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公开(公告)号：US20080099348A1
公开(公告)日：2008-05-01
申请号：US11883296
申请日：2006-01-30
Applicant: Stuart Naylor
Inventor： Stuart Naylor
IPC: B65D81/20
CPC classification number: G01N1/2226 , B65D81/2076 , G01N2001/2241
Abstract: Apparatus is described for storing sensitive materials in containers (32) which are sealed and in which the internal atmosphere may be purged by flushing with an inert gas fed in from a purger unit (30) via a suitable feed lead (35). The gas exhausted from inside the container (32) is fed back into the purge unit (30) and then checked against a desired parameter, for example oxygen concentration, until the value of that parameter reaches a desired level. Purging may then be stopped and the container left sealed, preferably at a slight over pressure relative to the ambient atmosphere. The use of a separate purge unit enables many containers to be sequentially and effectively processed. The containers are particularly useful for storing sensitive chemical and biological samples.
Abstract translation: 描述了用于将敏感材料存储在容器（32）中的装置，所述容器（32）被密封，并且可以通过经由适当的进料引线（35）从净化器单元（30）进料的惰性气体冲洗来清洗内部气氛。 从容器（32）内部排出的气体被反馈到清洗单元（30）中，然后检查所期望的参数，例如氧浓度，直到该参数的值达到期望水平。 然后可以停止清洗，并且容器保持密封，优选地相对于环境气氛稍微过压。 使用单独的吹扫单元可以顺序地和有效地处理许多容器。 这些容器特别适用于储存敏感的化学和生物样品。
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2.发明授权Lentiviral-mediated growth factor gene therapy for neurodegenerative diseases 失效慢病毒介导的神经变性疾病生长因子基因治疗公开(公告)号：US06800281B2
公开(公告)日：2004-10-05
申请号：US10008610
申请日：2001-11-08
Applicant: Patrick Aebischer , Susan Mary Kingsman , Stuart Naylor , Nicholas Mazarakis
Inventor： Patrick Aebischer , Susan Mary Kingsman , Stuart Naylor , Nicholas Mazarakis
IPC: A61K4800
CPC classification number: C12N15/86 , A61K48/00 , C07K14/4756 , C12N2740/15043
Abstract: Disclosed and claimed are methods for treating or preventing neurodegenerative diseases, conditions or maladies or symptoms or physiology associated therewith, such as treating or preventing Parkinson's disease or symptoms or physiology associated therewith such as motor deficits or nigrostriatal degeneration; or, for inducing nigrostriatal regeneration. Advantageously, the methods involve administering a lentiviral vector that expresses GDNF, such as human GDNF, or a variant, homolog, analog or derivative thereof.
Abstract translation: 公开并要求保护的是用于治疗或预防神经变性疾病，病症或疾病或症状或与之相关的生理学的方法，例如治疗或预防帕金森病或与之相关的症状或生理学，例如运动缺陷或黑质纹状体变性; 或用于诱导黑质纹状体再生。 有利地，所述方法包括施用表达GDNF的慢病毒载体，例如人GDNF，或其变体，同系物，类似物或衍生物。
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公开(公告)号：US09433139B2
公开(公告)日：2016-09-06
申请号：US13277689
申请日：2011-10-20
Applicant: Cameron Wade Stettner , Matthew Stuart Naylor , Terrance Alan Friggstad
IPC: A01B73/04
CPC classification number: A01B73/044
Abstract: A wing locking assembly for an agricultural implement is provided. One agricultural implement includes a first frame section having a mounted bracket and a second frame section pivotally coupled to the first frame section. A cam is mounted to the second frame section. The implement includes an actuating cylinder having a first end pivotally coupled to the second frame section, and a second end disposed within a slot of the bracket. The implement also includes a locking mechanism rotatably coupled to the bracket. The locking mechanism includes a first end configured to engage the second end of the actuating cylinder, and a second end configured to abut the cam. The locking mechanism is configured to drive the second end of the actuating cylinder into a desired position within the slot upon contact between the cam and the second end of the locking mechanism.
Abstract translation: 提供了一种用于农具的机翼锁定组件。 一个农用机具包括具有安装支架的第一框架部分和枢转地联接到第一框架部分的第二框架部分。 凸轮安装到第二框架部分。 所述工具包括致动缸，所述致动缸具有枢转地联接到所述第二框架部分的第一端和设置在所述支架的槽内的第二端。 该工具还包括可旋转地联接到支架的锁定机构。 锁定机构包括构造成接合致动缸的第二端的第一端和构造成抵靠凸轮的第二端。 锁定机构构造成在凸轮和锁定机构的第二端之间接触时将致动缸的第二端驱动到槽内的期望位置。
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公开(公告)号：US08904945B2
公开(公告)日：2014-12-09
申请号：US13297055
申请日：2011-11-15
Applicant: Matthew Stuart Naylor , Robin Bruno Schilling
Inventor： Matthew Stuart Naylor , Robin Bruno Schilling
CPC classification number: A01C5/068 , A01B15/16 , A01B23/06 , A01B49/06 , A01C5/064 , A01C7/06 , A01C7/201 , A01C7/203 , A01C7/206
Abstract: A double shoot coulter assembly for an agricultural implement includes a packer wheel. The packer wheel is disposed behind a soil engaging blade. The packer wheel is configured to press soil displaced by the soil engaging blade into trenches formed by the soil engaging blade and a disc blade. A centerline of the packer wheel extends adjacent to a soil displacing side of the soil engaging blade.
