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公开(公告)号：US20240358825A1
公开(公告)日：2024-10-31
申请号：US18406869
申请日：2024-01-08
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, Jr. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K39/39 , A61K39/00 , A61K39/002 , A61K39/012 , A61K39/02 , A61K39/108 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61P37/02
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61P37/02 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/30
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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2.发明公开公开(公告)号：US20240358821A1
公开(公告)日：2024-10-31
申请号：US18577550
申请日：2022-07-06
CPC分类号： A61K39/29 , A61K9/127 , A61K9/5123 , A61P31/14 , C12N7/00 , A61K2039/53 , A61K2039/55555 , C12N2770/24222 , C12N2770/24234
摘要： Described are compositions comprising a nucleoside-modified RNA molecules encoding a HCV p7 protein in combination with at least one additional HCV antigen, adjuvant, or a combination thereof, and their use for inducing an immune response against HCV.
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公开(公告)号：US20240350598A1
公开(公告)日：2024-10-24
申请号：US18650535
申请日：2024-04-30
申请人： AC Immune SA
IPC分类号： A61K39/00 , A61K9/127 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005
CPC分类号： A61K39/0007 , A61K9/127 , A61K39/0003 , A61K39/0005 , A61K39/05 , A61K39/08 , A61K39/245 , A61K39/39 , A61P25/28 , C07K14/005 , A61K2039/55516 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/575 , A61K2039/58 , A61K2039/627 , A61K2039/645 , A61K2039/70 , C07K2319/33 , C07K2319/55 , C12N2710/16232 , C12N2710/16234 , C12N2760/16033
摘要： A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.
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公开(公告)号：US20240335532A1
公开(公告)日：2024-10-10
申请号：US18700024
申请日：2022-10-11
发明人： Brian HORSBURGH , Mark David MOODY
IPC分类号： A61K39/39 , A61K39/00 , A61K39/215 , A61K47/69
CPC分类号： A61K39/39 , A61K39/215 , A61K47/6951 , A61K2039/55511 , A61K2039/55555
摘要： The present disclosure relates to nanoparticulate vaccine adjuvants, and to vaccine compositions which contain nanoparticulate vaccine adjuvants; to methods of preparing such adjuvants and compositions; and to methods of using such compositions and adjuvants for vaccination. The vaccine adjuvants disclosed herein are effective for enhancing the immune response to vaccination.
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5.发明公开公开(公告)号：US20240317833A1
公开(公告)日：2024-09-26
申请号：US18381081
申请日：2023-10-17
发明人： Frank Bedu-Addo , Joseph Dervan , Gregory Conn
IPC分类号： C07K14/725 , A61K39/00 , A61K45/06 , A61P35/00
CPC分类号： C07K14/7051 , A61K45/06 , A61P35/00 , A61K2039/55555 , A61K2039/55572 , A61K2039/70
摘要： Novel compositions of TCR Gamma Alternate Reading Frame Protein (TARP) peptides combined with cationic lipids such as the DOTAP and specifically R-DOTAP, induce high levels of TARP-specific polyfunctional cytolytic T-cells. Compositions and methods of use are provided. The compositions comprise N-terminal and C-terminal overlapping peptide sequence pairs duplicating the critical central antigenic region of TARP and encompassing the entire protein selected and designed to be effectively processed by antigen-presenting cells to prime cytotoxic T cells specific for TARP-derived T cell peptide antigens when delivered in combination with immunostimulatory nanoparticles composed of R-DOTAP cationic lipids.
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6.发明公开公开(公告)号：US20240317828A1
公开(公告)日：2024-09-26
申请号：US18381979
申请日：2023-10-19
发明人： Frank Bedu-Addo , Joseph Dervan , Gregory Conn
CPC分类号： C07K14/4727 , A61K38/00 , A61K2039/55555 , A61K2039/572 , A61K2039/585 , A61K2039/70
摘要： Provided herein are multiepitope peptides including at least one mucin 1 (MUC1) peptide, the multiepitope peptides have MHC affinity for at least one of HLA serotype and are recognized by a CD4+ T cell receptor and/or by a CD8+ T cell receptor. Also provided herein are compositions comprising the multiepitope peptides and a cationic lipid, including vaccine compositions. In various aspects, the cationic lipid is R-DOTAP. The invention also provides methods of use of the multiepitope peptides and of the compositions and vaccine compositions. The methods of use include methods of treating cancer and method of inducing a MUC-specific polyfunctional cytolytic T cell response in a subject.
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公开(公告)号：US20240301006A1
公开(公告)日：2024-09-12
申请号：US18269120
申请日：2021-12-21
IPC分类号： C07K14/005 , A61K9/127 , A61K39/00 , C12N15/86
CPC分类号： C07K14/005 , A61K9/127 , C12N15/86 , A61K39/00 , A61K2039/55555 , A61K2039/572 , A61K2039/575 , C12N2710/24122 , C12N2710/24133 , C12N2760/14122 , C12N2760/14133 , C12N2760/16122 , C12N2760/16133 , C12N2770/36143
摘要： Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an interferon effector.
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公开(公告)号：US20240299529A1
公开(公告)日：2024-09-12
申请号：US18018519
申请日：2021-08-04
发明人： Ly James LEE , Chi-Ling CHIANG , Yifan MA
IPC分类号： A61K39/215 , A61K39/00 , A61K47/69 , C07K14/005 , C07K16/28
CPC分类号： A61K39/215 , A61K47/6901 , C07K14/005 , C07K16/2803 , C07K16/2827 , C07K16/2863 , A61K2039/55555 , C07K2317/24 , C07K2317/77 , C07K2317/92 , C12N2770/20022 , C12N2770/20034
摘要： Described herein are compositions of extracellular vesicles, and methods and systems of producing the extracellular vesicles. Also described herein are methods of using the extracellular vesicles.
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公开(公告)号：US20240299525A1
公开(公告)日：2024-09-12
申请号：US18418127
申请日：2024-01-19
申请人： ModernaTX, Inc.
发明人： Giuseppe Ciaramella , Kapil Bahl , Amy Espeseth , Andrew J. Bett , Pedro Cejas , Lan Zhang , Christine Shaw
CPC分类号： A61K39/12 , A61K9/0019 , A61K2039/53 , A61K2039/55555
摘要： The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.
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公开(公告)号：US20240299513A1
公开(公告)日：2024-09-12
申请号：US18572241
申请日：2022-06-22
CPC分类号： A61K39/0008 , A61P3/10 , A61K2039/53 , A61K2039/55555
摘要： This disclosure describes a nucleic acid construct that contains sequences for an Endotope construct, a STAT1c, and miR142 target sites. In one example, disclosed is composition comprising an Endotope construct and a STAT1 construct including a nucleic acid sequence encoding a constitutively active STAT1 (e.g. STAT1c), wherein the Endotope and the STAT1 constructs each include miR142 target sites. In alternative examples, disclosed is a single construct that includes the Endotope construct and STAT1 construct along with miR142 target sites. The nucleic acid constructs can be packaged into polycationic molecules or liposome to create nanoparticles for efficient cell transfection.
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