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11.发明授权Indol-6yl sulfonamide derivatives, their preparation and their use as 5-HT-6 as modulators 失效吲哚-6-基磺酰胺衍生物，它们的制备及其作为5-HT-6作为调节剂的用途公开(公告)号：US07462640B2
公开(公告)日：2008-12-09
申请号：US10566101
申请日：2004-07-29
Applicant: Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
Inventor： Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
IPC: A01N43/38 , A61K31/405 , C07D209/04
CPC classification number: C07D409/12 , C07D209/08 , C07D513/04
Abstract: The present invention refers to new sulfonamide derivatives, of general formula (Ia, Ib, Ic) optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, at any mixing ratio or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the process for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.
Abstract translation: 本发明涉及通式（Ia，Ib，Ic）的新型磺酰胺衍生物，其任选呈其立体异构体之一形式，优选对映异构体或非对映异构体，其外消旋体或其至少两种立体异构体的混合物的形式， 优选对映异构体或非对映体，以任何混合比例或其盐，优选相应的生理上可接受的盐或相应的溶剂合物; 其制备方法，作为人和/或兽医治疗剂中的药物的应用，以及含有它们的药物组合物。
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12.发明授权Indol-4 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators 失效Indol-4磺酰胺衍生物，它们的制备及其用途5-ht-6作为调节剂公开(公告)号：US08097643B2
公开(公告)日：2012-01-17
申请号：US10566164
申请日：2004-07-29
Applicant: Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
Inventor： Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
IPC: A61K31/404 , C07D209/10
CPC classification number: C07D409/12 , C07D209/08 , C07D513/04
Abstract: The present invention refers to new sulfonamide derivatives, of general formula (1a, 1b, 1c), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salt thereof s, preferably the corresponding, physiologically acceptable salt thereofs, or corresponding solvate thereofs; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.
Abstract translation: 本发明涉及通式（1a，1b，1c）的新型磺酰胺衍生物，任选呈其立体异构体之一形式，优选对映异构体或非对映异构体，其外消旋物或其至少两种立体异构体的混合物的形式 ，优选对映异构体或非对映体，以任何混合比例，或其盐，优选相应的生理上可接受的盐或其相应的溶剂合物; 其制备方法，作为人和/或兽医治疗剂中的药物的应用，以及含有它们的药物组合物。
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13.发明申请公开(公告)号：US20070203121A1
公开(公告)日：2007-08-30
申请号：US11673328
申请日：2007-02-09
Applicant: Ramon Merce Vidal , Alberto Dordal Zueras , Xavier Codony Soler
Inventor： Ramon Merce Vidal , Alberto Dordal Zueras , Xavier Codony Soler
IPC: A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/405 , C07D417/02 , C07D413/02 , C07D403/02
CPC classification number: C07D209/18 , C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
Abstract: The present invention relates to substituted indole compounds of general formula (I), a process for their preparation, medicaments comprising substituted indole compounds as well as the use of substituted indole compounds for the preparation medicaments, which are suitable e.g., for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via 5-HT6 receptors.
Abstract translation: 本发明涉及通式（I）的取代的吲哚化合物，其制备方法，包含取代的吲哚化合物的药物以及用于制备药物的取代的吲哚化合物的用途，其适用于预防和/ 或治疗至少部分通过5-HT 6受体介导的病症或疾病。
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Patent Agency Ranking
14.发明申请Active substance combination comprising a compound with npy receptor affinity and a compound with 5-ht6 receptor affinity 审中-公开包含具有npy受体亲和力的化合物和具有5-ht6受体亲和力的化合物的活性物质组合公开(公告)号：US20070059364A1
公开(公告)日：2007-03-15
申请号：US10566100
申请日：2004-07-29
Applicant: Antoni Torrens Jover , Josep Mas Prio , Alberto Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castrillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
Inventor： Antoni Torrens Jover , Josep Mas Prio , Alberto Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castrillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
IPC: A61K31/538 , A61K31/404 , A61K9/22
CPC classification number: A61K31/404 , A61K31/4045 , A61K31/536 , A61K2300/00
Abstract: The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.