Abstract translation: 一种用于农具的双头仓库组件包括封隔器轮。 封隔器轮设置在土壤接合叶片后面。 封隔器轮构造成将由土壤接合叶片移动的土壤压入由土壤接合叶片和盘片形成的沟槽中。 封隔器轮的中心线邻近土壤接合叶片的土壤位移侧延伸。
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公开(公告)号：US08642274B2
公开(公告)日：2014-02-04
申请号：US12503512
申请日：2009-07-15
Applicant: Richard Harrop , William Shingler , Stuart Naylor , Michael McDonald
Inventor： Richard Harrop , William Shingler , Stuart Naylor , Michael McDonald
IPC: G01N33/53
CPC classification number: G01N33/6854 , A61K39/0011 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C12N2799/023 , G01N33/574 , G01N33/57419 , G01N33/57438 , G01N2800/52
Abstract: The present invention provides a method of monitoring the efficacy of an immunotherapy in a mammalian subject, wherein the subject has been administered an immunotherapy, wherein the immunotherapy comprises a viral vector containing a polynucleotide encoding an antigen, wherein the viral vector is capable of transducing cells in the mammalian subject to cause the cells to express the antigen; the method comprising: (b) measuring, from a biological sample isolated from the subject, an immune response of the subject to the antigen and comparing the immune response of the subject to the antigen to a reference measurement of immune response to the antigen; (c) measuring, from a biological sample isolated from the subject, an immune response of the subject to the viral vector and comparing the immune response of the subject to the viral vector to a reference measurement of immune response to the viral vector; and (d) determining efficacy based on the comparisons of (b) and (c), wherein an elevated immune response to the antigen and a reduced immune response to the viral vector are indicative of an effective immunotherapy.
Abstract translation: 本发明提供了监测哺乳动物受试者的免疫治疗功效的方法，其中所述受试者已经进行免疫治疗，其中所述免疫疗法包含含有编码抗原的多核苷酸的病毒载体，其中所述病毒载体能够转导细胞 在哺乳动物受试者中使细胞表达抗原; 该方法包括：（b）从分离自受试者的生物样品中测量受试者对抗原的免疫应答并将受试者与抗原的免疫应答与抗原的免疫应答的参考测量进行比较; （c）从分离自受试者的生物样品中测量受试者对病毒载体的免疫应答，并将受试者与病毒载体的免疫应答与对病毒载体的免疫应答的参考测量进行比较; 和（d）基于（b）和（c）的比较确定功效，其中对抗原的免疫应答升高和对病毒载体的免疫应答降低是指示有效的免疫治疗。
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Patent Agency Ranking
公开(公告)号：US20130118392A1
公开(公告)日：2013-05-16
申请号：US13297055
申请日：2011-11-15
Applicant: Matthew Stuart Naylor , Robin Bruno Schilling
Inventor： Matthew Stuart Naylor , Robin Bruno Schilling
CPC classification number: A01C5/068 , A01B15/16 , A01B23/06 , A01B49/06 , A01C5/064 , A01C7/06 , A01C7/201 , A01C7/203 , A01C7/206
Abstract: A double shoot coulter assembly for an agricultural implement includes a packer wheel. The packer wheel is disposed behind a soil engaging blade. The packer wheel is configured to press soil displaced by the soil engaging blade into trenches formed by the soil engaging blade and a disc blade. A centerline of the packer wheel extends adjacent to a soil displacing side of the soil engaging blade.
Abstract translation: 一种用于农具的双头仓库组件包括封隔器轮。 封隔器轮设置在土壤接合叶片后面。 封隔器轮构造成将由土壤接合叶片移动的土壤压入由土壤接合叶片和盘片形成的沟槽中。 封隔器轮的中心线邻近土壤接合叶片的土壤位移侧延伸。
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公开(公告)号：US07878112B2
公开(公告)日：2011-02-01
申请号：US11883296
申请日：2006-01-30
Applicant: Stuart Naylor
Inventor： Stuart Naylor
CPC classification number: G01N1/2226 , B65D81/2076 , G01N2001/2241
Abstract: Apparatus is described for storing sensitive materials in containers (32) which are sealed and in which the internal atmosphere may be purged by flushing with an inert gas fed in from a purger unit (30) via a suitable feed lead (35). The gas exhausted from inside the container (32) is fed back into the purge unit (30) and then checked against a desired parameter, for example oxygen concentration, until the value of that parameter reaches a desired level. Purging may then be stopped and the container left sealed, preferably at a slight over pressure relative to the ambient atmosphere. The use of a separate purge unit enables many containers to be sequentially and effectively processed. The containers are particularly useful for storing sensitive chemical and biological samples.
