公开(公告)号：US20090239806A1

公开(公告)日：2009-09-24

申请号：US12063165

申请日：2006-08-08

申请人： Yasuharu Nishimura ,  Tetsuya Nakatsura ,  Hiroyuki Komori

发明人： Yasuharu Nishimura ,  Tetsuya Nakatsura ,  Hiroyuki Komori

IPC分类号： A61K38/08 ,  C07K7/06 ,  C12N5/08 ,  A61P35/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4725

摘要： It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B): (A) a peptide, which has the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide, which has an amino acid sequence comprising a substitution or addition of one or two amino acids with respect to the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has ability to induce killer T cells.

摘要翻译： 本发明的目的是鉴定可与HLA-A2结合并激活人类杀伤T细胞的磷脂酰肌醇蛋白聚糖-3衍生肽，以提供进行免疫治疗的手段，该免疫治疗能够靶向约40％ 患有几种类型癌症的日本患者，其高水平表达GPC3。 本发明提供下述（A）或（B）中任一项所述的肽：（A）具有SEQ ID NO：1〜3中任一项所示的氨基酸序列的肽; 或（B）肽，其具有相对于SEQ ID NO：1至3中任一项所示的氨基酸序列取代或添加一个或两个氨基酸的氨基酸序列，并且其具有 诱导杀伤T细胞。

公开(公告)号：US20060251666A1

公开(公告)日：2006-11-09

申请号：US10525831

申请日：2003-08-29

申请人： Tetsuya Nakatsura ,  Yasuharu Nishimura

发明人： Tetsuya Nakatsura ,  Yasuharu Nishimura

IPC分类号： A61K39/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C12N5/08 ,  C07K14/82

CPC分类号： G01N33/57419 ,  A61K39/00 ,  C07K14/4748 ,  G01N33/57438

摘要： An object of the present invention to provide: a human pancreatic cancer antigen and/or a human colon cancer antigen that can be applied to the diagnosis and/or treatment of various types of cancers or tumors including pancreatic cancer and colon cancer as representative examples; a gene encoding the same; an anti-cancer vaccine using the same; or the like. The present invention provides a cancer antigen comprising a protein having the amino acid sequence shown in SEQ ID NO: 1; a peptide comprising a portion of said protein and having immune-stimulating activity; an anti-cancer vaccine comprising said peptide; a DNA having the nucleotide sequence shown in SEQ ID NO: 2, or its complementary sequence or a part or full length of these sequence; an anti-cancer vaccine comprising said DNA; and use thereof.

摘要翻译： 本发明的目的是提供：可用于诊断和/或治疗包括胰腺癌和结肠癌的各种类型的癌症或肿瘤的人胰腺癌抗原和/或人结肠癌抗原作为代表性实例; 编码该基因的基因; 使用其的抗癌疫苗; 或类似物。 本发明提供包含具有SEQ ID NO：1所示氨基酸序列的蛋白质的癌抗原; 包含所述蛋白质的一部分并具有免疫刺激活性的肽; 包含所述肽的抗癌疫苗; 具有SEQ ID NO：2所示核苷酸序列的DNA或其互补序列或这些序列的部分或全长; 包含所述DNA的抗癌疫苗; 及其用途。