公开(公告)号：US20140287033A1

公开(公告)日：2014-09-25

申请号：US14299771

申请日：2014-06-09

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Deborah Kilpatrick ,  Syed Faiyaz Ahmed Hossainy ,  Irina Astafieva ,  Florian N. Ludwig ,  Paul M. Consigny ,  Jeffrey T. Ellis ,  Florencia Lim

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  A61K9/0019 ,  A61K9/1275 ,  A61K9/1617 ,  A61K9/1658 ,  A61M1/3472 ,  A61M1/3486 ,  A61M2202/0456 ,  A61K2300/00

Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.

Abstract translation: 一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。 包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。 包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。 一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

公开(公告)号：US20140178454A1

公开(公告)日：2014-06-26

申请号：US14109795

申请日：2013-12-17

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Florencia Lim ,  Mikael O. Trollsas ,  Syed F.A. Hossainy ,  Stephen D. Pacetti

IPC: A61L31/10 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/606 ,  Y10T24/258 ,  C08L67/04

Abstract: The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.

Abstract translation: 本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。