公开(公告)号：US20100124534A1

公开(公告)日：2010-05-20

申请号：US12503512

申请日：2009-07-15

Applicant: Richard Harrop ,  William Shingler ,  Stuart Naylor ,  Michael McDonald

Inventor： Richard Harrop ,  William Shingler ,  Stuart Naylor ,  Michael McDonald

IPC: A61K49/00 ,  A61P37/04

CPC classification number: G01N33/6854 ,  A61K39/0011 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C12N2799/023 ,  G01N33/574 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2800/52

Abstract: The present invention provides a method of monitoring the efficacy of an immunotherapy in a mammalian subject, wherein the subject has been administered an immunotherapy, wherein the immunotherapy comprises a viral vector containing a polynucleotide encoding an antigen, wherein the viral vector is capable of transducing cells in the mammalian subject to cause the cells to express the antigen; the method comprising: (b) measuring, from a biological sample isolated from the subject, an immune response of the subject to the antigen and comparing the immune response of the subject to the antigen to a reference measurement of immune response to the antigen; (c) measuring, from a biological sample isolated from the subject, an immune response of the subject to the viral vector and comparing the immune response of the subject to the viral vector to a reference measurement of immune response to the viral vector; and (d) determining efficacy based on the comparisons of (b) and (c), wherein an elevated immune response to the antigen and a reduced immune response to the viral vector are indicative of an effective immunotherapy.

Abstract translation: 本发明提供了监测哺乳动物受试者的免疫治疗功效的方法，其中所述受试者已经进行免疫治疗，其中所述免疫疗法包含含有编码抗原的多核苷酸的病毒载体，其中所述病毒载体能够转导细胞 在哺乳动物受试者中使细胞表达抗原; 该方法包括：（b）从分离自受试者的生物样品中测量受试者对抗原的免疫应答并将受试者与抗原的免疫应答与抗原的免疫应答的参考测量进行比较; （c）从分离自受试者的生物样品中测量受试者对病毒载体的免疫应答，并将受试者与病毒载体的免疫应答与对病毒载体的免疫应答的参考测量进行比较; 和（d）基于（b）和（c）的比较确定功效，其中对抗原的免疫应答升高和对病毒载体的免疫应答降低是指示有效的免疫治疗。

公开(公告)号：US08783375B2

公开(公告)日：2014-07-22

申请号：US13204088

申请日：2011-08-05

Applicant: Matthew Stuart Naylor ,  David Daniel Seib ,  Nicholas Carl Broberg

Inventor： Matthew Stuart Naylor ,  David Daniel Seib ,  Nicholas Carl Broberg

IPC: A01B15/16

CPC classification number: A01B23/06 ,  A01C5/062

Abstract: A scraper for a coulter assembly is provided. One coulter assembly includes a scraper having an upper leading edge section positioned adjacent to a central portion of a disc blade and configured to contact the disc blade while the disc blade is substantially undeflected, and a lower leading edge section positioned adjacent to an outer portion of the disc blade and configured to contact the disc blade while the disc blade is substantially undeflected. The upper leading edge section and the lower leading edge section are configured to maintain contact with the disc blade as the outer portion of the disc blade is deflected relative to the central portion of the disc blade along a substantially arcuate path.

Abstract translation: 提供了一个用于仓库组件的刮刀。 一个绞盘组件包括刮刀，其具有与盘片的中心部分相邻的上前缘部分，并且构造成在盘片基本上不偏转时与盘片接触，并且下前缘部分定位成邻近盘片的外部 所述盘片并且构造成在所述盘片基本上未偏转时接触所述盘片。 上前缘部分和下前缘部分构造成保持与盘片的接触，因为盘片的外部部分相对于盘片的中心部分沿着基本上弧形的路径偏转。

公开(公告)号：US20050124564A1

公开(公告)日：2005-06-09

申请号：US10818720

申请日：2004-04-05

Applicant: Katie Binley ,  Susan Kingsman ,  Stuart Naylor

Inventor： Katie Binley ,  Susan Kingsman ,  Stuart Naylor

IPC: A61K48/00 ,  C07K14/505 ,  C12N15/864 ,  C12N15/861 ,  C12N15/867

CPC classification number: C12N15/86 ,  A61K31/70 ,  A61K38/1816 ,  A61K48/00 ,  C07K14/505 ,  C12N2750/14143 ,  C12N2799/025 ,  C12N2830/002 ,  C12N2830/008

Abstract: Disclosed is a viral vector containing a nucleic acid sequence encoding erythropoietin (Epo), in operable linkage with an HRE expression control sequence, as well as uses of the vector; for instance, in preparing a medicament. Also provided are methods for treating anemia, can involve administering the vector to a patient, wherein expression of Epo is physiologically regulated such that hematocrit levels of the patient are corrected and maintained.

