公开(公告)号：US09358268B2

公开(公告)日：2016-06-07

申请号：US14299771

申请日：2014-06-09

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Deborah Kilpatrick ,  Syed Faiyaz Ahmed Hossainy ,  Irina Astafieva ,  Florian N. Ludwig ,  Paul M. Consigny ,  Jeffrey T. Ellis ,  Florencia Lim

IPC: A61K38/17 ,  A61K9/00 ,  A61K9/127 ,  A61K9/16 ,  A61M1/34

CPC classification number: A61K38/1709 ,  A61K9/0019 ,  A61K9/1275 ,  A61K9/1617 ,  A61K9/1658 ,  A61M1/3472 ,  A61M1/3486 ,  A61M2202/0456 ,  A61K2300/00

Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.

Abstract translation: 一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。 包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。 包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。 一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

公开(公告)号：US20140287033A1

公开(公告)日：2014-09-25

申请号：US14299771

申请日：2014-06-09

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Deborah Kilpatrick ,  Syed Faiyaz Ahmed Hossainy ,  Irina Astafieva ,  Florian N. Ludwig ,  Paul M. Consigny ,  Jeffrey T. Ellis ,  Florencia Lim

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  A61K9/0019 ,  A61K9/1275 ,  A61K9/1617 ,  A61K9/1658 ,  A61M1/3472 ,  A61M1/3486 ,  A61M2202/0456 ,  A61K2300/00

Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.

Abstract translation: 一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。 包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。 包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。 一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。