公开(公告)号：US09782476B2

公开(公告)日：2017-10-10

申请号：US14480521

申请日：2014-09-08

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Alice L. Yu ,  Kun-Hsien Lin ,  Tai-Na Wu

IPC: C07H15/18 ,  A61K39/39 ,  A61K31/7032 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K2039/55511 ,  A61K2039/57 ,  C07H15/18

Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

公开(公告)号：US20140371079A1

公开(公告)日：2014-12-18

申请号：US14458935

申请日：2014-08-13

Applicant: Academia Sinica

Inventor： John Yu ,  Alice L. Yu ,  H.C. Wu ,  I-Ju Chen ,  Sheng-hung Wang

IPC: G06F19/16

CPC classification number: G16B15/00 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/337 ,  A61K31/475 ,  A61K31/496 ,  A61K31/704 ,  A61K38/10 ,  A61K45/06 ,  A61K47/6911 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/1234 ,  C07K5/1024 ,  C07K7/08 ,  G01N2333/47 ,  G01N2500/04 ,  A61K2300/00

Abstract: Cancer-targeting peptides having a PX1LX2 motif, in which X1 is His or an amino acid residue with a hydrophobic side chain and X2 is Pro, Phe, or Trp. Also disclosed herein are conjugates containing the cancer-targeting peptides and uses thereof in cancer treatment and diagnosis.

Abstract translation: 具有PX1LX2基序的癌靶向肽，其中X1是His或具有疏水侧链的氨基酸残基，X2是Pro，Phe或Trp。 本文还公开了含有癌靶向肽的缀合物及其在癌症治疗和诊断中的用途。