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公开(公告)号：US20060058295A1
公开(公告)日：2006-03-16
申请号：US10535381
申请日：2003-11-24
申请人： Douglas Beight , Timothy Burkholder , Todd Decollo , Alexander Godfrey , Charles Heap , Chi-Hsin King , Hong-Yu Li , William McMillen , Jason Sawyer , Yan Wang , Clive Diefenbacher , Thomas Engler , Sushant Malhotra , Sreenivasa Mundla
发明人： Douglas Beight , Timothy Burkholder , Todd Decollo , Alexander Godfrey , Charles Heap , Chi-Hsin King , Hong-Yu Li , William McMillen , Jason Sawyer , Yan Wang , Clive Diefenbacher , Thomas Engler , Sushant Malhotra , Sreenivasa Mundla
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/4745 , C07D471/02
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译： 本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。
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公开(公告)号：US20050090483A1
公开(公告)日：2005-04-28
申请号：US10506459
申请日：2003-03-04
申请人： Thomas Engler , Timothy Burkholder , Joshua Clayton , Clive Diefenbacher , Kelly Furness , James Henry , Yihong Li , Sushant Malhotra , Angela Marquart , Johnathan McLean , David Mendel , Jon Reel
发明人： Thomas Engler , Timothy Burkholder , Joshua Clayton , Clive Diefenbacher , Kelly Furness , James Henry , Yihong Li , Sushant Malhotra , Angela Marquart , Johnathan McLean , David Mendel , Jon Reel
IPC分类号： A61K31/407 , A61K31/4355 , A61K31/4745 , A61K31/55 , A61K31/5513 , A61P3/10 , A61P25/08 , A61P25/28 , A61P43/00 , C07D471/06 , C07D487/06 , C07D498/06 , C07D519/00 , A61K31/551 , C07D487/14
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：US20050288321A1
公开(公告)日：2005-12-29
申请号：US10506029
申请日：2003-03-05
申请人： Pamela Albaugh , Jochen Ammenn , Timothy Burkholder , Joshu Clayton , Scott Conner , Brian Cunningham , Thomas Engler , Kelly Furness , James Henry , Sushant Malhotra , Mark Joseph Tebbe
发明人： Pamela Albaugh , Jochen Ammenn , Timothy Burkholder , Joshu Clayton , Scott Conner , Brian Cunningham , Thomas Engler , Kelly Furness , James Henry , Sushant Malhotra , Mark Joseph Tebbe
IPC分类号： C07D491/052 , A61K31/404 , A61K31/405 , A61K31/4355 , A61K31/437 , A61K31/438 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/4741 , A61K31/4745 , A61K31/496 , A61K31/506 , A61P3/10 , A61P5/50 , A61P25/28 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D451/04 , C07D471/02 , C07D471/04 , C07D491/04 , C07D43/14
CPC分类号： C07D451/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/04
摘要： The present invention provides kinase inhibitors of Formula (I).
摘要翻译： 本发明提供式（I）的激酶抑制剂。
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公开(公告)号：US20080262004A1
公开(公告)日：2008-10-23
申请号：US11577094
申请日：2005-11-02
申请人： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
发明人： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
IPC分类号： A61K31/519 , C07D471/04 , A61K31/437 , A61P25/28 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention is directed to inhibitors of TGF-β of Formula I:
摘要翻译： 本发明涉及式I的TGF-β抑制剂：
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公开(公告)号：US07405299B2
公开(公告)日：2008-07-29
申请号：US10535381
申请日：2003-11-24
申请人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
发明人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
IPC分类号： C07D241/36 , C07D217/00 , C07D401/00
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译： 本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。
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公开(公告)号：US07511056B2
公开(公告)日：2009-03-31
申请号：US11577094
申请日：2005-11-02
申请人： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
发明人： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
IPC分类号： A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02 , C07D401/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention is directed to inhibitors of TGF-β of Formula I:
摘要翻译： 本发明涉及式I的TGF-β抑制剂：
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公开(公告)号：US20110207721A1
公开(公告)日：2011-08-25
申请号：US13100618
申请日：2011-05-04
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61K31/5517 , C07D487/04 , A61P3/10 , A61P25/28
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：US20110294792A1
公开(公告)日：2011-12-01
申请号：US13206057
申请日：2011-08-09
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61K31/551 , A61P19/08 , C07D487/04
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
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公开(公告)号：US20090105229A1
公开(公告)日：2009-04-23
申请号：US12333775
申请日：2008-12-12
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
IPC分类号： A61K31/5517 , C07D487/16
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：US08058425B2
公开(公告)日：2011-11-15
申请号：US13100618
申请日：2011-05-04
申请人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
发明人： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC分类号： A61P25/08 , A61K31/55 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式的激酶抑制剂。
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