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公开(公告)号：US20070167448A1
公开(公告)日：2007-07-19
申请号：US11707571
申请日：2007-02-16
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/4745 , A61K31/454 , A61K31/405 , C07D413/02 , C07D403/02
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
摘要翻译： 本发明涉及具有通式（I）的磺酰胺的新衍生物，以及它们的生理上可接受的盐，其制备方法，它们作为人和/或兽医治疗中的药物的用途，以及含有 他们。
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2.发明授权Thienylazolylalcoxyethanamines, their preparation and their application as medicaments 失效噻吩并噻唑基羟乙胺，它们的制备及其作为药物的应用公开(公告)号：US06410582B1
公开(公告)日：2002-06-25
申请号：US09673186
申请日：2000-10-12
IPC分类号： A61K3141
CPC分类号： A61K31/4155 , C07D409/04 , C07D409/06
摘要： The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.
摘要翻译： 其中R 1是氢原子，卤素原子或低级烷基的噻吩基唑烷基乙胺（I） R2，R3和R4独立地表示氢原子或低级烷基; 并且Az表示含有一至三个氮原子的五元氮杂环芳族基团N-甲基取代基。 它们在哺乳动物，包括人类中具有止痛活性。 化合物（I）可以通过例如羟基噻吩唑（IV）的衍生物与合适的N-（乙基）胺衍生物的反应来获得。 化合物（IV）是化合物（I）的合成中的有用的中间体。 化合物（I）在人和/或兽医学中有应用。
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公开(公告)号：US07129361B2
公开(公告)日：2006-10-31
申请号：US10779287
申请日：2004-02-13
IPC分类号： C07D257/06 , C07D403/04 , C07D249/08 , C07D233/02
CPC分类号： A61K31/4155 , C07D409/04 , C07D409/06
摘要： The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.
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公开(公告)号：US20060258653A1
公开(公告)日：2006-11-16
申请号：US11487745
申请日：2006-07-17
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/498 , A61K31/454 , A61K31/405 , C07D413/02 , C07D403/02
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
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5.发明申请Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence 审中-公开用于治疗尿失禁的芳基（或杂芳基）唑基甲醇衍生物公开(公告)号：US20050131049A1
公开(公告)日：2005-06-16
申请号：US11045708
申请日：2005-01-28
IPC分类号： C07D231/12 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4196 , A61P7/12 , A61P13/10 , C07D409/06 , A61K31/416 , C07D49/02
CPC分类号： A61K31/4196 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164
摘要： Derivatives of aryl(or heteroaryl)azolylcarbinoles of general formula (I), in which Ar represents a phenyl radical or a thienyl radical, optionally substituted, R1 represents a hydrogen atom or a lower alkyl group, R2 represents a dialkylaminoalkyl or azaheterocylclylalkyl and Het represents an azole unsubstituted or optionally substituted by one or two substituents, and their physiologically acceptable salts; are useful as drugs in human and/or veterinary therapeutics to treat urinary incontinence in mammals, including man.
摘要翻译： 其中Ar表示苯基或噻吩基，任意取代的R 1表示氢原子或低级烷基，R（R 1）表示通式（I）的芳基（或杂芳基）唑基偶氮的衍生物， 代表二烷基氨基烷基或氮杂环己基烯基烷基，Het表示未取代或任选被一个或两个取代基取代的唑类及其生理上可接受的盐; 可用作人类和/或兽医治疗药物以治疗哺乳动物（包括人）中的尿失禁。
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公开(公告)号：US20070021485A1
公开(公告)日：2007-01-25
申请号：US11187697
申请日：2005-07-22
IPC分类号： A61K31/415 , C07D231/02
CPC分类号： C07D231/12 , A61K31/415
摘要： The present application provides a method of treating a subject suffering from a form of urinary incontinence which comprises administering to the subject an amount of a compound having the structure: effective to treat the subject, wherein the compound is administered in a suitable form.
摘要翻译： 本申请提供了治疗患有尿失禁形式的受试者的方法，其包括向受试者施用一定量的具有以下有效结构的化合物：有效治疗受试者，其中所述化合物以适当形式给药。
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公开(公告)号：US07452881B2
公开(公告)日：2008-11-18
申请号：US11707571
申请日：2007-02-16
IPC分类号： A61K31/5375 , A61K31/404 , C07D413/02 , C07D209/04
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
摘要翻译： 本发明涉及具有通式（I）的磺酰胺的新衍生物，以及它们的生理上可接受的盐，其制备方法，它们作为人和/或兽医治疗中的药物的用途，以及含有 他们。
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公开(公告)号：US20050032791A1
公开(公告)日：2005-02-10
申请号：US10933951
申请日：2004-09-03
IPC分类号： A61K31/404 , A61K31/4045 , A61K31/429 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04 , A61K31/541 , A61K31/405
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
摘要翻译： 本发明涉及具有通式（I）的磺酰胺的新衍生物，以及它们的生理上可接受的盐，其制备方法，它们作为人和/或兽医治疗中的药物的用途，以及含有 他们。
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公开(公告)号：US07498328B2
公开(公告)日：2009-03-03
申请号：US11487745
申请日：2006-07-17
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/404 , C07D413/06 , C07D209/04
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
摘要翻译： 本发明涉及具有通式（I）的磺酰胺的新衍生物及其生理上可接受的盐，其制备方法，它们作为人和/或兽医治疗中的药物的用途以及含有 他们。
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公开(公告)号：US07105515B2
公开(公告)日：2006-09-12
申请号：US10293206
申请日：2002-11-13
IPC分类号： A61K31/5375 , A61K31/495 , A61K31/404 , C07D413/06 , C07D209/04
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
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