公开(公告)号：US12098164B2

公开(公告)日：2024-09-24

申请号：US16663651

申请日：2019-10-25

申请人： CELLEMEDY CO., LTD

发明人： Jeewon Lee ,  Bo Ram Lee

IPC分类号： C07K14/005 ,  A61K9/51 ,  A61K33/242 ,  A61K38/00 ,  A61K38/38 ,  A61K49/00 ,  C07K16/18 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K9/5169 ,  A61K9/5184 ,  A61K33/242 ,  A61K38/38 ,  A61K49/0056 ,  A61K49/0093 ,  C07K16/18 ,  C12N7/00 ,  A61K38/00 ,  C07K2319/31 ,  C07K2319/735 ,  C12N2710/10032 ,  C12N2730/10122 ,  C12N2730/10123

摘要： The present invention relates to recombinant self-assembling protein nanoparticles presenting an albumin-binding peptide at the surface. For the recombinant self-assembling protein nanoparticles according to the present invention, an albumin-binding peptide can reduce the immunogenicity of the recombinant self-assembling protein nanoparticles because the albumin-binding peptide is presented at the surface, and thus binds to an albumin protein present in vivo, and the albumin-binding peptide can also provide the cancer delivery function of the recombinant self-assembling protein nanoparticles because the albumin-binding peptide binds to albumin around cancer. Simultaneously, the binding of the albumin-binding peptide to albumin can significantly increase the in vivo residence time of the recombinant self-assembling protein nanoparticles, thus increasing the potential for use in various medical applications.

公开(公告)号：US12048750B2

公开(公告)日：2024-07-30

申请号：US17888072

申请日：2022-08-15

申请人： Blaze Bioscience, Inc.

发明人： Stacey J. Hansen ,  Claudia Jochheim ,  Dennis M. Miller ,  Natalie Winblade Nairn ,  Julia E. Novak ,  Mark R. Stroud ,  Valorie R. Wiss ,  Kelly Byrnes-Blake ,  Scott Presnell

IPC分类号： A61K38/00 ,  A61B5/00 ,  A61B6/00 ,  A61B6/03 ,  A61B6/40 ,  A61K47/64 ,  A61K47/65 ,  A61K49/00 ,  A61K51/08 ,  A61P13/12 ,  A61P19/02 ,  C07K14/435 ,  C07K14/47 ,  C07K16/24 ,  A61B5/055 ,  A61B8/08

CPC分类号： A61K47/6415 ,  A61B5/0071 ,  A61B6/037 ,  A61B6/4057 ,  A61B6/481 ,  A61K47/65 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/08 ,  A61P13/12 ,  A61P19/02 ,  C07K14/43518 ,  C07K14/43522 ,  C07K14/4726 ,  C07K16/244 ,  C07K16/248 ,  A61B5/055 ,  A61B8/481 ,  A61B2505/05 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/50

摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

公开(公告)号：US12048732B2

公开(公告)日：2024-07-30

申请号：US16093508

申请日：2017-04-14

申请人： Blaze Bioscience, Inc.

发明人： Stacey J. Hansen ,  Julia E. Novak

IPC分类号： A61K38/17 ,  A61K9/00 ,  A61K31/337 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/555 ,  A61K31/704 ,  A61K33/243 ,  A61K47/64 ,  A61K49/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/435

CPC分类号： A61K38/1767 ,  A61K9/0019 ,  A61K31/337 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/555 ,  A61K31/704 ,  A61K33/243 ,  A61K47/6415 ,  A61K49/0032 ,  A61K49/0056 ,  A61P35/00 ,  C07K14/00 ,  C07K14/43522

摘要： Compositions and formulations comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to detectable agents or active agents. Methods of detecting and treating ductal carcinoma in situ breast cancer, invasive ductal carcinoma breast cancer, lobular carcinoma in situ, invasive lobular carcinoma, and triple-negative breast cancer with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells.

公开(公告)号：US12023389B2

公开(公告)日：2024-07-02

申请号：US18164612

申请日：2023-02-05

申请人： Sanford Burnham Prebys Medical Discovery Institute

发明人： Tambet Teesalu ,  Pablo Scodeller ,  Erkki Ruoslahti

IPC分类号： A61K49/00 ,  C07K7/06 ,  A61K38/00

CPC分类号： A61K49/0093 ,  A61K49/0041 ,  A61K49/0056 ,  C07K7/06 ,  A61K38/00

摘要： Described herein are peptides, compositions, and methods for diagnosing, detecting, imaging, monitoring, preventing, treating, or ameliorating diseases or disorders including cancer, inflammatory disorder, and autoimmune disease.

公开(公告)号：US20240207421A1

公开(公告)日：2024-06-27

申请号：US18254565

申请日：2021-12-03

申请人： ALUME BIOSCIENCES, INC.

