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公开(公告)号：US20150218165A1
公开(公告)日：2015-08-06
申请号：US14568153
申请日：2014-12-12
Applicant: AbbVie Inc.
Inventor： Robin Frey , Jianchun Gong , Zhiqin JI , Chunqiu Lai , Thomas Penning , Xiaohong Song , Andrew Souers , Yunsong Tong , Gui-Dong Zhu
IPC: C07D471/16 , A61K31/437 , A61K31/55
CPC classification number: C07D471/16 , A61K31/437 , A61K31/55 , C07D498/16 , C07D519/00
Abstract: Disclosed are compounds of Formula (Ia), and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3A, R3B, and R4 are as described herein. The compounds may be used as agents in the treatment of diseases, including cancer. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (Ia).
Abstract translation: 公开了式（Ia）化合物及其药学上可接受的盐，其中X，Y，R 1，R 2，R 3A，R 3B和R 4如本文所述。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还公开了包含一种或多种式（Ia）化合物的药物组合物。
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![Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases](/abs-image/US/2015/06/09/US09051327B2/abs.jpg.150x150.jpg)
公开(公告)号：US09051327B2
公开(公告)日：2015-06-09
申请号：US14307680
申请日：2014-06-18
Applicant: AbbVie Inc.
Inventor： Gui-Dong Zhu , Jane Gong , Andrew S. Judd , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Michael R. Michaelides , Chunqiu Lai , Keith W. Woods
IPC: A01N43/90 , A61K31/519 , C07D487/02 , C07D487/04
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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3.发明申请1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 审中-公开在2位置上被苯基取代的苯并咪唑-4-羧酰胺是一种残留的PARP抑制剂公开(公告)号：US20140296235A1
公开(公告)日：2014-10-02
申请号：US14250698
申请日：2014-04-11
Applicant: AbbVie Inc.
Inventor： Thomas D. Penning , Sheela A. Thomas , Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Vincent L. Giranda
IPC: C07D401/14 , C07D401/10
CPC classification number: C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
Abstract: Compounds having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
Abstract translation: 具有式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含具有式（I）的化合物，包括具有式（I）的化合物的处理方法的药物组合物，以及包含具有式（I）的化合物的PARP酶的抑制方法。
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Patent Agency Ranking
公开(公告)号：US09283222B2
公开(公告)日：2016-03-15
申请号：US13902055
申请日：2013-05-24
Applicant: Abbvie Inc.
Inventor： Virajkumar B. Gandhi , Vincent L. Giranda , Jianchun Gong , Thomas D. Penning , Gui-Dong Zhu
IPC: A61K31/502 , C07D237/32 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , A61K31/551 , A61K45/06 , A61N5/10
CPC classification number: A61K31/502 , A61K31/551 , A61K45/06 , A61N5/10 , C07D237/32 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14
Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
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![PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES](/abs-image/US/2014/10/02/US20140296220A1/abs.jpg.150x150.jpg)
公开(公告)号：US20140296220A1
公开(公告)日：2014-10-02
申请号：US14307680
申请日：2014-06-18
Applicant: AbbVie Inc.
Inventor： Gui-Dong Zhu , Jane Gong , Andrew S. Judd , Virajkumar B. Ghandi , Alexander R. Shoemaker , Thomas D. Penning , Michael R. Michaelides , Chunqiu Lai , Keith W. Woods
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US09328112B2
公开(公告)日：2016-05-03
申请号：US14568153
申请日：2014-12-12
Applicant: AbbVie Inc.
Inventor： Robin Frey , Jane Gong , Zhiqin Ji , Chunqiu Lai , Thomas Penning , Xiaohong Song , Andrew Souers , Yunsong Tong , Gui-Dong Zhu
IPC: A61K31/437 , A61K31/55 , C07D471/16 , C07D498/16 , C07D519/00
CPC classification number: C07D471/16 , A61K31/437 , A61K31/55 , C07D498/16 , C07D519/00
Abstract: Disclosed are compounds of Formula (Ia), and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3A, R3B, and R4 are as described herein. The compounds may be used as agents in the treatment of diseases, including cancer. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (Ia).
Abstract translation: 公开了式（Ia）化合物及其药学上可接受的盐，其中X，Y，R 1，R 2，R 3A，R 3B和R 4如本文所述。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还公开了包含一种或多种式（Ia）化合物的药物组合物。
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公开(公告)号：US20140213610A1
公开(公告)日：2014-07-31
申请号：US14011374
申请日：2013-08-27
Applicant: AbbVie Inc.
Inventor： Thomas D. Penning , Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Vincent L. Giranda
IPC: C07D471/04
CPC classification number: C07D471/04 , A61K31/47 , A61K31/497 , A61K31/53 , A61K31/535 , C07D491/04 , C07D495/04
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
Abstract translation: 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20140212509A1
公开(公告)日：2014-07-31
申请号：US13902055
申请日：2013-05-24
Applicant: Abbvie Inc.
Inventor： Virajkumar B. Gandhi , Vincent L. Giranda , Jianchun Gong , Thomas D. Penning , Gui-Dong Zhu
IPC: C07D403/10 , A61N5/10 , A61K31/502 , A61K45/06 , C07D237/32 , A61K31/551
CPC classification number: A61K31/502 , A61K31/551 , A61K45/06 , A61N5/10 , C07D237/32 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14
Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
Abstract translation: 公开了聚（ADP-核糖）聚合酶的抑制剂，其制备方法和使用它们治疗患者的方法。
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