公开(公告)号：US10137222B2

公开(公告)日：2018-11-27

申请号：US15551517

申请日：2016-03-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jason W. Bjork ,  Alexi J Young ,  Raha A. Been ,  Jana Ninkovic ,  Bryan A. Baker

IPC: A61L26/00 ,  A61L24/10 ,  A61F13/02 ,  A61F13/00

Abstract: A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.