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    Utilization of derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain
    11.
    发明授权
    Utilization of derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain 有权
    四氢吡啶衍生物（或4-羟基哌啶） - 丁基二醇在制备用于治疗疼痛的药物中的应用

    公开(公告)号：US06384055B1

    公开(公告)日：2002-05-07

    申请号：US09743085

    申请日：2001-02-13

    Applicant: Ramon Merce-Vidal ,  Jordi Frigola-Constansa

    Inventor： Ramon Merce-Vidal ,  Jordi Frigola-Constansa

    IPC: A61K31445

    CPC classification number: A61K31/454 ,  A61K31/4439

    Abstract: Derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols of formula (I), wherein R1, R2 and R3, which are similar or different, represent each of them hydrogen, halogen, alkyl C1-C4, trifluoromethyl, hydroxyl, alkoxyl, or two adjacent radicals can form a ring; A is a C atom and the dotted line represents an additional bond, or A is a C atom joined to a hydroxyl group and the dotted line represents absence of additional bond; Z1 is N or CR4; Z2 is N or CR5; Z4 is N or CR7; and R4, R5, R6 and R7, which different, represent hydrogen, halogen, alkyl C1-C4, aryl or substituted aryl, or two adjacent radicals can form part of another ring. These derivatives are useful for the treatment of acute pain, neuropathic pain or nociceptive pain in mammals, including human beings.

    Abstract translation: 式（I）的四氢吡啶（或4-羟基哌啶） - 丁基二醇的衍生物，其中相同或不同的R 1，R 2和R 3各自表示氢，卤素，C 1 -C 4烷基，三氟甲基，羟基，烷氧基或 两个相邻的基团可以形成环; A是C原子，虚线表示附加键，或A是连接到羟基的C原子，虚线表示不存在附加键; Z1是N或CR4; Z2为N或CR5; Z4是N或CR7; 和不同的代表氢，卤素，烷基C1-C4，芳基或取代的芳基或两个相邻基团的R4，R5，R6和R7可以形成另一个环的一部分。 这些衍生物可用于治疗哺乳动物（包括人类）的急性疼痛，神经性疼痛或伤害性疼痛。

    Indol-6yl sulfonamide derivatives, their preparation and their use as 5-HT-6 as modulators
    16.
    发明授权
    Indol-6yl sulfonamide derivatives, their preparation and their use as 5-HT-6 as modulators 失效
    吲哚-6-基磺酰胺衍生物，它们的制备及其作为5-HT-6作为调节剂的用途

    公开(公告)号：US07462640B2

    公开(公告)日：2008-12-09

    申请号：US10566101

    申请日：2004-07-29

    Applicant: Ramon Merce Vidal ,  Xavier Codony Soler ,  Alberto Dordal Zueras

    Inventor： Ramon Merce Vidal ,  Xavier Codony Soler ,  Alberto Dordal Zueras

    IPC: A01N43/38 ,  A61K31/405 ,  C07D209/04

    CPC classification number: C07D409/12 ,  C07D209/08 ,  C07D513/04

    Abstract: The present invention refers to new sulfonamide derivatives, of general formula (Ia, Ib, Ic) optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, at any mixing ratio or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the process for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.

    Abstract translation: 本发明涉及通式（Ia，Ib，Ic）的新型磺酰胺衍生物，其任选呈其立体异构体之一形式，优选对映异构体或非对映异构体，其外消旋体或其至少两种立体异构体的混合物的形式， 优选对映异构体或非对映体，以任何混合比例或其盐，优选相应的生理上可接受的盐或相应的溶剂合物; 其制备方法，作为人和/或兽医治疗剂中的药物的应用，以及含有它们的药物组合物。

    SUBSTITUTED INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 RECEPTOR MODULATORS
    17.
    发明申请
    SUBSTITUTED INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 RECEPTOR MODULATORS 审中-公开
    取代的吲哚化合物及其作为5-HT6受体调节剂的用途

    公开(公告)号：US20070213326A1

    公开(公告)日：2007-09-13

    申请号：US11679344

    申请日：2007-02-27

    Applicant: Ramon Merce Vidal

    Inventor： Ramon Merce Vidal

    IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4178 ,  A61K31/416 ,  A61K31/405

    CPC classification number: C07D209/16 ,  C07D409/12 ,  C07D513/04

    Abstract: The present invention relates to substituted indole compound of general formula I, a process for their preparation, medicaments comprising substituted indole compounds as well as the use of substituted indole compounds for the preparation of medicaments, which are suitable e.g. for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via 5-HT6 receptors.

    Abstract translation: 本发明涉及通式I的取代的吲哚化合物，其制备方法，包含取代的吲哚化合物的药物以及用于制备药物的取代的吲哚化合物的用途， 用于预防和/或治疗通过5-HT 6受体至少部分介导的病症或疾病。

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