发明人： Michael WHITNEY ,  Quyen NGUYEN

IPC分类号： A61K47/64 ,  A61K41/00 ,  A61K49/00 ,  C12N15/10

CPC分类号： A61K47/64 ,  A61K41/0061 ,  A61K41/0071 ,  A61K41/0076 ,  A61K41/008 ,  A61K49/0056 ,  C12N15/1037

摘要： The present disclosure provides nerve targeting peptides, including those comprising the amino acid sequence of any one of SEQ ID NOS: 1-710; conjugates comprising such nerve targeting peptides and a cargo molecule; compositions comprising said peptides and conjugates; and methods of said peptides and conjugates in surgical procedures and other applications.

公开(公告)号：US20240181089A1

公开(公告)日：2024-06-06

申请号：US18282094

申请日：2022-03-16

申请人： XYLONIX PTE. LTD

发明人： Jinhyuk Fred Chung

IPC分类号： A61K49/00 ,  A61K47/64 ,  A61P35/00

CPC分类号： A61K49/0056 ,  A61K47/641 ,  A61K49/0032 ,  A61P35/00

摘要： The present invention relates to compositions for the intracellular delivery of therapeutically, active divalent metal ions, the compositions comprising a polypeptide having (i) one or more targeting moiety conjugated thereto, (ii) an ionophore conjugated thereto via a cleavable linker, and (iii) a divalent metal ion bound thereto, and methods for preparing such compositions, and their use in therapeutic methods.

公开(公告)号：US20240158444A1

公开(公告)日：2024-05-16

申请号：US18345506

申请日：2023-06-30

申请人： BicycleRD Limited

发明人： Gavin BENNETT ,  Daniel Paul TEUFEL

IPC分类号： C07K7/56 ,  A61K49/00 ,  A61K51/08 ,  C07K7/08 ,  C07K14/00

CPC分类号： C07K7/56 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/088 ,  C07K7/08 ,  C07K14/001

摘要： The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：US20240156998A1

公开(公告)日：2024-05-16

申请号：US18353822

申请日：2023-07-17

申请人： MEMORIAL SLOAN KETTERING CANCER CENTER ,  UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES ,  PHLIP, INC.

发明人： Jason S. Lewis ,  Dustin DEMOIN ,  Yana K. RESHETNYAK ,  Oleg A. ANDREEV ,  Nerissa VIOLA-VILLEGAS

IPC分类号： A61K51/08 ,  A61K47/54 ,  A61K47/64 ,  A61K49/00 ,  A61K49/08 ,  A61K49/12

CPC分类号： A61K51/088 ,  A61K47/545 ,  A61K47/547 ,  A61K47/64 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/124

摘要： The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.

公开(公告)号：US20240148912A1

公开(公告)日：2024-05-09

申请号：US18361516

申请日：2023-07-28

申请人： The Regents of the University of California

发明人： Michael Page ,  Charles S. Craik

IPC分类号： A61K49/00 ,  A61K47/64 ,  A61K47/65 ,  C07K7/08 ,  C08L89/00

CPC分类号： A61K49/0056 ,  A61K47/64 ,  A61K47/65 ,  A61K49/0032 ,  A61K49/0054 ,  C07K7/08 ,  C08L89/00 ,  C07K2319/00 ,  C07K2319/50 ,  C12N2501/385

摘要： The present disclosure provides activatable and detectable membrane-interacting peptides that, following activation, can interact with phospholipid bilayers, such as cell membranes. The present disclosure also provides methods of use of such compounds. The compounds of the present disclosure are of the general structure X1a-A-X2-Z-X1b, where A is a membrane-interacting peptide region having a plurality of nonpolar hydrophobic amino acid residues that, following separation from portions Z, is capable of interaction with a phospholipid bilayer; Z is an inhibitory peptide region that can inhibit the activity of portion A; X2 is a cleavable linker that can be cleaved to release cleavage products from the compound; and X1a and X1b are optionally-present chemical handles that facilitate conjugation of various cargo moieties to the compound. Prior to cleavage of the composition at X2, the composition acts as a promolecule that does not associate with cellular membranes to a significant or detectable level. Following cleavage at cleavable linker X2, the cleavage product including portion A is free to interact with a phospholipid bilayer (e.g., a cell membrane), and thus accumulate at a site associated with a cleavage-promoting environment. Detection of the membrane-associated cleavage product can be accomplished by detection of a moiety attached through X1a and/or X1b. Such compositions can be used in a variety of methods, including, for example, use in directly imaging active clotting within a subject.

公开(公告)号：US20240124523A1

公开(公告)日：2024-04-18

申请号：US18458690

申请日：2023-08-30

申请人： The Regents of the University of California

发明人： Quyen T. Nguyen ,  Mike Whitney ,  Dina Hingorani ,  Roger Y. Tsien ,  Stephen Adams

IPC分类号： C07K7/08 ,  A61K9/00 ,  A61K41/00 ,  A61K47/64 ,  A61K49/00 ,  C07K7/00 ,  G01N33/50

CPC分类号： C07K7/08 ,  A61K9/0014 ,  A61K9/0019 ,  A61K41/0057 ,  A61K47/64 ,  A61K49/0056 ,  C07K7/00 ,  G01N33/5005 ,  A61K45/06

摘要： The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention further provides human neuron or nerve targeting molecules comprising fluorescently-labeled peptides that specifically bind to human neurons or human nerves and compositions thereof.