Abstract translation: 本发明涉及包含至少一种具有神经肽Y受体亲和力的化合物和至少一种具有5-HT 6受体亲和力的化合物的活性物质组合物，包含所述活性物质组合的药物，以及所述活性物质组合物用于 制造药物。
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15.发明申请Indol-6 sulfonamide derivative, their preparation and their use 5-ht-6 as modulators 失效吲哚-6磺酰胺衍生物，它们的制备及其用途5-ht-6作为调节剂公开(公告)号：US20070043041A1
公开(公告)日：2007-02-22
申请号：US10566101
申请日：2004-07-29
Applicant: Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
Inventor： Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
IPC: A61K31/5377 , A61K31/498 , A61K31/454 , A61K31/405 , C07D413/02 , C07D403/02
CPC classification number: C07D409/12 , C07D209/08 , C07D513/04
Abstract: The present invention refers to new sulfonamide derivatives, of general formula (la, lb, lc) optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, at any mixing ratio or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the process for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.
Abstract translation: 本发明涉及通式（Ia，1b，1c）的新型磺酰胺衍生物，其任选呈其立体异构体之一形式，优选对映异构体或非对映异构体，其外消旋体或其至少两种立体异构体的混合物的形式， 优选对映异构体或非对映体，以任何混合比例或其盐，优选相应的生理上可接受的盐或相应的溶剂合物; 其制备方法，其作为人和/或兽医治疗剂中的药物的应用，以及含有它们的药物组合物。
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16.发明申请Indol-5-yl sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators 审中-公开吲哚-5-基磺酰胺衍生物，它们的制备及其用途5-ht-6作为调节剂公开(公告)号：US20070032520A1
公开(公告)日：2007-02-08
申请号：US10566094
申请日：2004-07-29
Applicant: Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
Inventor： Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
IPC: A61K31/4745 , A61K31/454 , A61K31/405 , C07D455/02 , C07D403/02
CPC classification number: C04B35/632 , C07D209/08 , C07D401/12 , C07D409/12 , C07D417/12 , C07D513/04
Abstract: The present invention refers to new sulfonamide derivatives, of general formula (1a, 1b, 1c) optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.
Abstract translation: 本发明涉及通式（1a，1b，1c）的新磺酰胺衍生物，其任选为其立体异构体之一，优选对映异构体或非对映异构体，其外消旋体或其至少两种立体异构体的混合物形式， 优选对映体或非对映体，以任何混合比例，或其盐，优选相应的生理学上可接受的盐或相应的溶剂合物; 其制备方法，作为人和/或兽医治疗剂中的药物的应用，以及含有它们的药物组合物。
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17.发明申请SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY 有权用于预防和/或治疗由化疗或放射治疗引起的EMESIS的SIGMA配偶公开(公告)号：US20130109692A1
公开(公告)日：2013-05-02
申请号：US13698718
申请日：2011-05-20
IPC: A61K45/06 , A61K31/5377 , C07D231/22
CPC classification number: A61K45/06 , A61K31/337 , A61K31/4523 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K33/24 , C07D231/22 , A61K2300/00
Abstract: The invention refers to the use of a sigma ligand, preferably a sigma ligand of formula (I), to prevent or treat emesis induced by a chemotherapeutic agent or radioactivity, especially emesis induced by taxanes, vinca alkaloids or platin chemotherapeutic drugs.
Abstract translation: 本发明涉及使用Sigma配体，优选式（I）的Sigma配体来预防或治疗由化学治疗剂或放射性引起的呕吐，特别是由紫杉烷，长春花生物碱或铂化学治疗药引起的呕吐。
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18.发明授权Indol-7-YL sulfonamide derivatives, their preparation and their use in pharmaceutical compositions 失效Indol-7-YL磺酰胺衍生物，它们的制备及其在药物组合物中的应用公开(公告)号：US07414070B2
公开(公告)日：2008-08-19
申请号：US10566403
申请日：2004-07-29
Applicant: Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
Inventor： Ramon Merce Vidal , Xavier Codony Soler , Alberto Dordal Zueras
IPC: A01N43/38 , A61K31/405 , C07D209/04
CPC classification number: C07D409/12 , C07D209/08 , C07D513/04
Abstract: The present invention refers to new sulfonamide derivatives, of general formula (Ia, Ib, Ic), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salts, preferably the corresponding, physiologically acceptable salts, or corresponding solvates; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.
Abstract translation: 本发明涉及通式（Ia，Ib，Ic）的新型磺酰胺衍生物，任选呈其立体异构体之一形式，优选对映异构体或非对映异构体，其外消旋体或其至少两种立体异构体的混合物的形式 ，优选对映异构体或非对映体，以任何混合比例，或其盐，优选相应的生理学上可接受的盐或相应的溶剂合物; 其制备方法，作为人和/或兽医治疗剂中的药物的应用，以及含有它们的药物组合物。
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