公开(公告)号：US07087626B2

公开(公告)日：2006-08-08

申请号：US10477111

申请日：2002-05-13

Applicant: Douglas Wade Beight ,  Todd Vincent DeCollo ,  Alexander Glenn Godfrey ,  Theodore Goodson, Jr. ,  Hong-Yu Li ,  William Thomas McMillen ,  Shawn Christopher Miller ,  Jason Scott Sawyer ,  Edward C. R. Smith ,  Jonathan Michael Yingling

Inventor： Douglas Wade Beight ,  Todd Vincent DeCollo ,  Alexander Glenn Godfrey ,  Theodore Goodson, Jr. ,  Hong-Yu Li ,  William Thomas McMillen ,  Shawn Christopher Miller ,  Jason Scott Sawyer ,  Edward C. R. Smith ,  Jonathan Michael Yingling

IPC: A61K31/47 ,  C07D205/16 ,  C07D307/00 ,  C07D405/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S

Abstract translation: 新型吡唑衍生物化合物及其作为药剂的用途，特别是其作为TGF-β信号转导抑制剂的用途。 所公开的发明涉及结构（I）的化合物，其中（I）是四，五或六元饱和环，X是C，O或S

公开(公告)号：US07405299B2

公开(公告)日：2008-07-29

申请号：US10535381

申请日：2003-11-24

Applicant: Douglas Wade Beight ,  Timothy Paul Burkholder ,  Todd Vincent Decollo ,  Alexander Glenn Godfrey ,  Charles Raymond Heap ,  Chi-Hsin Richard King ,  Hong-Yu Li ,  William Thomas McMillen ,  Jason Scott Sawyer ,  Yan Wang ,  Clive Gideon Diefenbacher ,  Thomas Albert Engler ,  Sushant Malhotra ,  Sreenivasa Reedy Mundla

Inventor： Douglas Wade Beight ,  Timothy Paul Burkholder ,  Todd Vincent Decollo ,  Alexander Glenn Godfrey ,  Charles Raymond Heap ,  Chi-Hsin Richard King ,  Hong-Yu Li ,  William Thomas McMillen ,  Jason Scott Sawyer ,  Yan Wang ,  Clive Gideon Diefenbacher ,  Thomas Albert Engler ,  Sushant Malhotra ,  Sreenivasa Reedy Mundla

IPC: C07D241/36 ,  C07D217/00 ,  C07D401/00

CPC classification number: C07D487/04

Abstract: The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.

Abstract translation: 本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。