Abstract translation: 公开了含有编码红细胞生成素（Epo）的核酸序列的病毒载体，其与HRE表达控制序列可操作地连接，以及载体的用途; 例如，在制备药物中。 还提供了治疗贫血的方法，可以涉及向患者施用载体，其中Epo的表达在生理学上被调节，使得患者的血细胞比容水平被校正和维持。

公开(公告)号：US09212786B2

公开(公告)日：2015-12-15

申请号：US13261113

申请日：2010-06-30

Applicant: Stuart Naylor

Inventor： Stuart Naylor

IPC: H01L21/673 ,  F17D1/04

CPC classification number: F17D1/04 ,  H01L21/67393

Abstract: Apparatus for purging containers for the storage of sensitive materials is described. It includes means to connect a source of compressed purge gas to a purge gas inlet (2) on a container (1), including a pneumatically operated valve (6) adapted to allow purge gas to pass from the source to the inlet and a timing device (9) associated with the valve (6) and adapted to turn off the gas flow after a given time, and including means to vary the time between commencement and cessation of gas flow. The timing device is preferably one which operates on a pneumatic or clockwork basis, enabling the apparatus to operate without any electrical power supply, driven by the purge gas pressure alone. This enables the construction of a simple reliable unit, at a cost even enabling the unit to be incorporated into the container itself if desired. The use of a pneumatically operated valve enables portable apparatus to be designed with low power use if it includes e.g. electronic sensors to measure a property of the purge gas being exhausted from the container.

Abstract translation: 描述了用于清洁用于存储敏感材料的容器的装置。 其包括将压缩的净化气体源连接到容器（1）上的吹扫气体入口（2）的装置，所述吹扫气体入口（2）包括气动操作的阀（6），其适于使吹扫气体从所述源传送到所述入口， 与阀（6）相关联并适于在给定时间之后关闭气流的装置（9），并且包括改变气体流量的开始和停止之间的时间的装置。 定时装置优选是以气动或发条为基础运行的定时装置，使得装置能够在没有任何电力供应的情况下操作，仅由吹扫气体压力驱动。 这使得能够构造简单可靠的单元，但是如果需要，甚至能够将该单元结合到容器本身中。 使用气动阀使得便携式设备可以被设计成具有低功率使用，如果它包括例如 用于测量从容器中排出的净化气体的性质的电子传感器。

公开(公告)号：US20120096740A1

公开(公告)日：2012-04-26

申请号：US13261113

申请日：2010-06-30

Applicant: Stuart Naylor

Inventor： Stuart Naylor

IPC: F26B21/06

CPC classification number: F17D1/04 ,  H01L21/67393

Abstract: Apparatus for purging containers for the storage of sensitive materials is described. It includes means to connect a source of compressed purge gas to a purge gas inlet (2) on a container (1), including a pneumatically operated valve (6) adapted to allow purge gas to pass from the source to the inlet and a timing device (9) associated with the valve (6) and adapted to turn off the gas flow after a given time, and including means to vary the time between commencement and cessation of gas flow. The timing device is preferably one which operates on a pneumatic or clockwork basis, enabling the apparatus to operate without any electrical power supply, driven by the purge gas pressure alone. This enables the construction of a simple reliable unit, at a cost even enabling the unit to be incorporated into the container itself if desired. The use of a pneumatically operated valve enables portable apparatus to be designed with low power use if it includes e.g. electronic sensors to measure a property of the purge gas being exhausted from the container.

Abstract translation: 描述了用于清洁用于存储敏感材料的容器的装置。 其包括将压缩的净化气体源连接到容器（1）上的吹扫气体入口（2）的装置，所述吹扫气体入口（2）包括气动操作的阀（6），其适于使吹扫气体从所述源传送到所述入口， 与阀（6）相关联并适于在给定时间之后关闭气流的装置（9），并且包括改变气体流量的开始和停止之间的时间的装置。 定时装置优选是以气动或发条为基础运行的定时装置，使得装置能够在没有任何电力供应的情况下操作，仅由吹扫气体压力驱动。 这使得能够构造简单可靠的单元，但是如果需要，甚至能够将该单元结合到容器本身中。 使用气动阀使得便携式设备可以被设计成具有低功率使用，如果它包括例如 用于测量从容器中排出的净化气体的性质的电子传感器。