ,  Edward Savory ,  Iain Simpson

IPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/501 ,  A61K31/506 ,  C07C53/18

摘要： Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.

公开(公告)号：US20220348577A1

公开(公告)日：2022-11-03

申请号：US17190266

申请日：2021-03-02

申请人： Proximagen, LLC

发明人： Giles Brown ,  Michael Higginbottom ,  Alison Stewart ,  Lee Patient ,  Allison Carley ,  Iain Simpson ,  Edward Daniel Savory ,  Kathryn Oliver ,  Andrew Graham Cole

IPC分类号： C07D471/08 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D401/14 ,  C07D401/12 ,  C07D471/04 ,  C07B59/00 ,  C07D401/04 ,  C07D413/12 ,  C07D417/12

摘要： The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

公开(公告)号：US10766897B2

公开(公告)日：2020-09-08

申请号：US16542792

申请日：2019-08-16

申请人： PROXIMAGEN, LLC

发明人： Max Espensen ,  Lee Patient ,  David Evans ,  Iain Simpson ,  Edward Savory

IPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/501 ,  A61K31/506 ,  C07C53/18

摘要： The compounds of formula (I) are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the claims.

公开(公告)号：US11369616B2

公开(公告)日：2022-06-28

申请号：US16127363

申请日：2018-09-11

申请人： Proximagen, LLC

发明人： Peter Richardson

IPC分类号： A61K39/00 ,  A61K31/551 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28 ,  A61P35/00

摘要： The invention relates to a combination of CXCR4 antagonist 6-{4-[1-(Propan-2-yl)piperidin-4-yl]-1, 4-diazepan-1-yl}-N-(pyridin-4-yl)pyridine-2-carboxamide and an immune checkpoint inhibitor, and the use of the same in the treatment of tumours and/or cancers.

公开(公告)号：US20210024518A1

公开(公告)日：2021-01-28

申请号：US16986010

申请日：2020-08-05

申请人： Proximagen, LLC

发明人： Lee Patient

IPC分类号： C07D471/04 ,  A61P21/00 ,  A61P1/16 ,  A61P9/00 ,  A61P19/02 ,  A61P1/00 ,  A61P25/00

摘要： {4-[3-(Dimethylamino)propoxy]phenyl}methyl (4S)-4-(propan-2-yl)-3H,4H,5H,6H,7H-imidazo[4,5-c]pyridine-5-carboxylate, and pharmaceutically or veterinarily acceptable salts thereof.

公开(公告)号：US20200347059A1

公开(公告)日：2020-11-05

申请号：US16933417

申请日：2020-07-20

申请人： PROXIMAGEN, LLC

发明人： Max ESPENSEN ,  Lee PATIENT ,  David EVANS ,  Iain SIMPSON ,  Edward SAVORY

IPC分类号： C07D471/04 ,  A61K31/40 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/501 ,  A61K31/506 ,  C07C53/18

摘要： A process for the preparation of a compound of formula (Ia) or a pharmaceutically acceptable salt, or N-oxide thereof that includes reacting a compound of formula (IIIa) or (Va) with a compound of formula (IX) to form the compound of formula (Ia)

公开(公告)号：US20200281937A1

公开(公告)日：2020-09-10

申请号：US16492305

申请日：2018-03-09

申请人： Proximagen, LLC

发明人： Peter RICHARDSON

IPC分类号： A61K31/551 ,  A61P35/00

摘要： The invention relates to the use of the CXCR4 antagonist 6-{4-[1-(Propan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl}-N-(pyridin-4-yl)pyridine-2-carboxamide or a pharmaceutically acceptable salt thereof in the treatment of cancers of the breast, bladder, colon, rectum and liver.