公开(公告)号：US09163007B2

公开(公告)日：2015-10-20

申请号：US14136359

申请日：2013-12-20

Applicant: AbbVie Inc.

Inventor： Irini Akritopoulou-Zanze ,  Brian D. Wakefield ,  Helmut Mack ,  Sean C. Turner ,  Alan F. Gasiecki ,  Vijaya J. Gracias ,  Kathy A. Sarris ,  Douglas M. Kalvin ,  Melissa J. Michmerhuizen ,  Qi Shuai ,  Jyoti R. Patel ,  Margaretha H. M. Bakker ,  Nicole Teusch ,  Eric F. Johnson ,  Peter J. Kovar ,  Stevan W. Djuric ,  Andrew J. Long ,  Anil Vasudevan ,  Dawn M. George ,  Lu Wang ,  Biqin Li ,  Nigel S. Moore ,  Adrian D. Hobson ,  Keith W. Woods ,  Julie M. Miyashiro ,  Steven L. Swann, Jr. ,  Thomas D. Penning

IPC: C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04

CPC classification number: C07D413/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中A，R 1，R 2，R 3和m在说明书中定义。 本发明还涉及制备所述化合物的方法和含有所述化合物的组合物，其可用于抑制激酶例如糖原合成酶激酶3（GSK-3），Rho激酶（ROCK），Janus激酶（JAK），Cdc7，AKT ，PAK4，PLK，CK2，KDR，MK2，JNK1，极光，pim1和nek2。

公开(公告)号：US09051327B2

公开(公告)日：2015-06-09

申请号：US14307680

申请日：2014-06-18

Applicant: AbbVie Inc.

Inventor： Gui-Dong Zhu ,  Jane Gong ,  Andrew S. Judd ,  Virajkumar B. Gandhi ,  Alexander R. Shoemaker ,  Thomas D. Penning ,  Michael R. Michaelides ,  Chunqiu Lai ,  Keith W. Woods

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/02 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：US20140343066A1

公开(公告)日：2014-11-20

申请号：US14136359

申请日：2013-12-20

Applicant: AbbVie Inc.

Inventor： Irini Akritopoulou-Zanze ,  Brian D. Wakefield ,  Helmut Mack ,  Sean C. Turner ,  Alan F. Gasiecki ,  Vijaya J. Gracias ,  Kathy A. Sarris ,  Douglas M. Kalvin ,  Melissa J. Michmerhuizen ,  Qi Shuai ,  Jyoti R. Patel ,  Margaretha H.M. Bakker ,  Nicole Teusch ,  Eric F. Johnson ,  Peter J. Kovar ,  Stevan W. Djuric ,  Andrew J. Long ,  Anil Vasudevan ,  Dawn M. George ,  Lu Wang ,  Biqin Li ,  Nigel S. Moore ,  Adrian D. Hobson ,  Keith W. Woods ,  Julie M. Miyashiro ,  Steven L. Swann, Jr. ,  Thomas D. Penning

IPC: C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

CPC classification number: C07D413/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中A，R 1，R 2，R 3和m在说明书中定义。 本发明还涉及制备所述化合物的方法和含有所述化合物的组合物，其可用于抑制激酶例如糖原合成酶激酶3（GSK-3），Rho激酶（ROCK），Janus激酶（JAK），Cdc7，AKT ，PAK4，PLK，CK2，KDR，MK2，JNK1，极光，pim1和nek2。

公开(公告)号：US09650358B2

公开(公告)日：2017-05-16

申请号：US14207854

申请日：2014-03-13

Applicant: AbbVie Inc.

Inventor： Anthony Mastracchio ,  Milan Bruncko ,  Chunqiu Lai ,  Julie M. Miyashiro ,  Zhi-Fu Tao ,  Keith W. Woods ,  Thomas D. Penning ,  Andrew J. Souers

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/444 ,  A61K31/506 ,  A61K31/439

CPC classification number: C07D401/04 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

Abstract: Disclosed are compound of Formula (Ia), wherein R2, R12, R16, J, Q, X, Y and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (Ia).

公开(公告)号：US08969375B2

公开(公告)日：2015-03-03

申请号：US14207841

申请日：2014-03-13

Applicant: AbbVie Inc.

Inventor： Chunqiu Lai ,  Zhi-Fu Tao ,  Keith W. Woods ,  Thomas D. Penning ,  Andrew J. Souers ,  Anthony Mastracchio ,  Julie M. Miyashiro ,  Yunsong Tong

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

Abstract: Disclosed are compound of Formula (Ia), wherein R1A, R1, R2, R10, J, L, T, X, Y, and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions, comprising one or more compounds of Formula (Ia).

Abstract translation: 公开了式（Ia）的化合物，其中R 1A，R 1，R 2，R 10，J，L，T，X，Y和Z如说明书中所定义，及其药学上可接受的盐。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还提供了包含一种或多种式（Ia）化合物的药物组合物。

公开(公告)号：US20130225589A1

公开(公告)日：2013-08-29

申请号：US13773906

申请日：2013-02-22

Applicant: AbbVie Inc.

Inventor： Keith W. Woods ,  Anthony Mastracchio ,  Chunqiu Lai ,  Viraj B. Gandhi ,  Thomas D. Penning

IPC: C07D471/14 ,  C07D471/04

CPC classification number: C07D471/14 ,  A61K31/519 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1，R2，R3，R4和B在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：US09796708B2

公开(公告)日：2017-10-24

申请号：US14780018

申请日：2014-03-13

Applicant: AbbVie Inc.

Inventor： Yunsong Tong ,  Milan Bruncko ,  Richard F. Clark ,  Michael Curtin ,  Alan S. Florjancic ,  Robin R. Frey ,  Jianchun Gong ,  Todd M. Hansen ,  Zhiqin Ji ,  Chunqiu Lai ,  Anthony Mastracchio ,  Michael Michaelides ,  Juliem Miyashiro ,  Roberto M. Risi ,  Xiaohong Song ,  Zhi-fu Tao ,  Keith W. Woods ,  Guidong Zhu ,  Thomas Penning ,  Andrew Souers ,  Rajeev Goswami ,  Omprakash Reddy Iguturi ,  Madhu Babu Dabbeeru

IPC: C07D401/02 ,  C07D401/10 ,  A61K31/437 ,  A61K31/4353 ,  C07D471/04 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).

公开(公告)号：US20140357616A1

公开(公告)日：2014-12-04

申请号：US14444540

申请日：2014-07-28

Applicant: AbbVie Inc.

Inventor： Thomas D. Penning ,  Keith W. Woods ,  Chunqiu Lai ,  Alan S. Florjancic ,  Yunsong Tong

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：US20140296220A1

公开(公告)日：2014-10-02

申请号：US14307680

申请日：2014-06-18

Applicant: AbbVie Inc.

Inventor： Gui-Dong Zhu ,  Jane Gong ,  Andrew S. Judd ,  Virajkumar B. Ghandi ,  Alexander R. Shoemaker ,  Thomas D. Penning ,  Michael R. Michaelides ,  Chunqiu Lai ,  Keith W. Woods

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：US09718821B2

公开(公告)日：2017-08-01

申请号：US13773906

申请日：2013-02-22

Applicant: AbbVie Inc.

Inventor： Keith W. Woods ,  Anthony Mastracchio ,  Chunqiu Lai ,  Viraj B. Gandhi ,  Thomas D. Penning

IPC: A61K31/519 ,  C07D471/14 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D471/14 ,  A61K31/519 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.