公开(公告)号：US20240342091A1

公开(公告)日：2024-10-17

申请号：US18634454

申请日：2024-04-12

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Keith P. JOHNSTON ,  Joshua ENGSTROM ,  Robert O. WILLIAMS, III

IPC分类号： A61K9/16 ,  B01D9/00

CPC分类号： A61K9/1682 ,  A61K9/1658 ,  B01D9/005 ,  Y10T428/2982

摘要： The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.

公开(公告)号：US20240130971A1

公开(公告)日：2024-04-25

申请号：US18373749

申请日：2023-09-26

申请人： University of Mississippi Medical Center

发明人： Amol V. JANORKAR ,  Jared S. COBB ,  John J. CORREIA ,  Valeria ZAI-ROSE

IPC分类号： A61K9/16 ,  A61K45/06 ,  A61K47/69

CPC分类号： A61K9/1658 ,  A61K9/1641 ,  A61K9/1682 ,  A61K45/06 ,  A61K47/6927

摘要： This disclosure relates to macro- and micro-sized elastin-like polymers (ELP). The addition of a polyethyleneimine (PEI) block to the terminal end of ELP allows the particle radius as well as LCST to be controlled by changing any combination of polymer concentration, ion concentration, and pH. The addition of the PEI block also provides the ability to crosslink the copolymers and achieve a stable particle radius.

公开(公告)号：US20240075079A1

公开(公告)日：2024-03-07

申请号：US17955413

申请日：2022-09-28

申请人： Research Institute at Nationwide Children's Hospital ,  Ohio State Innovation Foundation

发明人： Steven D. Goodman ,  Lauren O. Bakaletz ,  Michael Bailey ,  Gail Besner

IPC分类号： A61K35/747 ,  A01N63/20 ,  A01N63/22 ,  A01N63/23 ,  A01N63/27 ,  A23L33/135 ,  A23L33/195 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K35/741 ,  A61K47/10 ,  A61K47/22

CPC分类号： A61K35/747 ,  A01N63/20 ,  A01N63/22 ,  A01N63/23 ,  A01N63/27 ,  A23L33/135 ,  A23L33/195 ,  A61K9/0031 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/50 ,  A61K35/741 ,  A61K47/10 ,  A61K47/22 ,  A23V2002/00 ,  A23V2200/3202 ,  A23V2200/3204

摘要： Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.

公开(公告)号：US11878036B2

公开(公告)日：2024-01-23

申请号：US18321644

申请日：2023-05-22

申请人： Neuvian LLC

发明人： Spencer Bouhadir ,  Jacob Miguel

IPC分类号： A61K35/32 ,  A61K35/12 ,  A61K35/35 ,  A61K35/407 ,  A61K35/42 ,  A61K35/50 ,  A61K35/51 ,  A61K9/00 ,  A61K9/16 ,  A61K9/48 ,  A61K31/4172 ,  A61K45/06 ,  A61K47/02 ,  A61P15/00 ,  A61P15/02

CPC分类号： A61K35/32 ,  A61K9/0034 ,  A61K9/1611 ,  A61K9/1658 ,  A61K9/1664 ,  A61K9/485 ,  A61K9/4833 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/4875 ,  A61K31/4172 ,  A61K35/12 ,  A61K35/35 ,  A61K35/407 ,  A61K35/42 ,  A61K35/50 ,  A61K35/51 ,  A61K45/06 ,  A61K47/02 ,  A61P15/00 ,  A61P15/02

摘要： The instant disclosure is directed to a vaginal care composition that restores pH balance, and thereby reduces vaginal dryness, irritation, dyspareunia, post-coital bleeding, infections, vaginal and pelvic pain and increases vaginal lubrication. In some embodiments, the vaginal care composition comprises stem cell-derived exosomes (e.g., mesenchymal stem cell (MSC)-derived exosomes), an antioxidant and a pH buffer. Another aspect of the disclosure is directed to methods for improving vaginal health by administering the vaginal care composition of the instant disclosure.

公开(公告)号：US11872205B2

公开(公告)日：2024-01-16

申请号：US18160036

申请日：2023-01-26

申请人： Mayo Foundation for Medical Education and Research

发明人： Gerald F. Swiss ,  Jesse Crowne ,  Svetomir N. Markovic ,  Wendy K. Nevala

IPC分类号： A61K31/337 ,  A61K47/68 ,  A61K47/69 ,  A61K47/64 ,  A61K47/54 ,  A61P35/00 ,  A61K9/16

CPC分类号： A61K31/337 ,  A61K9/1658 ,  A61K47/549 ,  A61K47/643 ,  A61K47/6803 ,  A61K47/6843 ,  A61K47/6845 ,  A61K47/6849 ,  A61K47/6865 ,  A61K47/6869 ,  A61K47/6891 ,  A61K47/6929 ,  A61P35/00

摘要： Described herein are methods, formulations and kits for treating a patient with triple-negative breast cancer with nanoparticle complexes comprising a carrier protein (e.g., albumin), paclitaxel and a binding agent specific for a target antigen expressed by the cells (e.g., an anti-VEGF antibody).

