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1.发明申请SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY 有权用于预防和/或治疗由化疗或放射治疗引起的EMESIS的SIGMA配偶公开(公告)号：US20130109692A1
公开(公告)日：2013-05-02
申请号：US13698718
申请日：2011-05-20
IPC分类号： A61K45/06 , A61K31/5377 , C07D231/22
CPC分类号： A61K45/06 , A61K31/337 , A61K31/4523 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K33/24 , C07D231/22 , A61K2300/00
摘要： The invention refers to the use of a sigma ligand, preferably a sigma ligand of formula (I), to prevent or treat emesis induced by a chemotherapeutic agent or radioactivity, especially emesis induced by taxanes, vinca alkaloids or platin chemotherapeutic drugs.
摘要翻译： 本发明涉及使用Sigma配体，优选式（I）的Sigma配体来预防或治疗由化学治疗剂或放射性引起的呕吐，特别是由紫杉烷，长春花生物碱或铂化学治疗药引起的呕吐。
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2.发明申请USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY 审中-公开使用化合物与SIGMA受体配体结合，用于治疗神经性疼痛发展作为化学疗法的后果公开(公告)号：US20110052723A1
公开(公告)日：2011-03-03
申请号：US12735824
申请日：2009-02-17
申请人： José Manuel Baeyens-Cabrera , Helmut H. Buschmann , José-Miguel Vela-Hernandez , Daniel Zamanillo-Castanedo , Francisco Rafael Nieto-López
发明人： José Manuel Baeyens-Cabrera , Helmut H. Buschmann , José-Miguel Vela-Hernandez , Daniel Zamanillo-Castanedo , Francisco Rafael Nieto-López
IPC分类号： A61K31/495 , A61K33/24 , A61P29/02 , A61P25/02 , A61P25/00
CPC分类号： A61K31/495 , A61K31/137 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/5415
摘要： The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy.
摘要翻译： 本发明涉及结合σ受体的化合物用于治疗或预防化学疗法引起的神经性疼痛的用途。
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3.发明申请SIGMA LIGANDS FOR USE IN THE PREVENTION AND/OR TREATMENT OF POST-OPERATIVE PAIN 有权用于预防和/或治疗术后疼痛的SIGMA配偶公开(公告)号：US20120302568A1
公开(公告)日：2012-11-29
申请号：US13574940
申请日：2011-02-04
IPC分类号： A61K31/5377 , A61P25/00
CPC分类号： A61K31/00 , A61K31/415 , A61K31/416 , A61K31/4196 , A61K31/5377
摘要： The invention refers to the use of a sigma ligand, particularly a sigma ligand of formulae (I), (II) or (III) to prevent and/or treat acute and chronic pain developed as a consequence of surgery, especially superficial and/or deep pain secondary to surgical tissue injury, and peripheral neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuritis or neuropathy secondary to surgical procedure.
摘要翻译： 本发明涉及Sigma配体，特别是式（I），（II）或（III）的Sigma配体用于预防和/或治疗由于手术而发展的急性和慢性疼痛，特别是表面和/或 手术组织损伤继发的深部疼痛，外周神经性疼痛，神经痛，异常性疼痛，灼痛，痛觉过敏，感觉过敏，低渗，神经炎或继发于外科手术的神经病变。
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公开(公告)号：US09757358B2
公开(公告)日：2017-09-12
申请号：US13574121
申请日：2011-02-04
IPC分类号： A61K31/4152 , A61K31/137 , A61K31/485 , A61K45/06
CPC分类号： A61K31/4152 , A61K31/137 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： The invention refers to a combination comprising a sigma ligand of formula (I) and an opioid or opiate for use in the prevention and/or treatment of pain developed as a consequence of surgery, especially peripheral neuropathic pain, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuralgia, neuritis or neuropathy. The invention also refers to the sigma ligands of formula (I) for use in potentiating the analgesic effect of an opioid or opiate and/or for decreasing the dependency induced thereby when said opioid or opiate is used in the prevention and/or treatment of pain developed as a consequence of surgery.
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5.发明申请Sigma Ligands For the Prevention or Treatment of Pain Induced by Chemotherapy 审中-公开Sigma配体用于预防或治疗化疗引起的疼痛公开(公告)号：US20160220575A1
公开(公告)日：2016-08-04
申请号：US15093589
申请日：2016-04-07
申请人： José Manuel Baeyens-Cabrera , Helmut Heinrich Buschmann , José Miguel Vela Hernández , Daniel Zamanillo-Castanedo , Francisco-Rafael Nieto-López
发明人： José Manuel Baeyens-Cabrera , Helmut Heinrich Buschmann , José Miguel Vela Hernández , Daniel Zamanillo-Castanedo , Francisco-Rafael Nieto-López
IPC分类号： A61K31/5377
CPC分类号： A61K31/5377 , A61K31/337 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention refers to the use of a sigma ligand of formula (I) to prevent or treat pain induced by a chemotherapeutic agent, especially pain induced by taxanes, vinca alkaloids or platinum-containing chemotherapeutic drugs.
