公开(公告)号：US20110250268A1

公开(公告)日：2011-10-13

申请号：US13089535

申请日：2011-04-19

申请人： Aleksey Kostadinov ,  David Ayelet ,  Sabina Glozman ,  Tal Atarot

发明人： Aleksey Kostadinov ,  David Ayelet ,  Sabina Glozman ,  Tal Atarot

IPC分类号： A61K9/48 ,  A61K31/4439 ,  A61K31/437 ,  A61K31/4184 ,  A61P1/04 ,  A61K31/454 ,  A61K31/45 ,  A61K31/5375 ,  A61K38/12 ,  A61K9/00 ,  A61K31/7048

CPC分类号： A61K9/0004 ,  A61K9/0019 ,  A61K9/2081 ,  A61K9/4808 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5084 ,  A61K31/19 ,  A61K31/191 ,  A61K31/4439 ,  A61K45/06 ,  A61K47/12 ,  A61K2300/00

摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.

公开(公告)号：US07803817B2

公开(公告)日：2010-09-28

申请号：US11191688

申请日：2005-07-27

申请人： Aleksey Kostadinov ,  Ayelet David ,  Sabina Glozman

发明人： Aleksey Kostadinov ,  Ayelet David ,  Sabina Glozman

IPC分类号： A61K31/4439 ,  A61K31/194

CPC分类号： A61K31/19 ,  A61K9/2081 ,  A61K31/4439 ,  A61K47/12 ,  A61K2300/00

摘要： The present invention is related to oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and succinc acid as a parietal cell activator in the gastric lumen. The compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.

摘要翻译： 本发明涉及含有作为胃酸分泌抑制剂的不可逆胃H + / K + -ATP酶质子泵抑制剂（PPI）和胃肠腔中作为壁细胞活化剂的琥珀酸的口服组合物。 本发明的组合物能够增强胃中PPI的抗酸活性。 本发明还涉及使用这种组合物以减少哺乳动物胃酸分泌的方法。

公开(公告)号：US20080248109A1

公开(公告)日：2008-10-09

申请号：US12120599

申请日：2008-05-14

申请人： Aleksey Kostadinov ,  David Ayelet ,  Sabina Glozman ,  Tal Atarot

发明人： Aleksey Kostadinov ,  David Ayelet ,  Sabina Glozman ,  Tal Atarot

IPC分类号： A61K9/48 ,  A61K31/191 ,  A61P1/04

CPC分类号： A61K9/0004 ,  A61K9/0019 ,  A61K9/2081 ,  A61K9/4808 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5084 ,  A61K31/19 ,  A61K31/191 ,  A61K31/4439 ,  A61K45/06 ,  A61K47/12 ,  A61K2300/00

摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.

摘要翻译： 本发明涉及新的口服组合物，其包含作为胃酸分泌抑制剂的不可逆的胃H + / 小羧酸分子作为胃腔中的壁细胞激活剂。 意外地，本发明的组合物能够增强胃中PPI的抗酸活性。 本发明还涉及使用这种组合物以减少哺乳动物胃酸分泌的方法。

公开(公告)号：US20060135406A1

公开(公告)日：2006-06-22

申请号：US11351001

申请日：2006-02-09

申请人： Sabina Glozman ,  Ayelet David ,  Lada Paul

发明人： Sabina Glozman ,  Ayelet David ,  Lada Paul

IPC分类号： A61K38/54 ,  A61K31/4439

CPC分类号： A61K38/2207 ,  A61K31/4439

摘要： The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor, pentagastrin (PG) or a PG analogue as an activator of parietal cells in the gastric lumen. In a preferred embodiment, the composition further comprises at least one agent that preserves the availability of PG in the gastric fluids, thus enabling PG to act locally in the stomach. Unexpectedly, the compositions of the present invention exhibit anti-acid activity locally in the stomach that is meal-independent, exhibit fast onset and prolonged inhibition of acid secretion.

摘要翻译： 本发明涉及包含作为胃酸分泌抑制剂的不可逆胃H + / H + + / - ATP酶质粒泵抑制剂（PPI）的新型口服组合物，五加胃泌素（PG ）或PG类似物作为胃内腔壁细胞的激活剂。 在优选的实施方案中，组合物还包含至少一种保留胃液中PG的可用性的试剂，从而使PG能够局部地在胃中起作用。 意外地，本发明的组合物在胃中局部表现出与膳食无关的抗酸活性，表现出快速发作和延长的酸分泌抑制。