Abstract translation: 描述了用于将敏感材料存储在容器（32）中的装置，所述容器（32）被密封，并且可以通过经由适当的进料引线（35）从净化器单元（30）进料的惰性气体冲洗来清洗内部气氛。 从容器（32）内部排出的气体被反馈到清洗单元（30）中，然后检查所期望的参数，例如氧浓度，直到该参数的值达到期望水平。 然后可以停止清洗，并且容器保持密封，优选地相对于环境气氛稍微过压。 使用单独的吹扫单元可以顺序地和有效地处理许多容器。 这些容器特别适用于储存敏感的化学和生物样品。
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公开(公告)号：US20080125387A1
公开(公告)日：2008-05-29
申请号：US11705645
申请日：2007-02-12
Applicant: Katie Mary Binley , Susan Mary Kingsman , Stuart Naylor
Inventor： Katie Mary Binley , Susan Mary Kingsman , Stuart Naylor
CPC classification number: C12N15/86 , A61K31/70 , A61K38/1816 , A61K48/00 , C07K14/505 , C12N2750/14143 , C12N2799/025 , C12N2830/002 , C12N2830/008
Abstract: Disclosed is a viral vector containing a nucleic acid sequence encoding erythropoietin (Epo), in operable linkage with an HRE expression control sequence, as well as uses of the vector; for instance, in preparing a medicament. Also provided are methods for treating anemia, can involve administering the vector to a patient, wherein expression of Epo is physiologically regulated such that hematocrit levels of the patient are corrected and maintained.
Abstract translation: 公开了含有编码红细胞生成素（Epo）的核酸序列的病毒载体，其与HRE表达控制序列可操作地连接，以及载体的用途; 例如，在制备药物中。 还提供了治疗贫血的方法，可以涉及向患者施用载体，其中Epo的表达在生理学上被调节，使得患者的血细胞比容水平被校正和维持。
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公开(公告)号：US20130098645A1
公开(公告)日：2013-04-25
申请号：US13277689
申请日：2011-10-20
Applicant: Cameron Wade Stettner , Matthew Stuart Naylor , Terrance Alan Friggstad
IPC: A01B73/04
CPC classification number: A01B73/044
Abstract: A wing locking assembly for an agricultural implement is provided. One agricultural implement includes a first frame section having a mounted bracket and a second frame section pivotally coupled to the first frame section. A cam is mounted to the second frame section. The implement includes an actuating cylinder having a first end pivotally coupled to the second frame section, and a second end disposed within a slot of the bracket. The implement also includes a locking mechanism rotatably coupled to the bracket. The locking mechanism includes a first end configured to engage the second end of the actuating cylinder, and a second end configured to abut the cam. The locking mechanism is configured to drive the second end of the actuating cylinder into a desired position within the slot upon contact between the cam and the second end of the locking mechanism.
Abstract translation: 提供了一种用于农具的机翼锁定组件。 一个农用机具包括具有安装支架的第一框架部分和枢转地联接到第一框架部分的第二框架部分。 凸轮安装到第二框架部分。 所述工具包括致动缸，所述致动缸具有枢转地联接到所述第二框架部分的第一端和设置在所述支架的槽内的第二端。 该工具还包括可旋转地联接到支架的锁定机构。 锁定机构包括构造成接合致动缸的第二端的第一端和构造成抵靠凸轮的第二端。 锁定机构构造成在凸轮和锁定机构的第二端之间接触时将致动缸的第二端驱动到槽内的期望位置。
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公开(公告)号：US20130032366A1
公开(公告)日：2013-02-07
申请号：US13204088
申请日：2011-08-05
Applicant: Matthew Stuart Naylor , David Daniel Seib , Nicholas Carl Broberg
Inventor： Matthew Stuart Naylor , David Daniel Seib , Nicholas Carl Broberg
Abstract: A scraper for a coulter assembly is provided. One coulter assembly includes a scraper having an upper leading edge section positioned adjacent to a central portion of a disc blade and configured to contact the disc blade while the disc blade is substantially undeflected, and a lower leading edge section positioned adjacent to an outer portion of the disc blade and configured to contact the disc blade while the disc blade is substantially undeflected. The upper leading edge section and the lower leading edge section are configured to maintain contact with the disc blade as the outer portion of the disc blade is deflected relative to the central portion of the disc blade along a substantially arcuate path.
Abstract translation: 提供了一个用于仓库组件的刮刀。 一个绞盘组件包括刮刀，其具有与盘片的中心部分相邻的上前缘部分，并且构造成在盘片基本上不偏转时与盘片接触，并且下前缘部分定位成邻近盘片的外部 所述盘片并且构造成在所述盘片基本上未偏转时接触所述盘片。 上前缘部分和下前缘部分构造成保持与盘片的接触，因为盘片的外部部分相对于盘片的中心部分沿着基本上弧形的路径偏转。
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