公开(公告)号：US07405299B2

公开(公告)日：2008-07-29

申请号：US10535381

申请日：2003-11-24

Applicant: Douglas Wade Beight ,  Timothy Paul Burkholder ,  Todd Vincent Decollo ,  Alexander Glenn Godfrey ,  Charles Raymond Heap ,  Chi-Hsin Richard King ,  Hong-Yu Li ,  William Thomas McMillen ,  Jason Scott Sawyer ,  Yan Wang ,  Clive Gideon Diefenbacher ,  Thomas Albert Engler ,  Sushant Malhotra ,  Sreenivasa Reedy Mundla

Inventor： Douglas Wade Beight ,  Timothy Paul Burkholder ,  Todd Vincent Decollo ,  Alexander Glenn Godfrey ,  Charles Raymond Heap ,  Chi-Hsin Richard King ,  Hong-Yu Li ,  William Thomas McMillen ,  Jason Scott Sawyer ,  Yan Wang ,  Clive Gideon Diefenbacher ,  Thomas Albert Engler ,  Sushant Malhotra ,  Sreenivasa Reedy Mundla

IPC: C07D241/36 ,  C07D217/00 ,  C07D401/00

CPC classification number: C07D487/04

Abstract: The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.

Abstract translation: 本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。

公开(公告)号：US20060058295A1

公开(公告)日：2006-03-16

申请号：US10535381

申请日：2003-11-24

Applicant: Douglas Beight ,  Timothy Burkholder ,  Todd Decollo ,  Alexander Godfrey ,  Charles Heap ,  Chi-Hsin King ,  Hong-Yu Li ,  William McMillen ,  Jason Sawyer ,  Yan Wang ,  Clive Diefenbacher ,  Thomas Engler ,  Sushant Malhotra ,  Sreenivasa Mundla

Inventor： Douglas Beight ,  Timothy Burkholder ,  Todd Decollo ,  Alexander Godfrey ,  Charles Heap ,  Chi-Hsin King ,  Hong-Yu Li ,  William McMillen ,  Jason Sawyer ,  Yan Wang ,  Clive Diefenbacher ,  Thomas Engler ,  Sushant Malhotra ,  Sreenivasa Mundla

IPC: A61K31/5377 ,  A61K31/519 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D487/04

Abstract: The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.

Abstract translation: 本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。

公开(公告)号：US20080262004A1

公开(公告)日：2008-10-23

申请号：US11577094

申请日：2005-11-02

Applicant: Clive Gideon Diefenbacher ,  Thomas Albert Engler ,  Hong-Yu Li ,  Sushant Malhotra ,  Jason Scott Sawyer ,  Yan Wang

Inventor： Clive Gideon Diefenbacher ,  Thomas Albert Engler ,  Hong-Yu Li ,  Sushant Malhotra ,  Jason Scott Sawyer ,  Yan Wang

IPC: A61K31/519 ,  C07D471/04 ,  A61K31/437 ,  A61P25/28 ,  A61P35/00 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention is directed to inhibitors of TGF-β of Formula I:

Abstract translation: 本发明涉及式I的TGF-β抑制剂：