公开(公告)号：US20110223200A1

公开(公告)日：2011-09-15

申请号：US13055775

申请日：2009-07-24

Applicant: James Brown ,  Pascal Mettens ,  Dennis Murphy

Inventor： James Brown ,  Pascal Mettens ,  Dennis Murphy

IPC: A61K39/04 ,  C07K19/00 ,  C07H21/04 ,  A61P31/06 ,  A61P37/04

CPC classification number: A61K39/04 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  C07H21/04 ,  C07K14/35 ,  G01N2333/35 ,  G01N2800/12

Abstract: The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis

Abstract translation: 本发明涉及一种多肽，其包含：（i）Rv1753c蛋白序列; （ii）Rv1753c蛋白序列的变体; 或（iii）Rv1753c蛋白序列的免疫原性片段。 在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法

公开(公告)号：US20110206712A1

公开(公告)日：2011-08-25

申请号：US13055787

申请日：2009-07-24

Applicant: James Brown ,  Pascal Mettens ,  Dennis Murphy

Inventor： James Brown ,  Pascal Mettens ,  Dennis Murphy

IPC: A61K39/04 ,  C07K19/00 ,  C07H21/00 ,  A61P31/06 ,  A61P37/04

CPC classification number: A61K39/04 ,  A61K38/00 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  C07K14/35 ,  C12N9/88 ,  C12N9/90

Abstract: The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; or (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.

Abstract translation: 本发明涉及一种多肽，其包含：（i）Rv2386c蛋白质序列; （ii）Rv2386c蛋白序列的变体; 或（iii）Rv2386c蛋白序列的免疫原性片段。 在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法。

公开(公告)号：US20110117119A1

公开(公告)日：2011-05-19

申请号：US13055801

申请日：2009-07-24

Applicant: Pascal Mettens ,  James Brown ,  Dennis Murphy

Inventor： Pascal Mettens ,  James Brown ,  Dennis Murphy

IPC: A61K39/04 ,  A61P31/06

CPC classification number: A61K39/04 ,  A61K49/00 ,  C07K14/35

Abstract: The present invention is directed to a polypeptide which comprises: (i) an Rv3616c protein sequence; (ii) a variant of an Rv3616c protein sequence; or (iii) an immunogenic fragment of an Rv3616c protein sequence for use in the treatment or prevention of latent TB. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of latent tuberculosis.

Abstract translation: 本发明涉及一种多肽，其包含：（i）Rv3616c蛋白序列; （ii）Rv3616c蛋白序列的变体; 或（iii）用于治疗或预防潜伏性TB的Rv3616c蛋白序列的免疫原性片段。 在其它方面，本发明涉及相关的多核苷酸，融合蛋白和用于治疗或预防潜伏性结核病的方法。