公开(公告)号：US09051327B2

公开(公告)日：2015-06-09

申请号：US14307680

申请日：2014-06-18

Applicant: AbbVie Inc.

Inventor： Gui-Dong Zhu ,  Jane Gong ,  Andrew S. Judd ,  Virajkumar B. Gandhi ,  Alexander R. Shoemaker ,  Thomas D. Penning ,  Michael R. Michaelides ,  Chunqiu Lai ,  Keith W. Woods

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/02 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。