公开(公告)号：US20230413845A1

公开(公告)日：2023-12-28

申请号：US18340572

申请日：2023-06-23

申请人： 5071, Inc.

发明人： Jeremy H. GOLDSTEIN ,  Justin E. SINGER ,  Adrian VERWOLF ,  Garret NICODEMUS

IPC分类号： A23F3/14 ,  A61K9/16 ,  A23L33/105 ,  A61K9/00 ,  A61K31/352 ,  A23L33/115 ,  A61K31/05 ,  A23P10/40 ,  A23L2/52

CPC分类号： A23F3/14 ,  A61K9/1658 ,  A23L33/105 ,  A61K9/0095 ,  A61K9/1617 ,  A61K9/1623 ,  A61K31/352 ,  A61K9/1664 ,  A23L33/115 ,  A61K31/05 ,  A23P10/40 ,  A23L2/52 ,  A23V2002/00

摘要： Disclosed herein are new cannabis compositions. In one embodiment, these new cannabis compositions are beverages, such as tea. In one embodiment, these new cannabis compositions are dehydrated beverages, such as powders or crystalline forms, which can be mixed with other components, like tea, and added to water.

公开(公告)号：US20230390205A1

公开(公告)日：2023-12-07

申请号：US18451593

申请日：2023-08-17

申请人： Catalent U.K. Swindon Zydis Limited

发明人： Rosaleen MCLAUGHLIN ,  Simon Andrew Martyn HOWES ,  Craig WHEADON ,  Jonathon WHITEHOUSE

IPC分类号： A61K9/16

CPC分类号： A61K9/167 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1658

摘要： Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions using solventless mixing methods. Excess coating material that is not bound to a coated API particle may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Specifically, a coating ratio and/or a dosing ratio can be used to minimize the residual amount of excess unbound coating material to minimize agglomeration of coating material during storage. In some embodiments, a pharmaceutical composition is provided, the pharmaceutical composition comprising: 65-85% w/w API particles; 15-30% w/w coating material coating the API particles; and 3-15% w/w matrix surrounding the coated API particles, wherein the pharmaceutical composition comprises a disintegration time rate of less than 10 seconds for at least six months under storage conditions of at least 25° C. and at least 60% relative humidity.

公开(公告)号：US20230248653A1

公开(公告)日：2023-08-10

申请号：US18299997

申请日：2023-04-13

申请人： Cannabis Global, Inc.

发明人： Joseph Noel

IPC分类号： A61K9/16 ,  A61K31/047 ,  A61K31/352

CPC分类号： A61K9/1658 ,  A61K31/047 ,  A61K31/352

摘要： A composition comprising a plurality of discrete particles comprising one or more cannabinoids disposed at least partially within a polymeric carrier having a maximum overall dimension of less than 1 micron. A composition comprising a plurality of discrete nanofibers comprising one or more cannabinoids disposed at least partially within a polymeric carrier is also disclosed along with methods to produce the same.

公开(公告)号：US11654111B2

公开(公告)日：2023-05-23

申请号：US16722216

申请日：2019-12-20

申请人： GELPELL AG ,  SATIPHARM AG

发明人： Hagit Sacks ,  Tomas Edvinsson

IPC分类号： A61K31/05 ,  A61K45/06 ,  A61K9/16 ,  A61K36/185 ,  A61K31/352

CPC分类号： A61K9/1658 ,  A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  A61K45/06 ,  A61K31/05 ,  A61K2300/00 ,  A61K31/352 ,  A61K2300/00

摘要： Provided are solid oral/per os formulations that include a single cannabinoid, combination of cannabinoids, cannabis extract and combination of cannabis plant constituents. Also provided are methods of making the formulations, as well as therapeutic applications in the treatment and alleviation of various human disorders and/or conditions.

公开(公告)号：US20180264076A1

公开(公告)日：2018-09-20

申请号：US15986584

申请日：2018-05-22

申请人： Sigmoid Pharma Limited

发明人： Ivan Coulter ,  Bernard Francis McDonald ,  Vincenzo Aversa

IPC分类号： A61K38/13 ,  A61K47/44 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K9/16 ,  A61K31/436 ,  A61K9/50 ,  A61K38/00

CPC分类号： A61K38/13 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/5026 ,  A61K9/5036 ,  A61K9/5047 ,  A61K9/5073 ,  A61K31/436 ,  A61K38/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  Y02A50/465 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475

摘要： A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.