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公开(公告)号：US20130018050A1
公开(公告)日：2013-01-17
申请号：US13619792
申请日：2012-09-14
申请人： WILLIAM R. BAKER , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： WILLIAM R. BAKER , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： C07D471/04 , A61K31/437 , A61K31/536 , A61P29/00 , A61P11/02 , A61P37/08 , A61P11/00 , A61P11/08 , A61P11/06 , A61P11/10 , A61K31/4709 , A61P31/00
CPC分类号： C07D471/04
摘要： This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.
摘要翻译： 本发明提供下式的化合物：其中X是其中R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，所有其它变量如本文所定义，它们在肺部炎症或支气管收缩治疗中的用途，以及 提供了组合物及其制备方法。
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12.发明申请Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties 审中-公开具有改善的药物性质的喹啉酮化合物的药学上可接受的盐公开(公告)号：US20050209247A1
公开(公告)日：2005-09-22
申请号：US10982543
申请日：2004-11-05
申请人： Shaopei Cai , Joyce Chou , Eric Harwood , Timothy Machajewski , David Ryckman , Xiao Shang , Shuguang Zhu , Augustus Okhamafe , Marc Tesconi
发明人： Shaopei Cai , Joyce Chou , Eric Harwood , Timothy Machajewski , David Ryckman , Xiao Shang , Shuguang Zhu , Augustus Okhamafe , Marc Tesconi
IPC分类号： A61K31/4375 , A61K31/4709 , A61K31/496 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D487/08 , C07D43/14
CPC分类号： C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C51/412 , C07C59/08
摘要： A lacate salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R1-R9 and R12-R14 are as defined herein
摘要翻译： 式I化合物的拉坦酸盐或该化合物的互变异构体，其中式I具有以下结构，R 1〜9和R 12， R 14和R 14如本文所定义
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13.发明申请PHARMACEUTICALLY ACCEPTABLE SALTS OF QUINOLINONE COMPOUNDS HAVING IMPROVED PHARMACEUTICAL PROPERTIES 审中-公开具有改进的药物性质的喹诺酮化合物的药学上可接受的盐公开(公告)号：US20140303182A1
公开(公告)日：2014-10-09
申请号：US14215437
申请日：2014-03-17
申请人： Shaopei Cai , Joyce Chou , Eric Harwood , Timothy Machajewski , David Ryckman , Xiao Shang , Shuguang Zhu , Augustus Okhamate , Marc S. Tesconi
发明人： Shaopei Cai , Joyce Chou , Eric Harwood , Timothy Machajewski , David Ryckman , Xiao Shang , Shuguang Zhu , Augustus Okhamate , Marc S. Tesconi
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C51/412 , C07C59/08
摘要： A lacate salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R1-R9 and R12-R14 are as defined herein
摘要翻译： 式I化合物或化合物的互变异构体的拉坦酸盐，其中式I具有以下结构，并且R 1 -R 9和R 12 -R 14如本文所定义
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14.发明申请Pharmaceutically Acceptable Salts of Quinolinone Compounds Having Improved Pharmaceutical Properties 审中-公开具有改善药物性质的喹啉酮化合物的药学上可接受的盐公开(公告)号：US20130338171A1
公开(公告)日：2013-12-19
申请号：US13956463
申请日：2013-08-01
申请人： Shaopei Cai , Joyce Chou , Eric Harwood , Timothy Machajewski , David Ryckman , Xiao Shang , Shuguang Zhu , Augustus Okhamafe , Marc S. Tesconi
发明人： Shaopei Cai , Joyce Chou , Eric Harwood , Timothy Machajewski , David Ryckman , Xiao Shang , Shuguang Zhu , Augustus Okhamafe , Marc S. Tesconi
IPC分类号： C07D401/04 , C07C51/41 , C07C59/08
CPC分类号： C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C51/412 , C07C59/08
摘要： A lacate salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R1-R9 and R12-R14 are as defined herein
摘要翻译： 式I化合物或化合物的互变异构体的拉坦酸盐，其中式I具有以下结构，并且R 1 -R 9和R 12 -R 14如本文所定义
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公开(公告)号：US08450490B2
公开(公告)日：2013-05-28
申请号：US13619792
申请日：2012-09-14
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： C07D513/02
CPC分类号： C07D471/04
摘要： This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.
摘要翻译： 本发明提供下式的化合物：其中X是其中R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，所有其它变量如本文所定义，它们在肺部炎症或支气管收缩治疗中的用途，以及 提供了组合物及其制备方法。
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16.发明申请公开(公告)号：US20130018058A1
公开(公告)日：2013-01-17
申请号：US13309879
申请日：2011-12-02
申请人： Shaopei Cai , Joyce Chou , Eric Harwood , Timothy Machajewski , David Ryckman , Xiao Shang , Shuguang Zhu , Augustus O. Okhamafe , Marc S. Tesconi
发明人： Shaopei Cai , Joyce Chou , Eric Harwood , Timothy Machajewski , David Ryckman , Xiao Shang , Shuguang Zhu , Augustus O. Okhamafe , Marc S. Tesconi
IPC分类号： C07D401/14 , A61P43/00 , A61K31/496
CPC分类号： C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C51/412 , C07C59/08
摘要： A lacate salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R1-R9 and R12-R14 are as defined herein
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