摘要翻译： 本发明涉及使用式（I）的Sigma配体来预防或治疗由化学治疗剂诱导的疼痛，特别是由紫杉烷类，长春花生物碱或含铂化疗药引起的疼痛。
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公开(公告)号：US20160199380A1
公开(公告)日：2016-07-14
申请号：US15073460
申请日：2016-03-17
申请人： José Manuel Baeyens-Cabrera , Helmut Heinrich Buschmann , José Miguel Vela Hernández , Daniel Zamanillo-Castanedo , Francisco-Rafael Nieto-López
发明人： José Manuel Baeyens-Cabrera , Helmut Heinrich Buschmann , José Miguel Vela Hernández , Daniel Zamanillo-Castanedo , Francisco-Rafael Nieto-López
IPC分类号： A61K31/5377 , A61K31/337 , A61K33/24 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/337 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention refers to the use of a sigma ligand of formula (I) to prevent or treat pain induced by a chemotherapeutic agent, especially pain induced by taxanes, vinca alkaloids or platinum-containing chemotherapeutic drugs.
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7.发明申请1-ARYL-3-AMINOALKOXY PYRAZOLES AS SIGMA LIGANDS ENHANCING ANALGESIC EFFECT OF OPIOIDS AND ATTENUATING THE DEPENDENCY THEREOF 有权1-ARYL-3-AMINOALKOXY PYRAZOLES作为SIGMA配体，增强了光合作用的有效作用并使其丧失依赖性公开(公告)号：US20110112095A1
公开(公告)日：2011-05-12
申请号：US12988951
申请日：2009-04-24
IPC分类号： A61K31/5377 , A61K31/485 , A61P25/36
CPC分类号： C07D231/22 , A61K31/4152 , A61K31/4155 , A61K31/485 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D471/04 , A61K2300/00
摘要： The invention relates to the use of a group of sigma receptor ligands of formula (I) for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.
摘要翻译： 本发明涉及一组式（I）的σ受体配体用于增强阿片样物质和阿片剂的镇痛作用，同时降低它们引起的依赖性。
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8.发明授权1-aryl-3-aminoalkoxy pyrazoles as sigma ligands enhancing analgesic effect of opioids and attenuating the dependency thereof 有权1-芳基-3-氨基烷氧基吡唑作为西格玛配体增强阿片样物质的镇痛作用并减弱其依赖性公开(公告)号：US08877753B2
公开(公告)日：2014-11-04
申请号：US12988951
申请日：2009-04-24
IPC分类号： A61K31/4152 , A61K31/4155 , A61K31/485 , A61K31/5377 , A61P25/36 , C07D231/22 , C07D401/12 , C07D403/12 , C07D471/04 , A61K45/06
CPC分类号： C07D231/22 , A61K31/4152 , A61K31/4155 , A61K31/485 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D471/04 , A61K2300/00
摘要： The invention relates to the use of a group of sigma receptor ligands of formula (I) for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.
摘要翻译： 本发明涉及一组式（I）的σ受体配体用于增强阿片样物质和阿片剂的镇痛作用，同时降低它们引起的依赖性。
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公开(公告)号：US20130324535A1
公开(公告)日：2013-12-05
申请号：US13991282
申请日：2011-12-02
IPC分类号： C07D231/22 , A61K31/5377 , A61K31/485
摘要： The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat pain associated to bone cancer.
摘要翻译： 本发明涉及使用Sigma配体，特别是式（I）的Sigma配体来预防和/或治疗与骨癌相关的疼痛。
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公开(公告)号：US20130158033A1
公开(公告)日：2013-06-20
申请号：US13814148
申请日：2011-08-02
IPC分类号： A61K31/5377
CPC分类号： A61K31/5377 , A61K31/415 , A61K31/4155
摘要： The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat opioid-induced hyperalgesia (OIH) associated to opioid therapy.
摘要翻译： 本发明涉及使用Sigma配体，特别是式（I）的Sigma配体来预防和/或治疗与阿片类药物治疗相关的阿片样物质诱导的痛觉过敏（OIH）。
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