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    PRODRUGS AND COMPOSITIONS FOR OPHTHALMOLOGY APPLICATIONS
    16.
    发明公开
    PRODRUGS AND COMPOSITIONS FOR OPHTHALMOLOGY APPLICATIONS 审中-公开

    公开(公告)号：US20240166691A1

    公开(公告)日：2024-05-23

    申请号：US18503390

    申请日：2023-11-07

    Applicant: Alcon Inc.

    Inventor： Howard Allen Ketelson ,  Rekha Rangarajan

    IPC: C07K7/64

    CPC classification number: C07K7/645

    Abstract: The present disclosure is directed to prodrugs, compositions including prodrugs, and methods for administering prodrugs and compositions thereof to a patient, including prodrugs represented by Formula (I):




    wherein: D is a drug moiety; Q is an oxygen atom, a sulfur atom, or a nitrogen atom; X is a chemical bond or




    each of G, G′, and G″ is independently an oxygen atom or a sulfur atom; L is a polyether; T is a hydrogen atom, a hydroxyl group, a thiol group, a boronic acid group, or an amine group; R1 is selected from the group consisting of a substituted aryl group, unsubstituted aryl group, and a substituted carbonyl group; and each of R2, R3, R1′, R2′, R3′, and R4′ is independently a hydrogen atom, a substituted C1-C20 alkyl group, or an unsubstituted C1 -C20 alkyl group. In at least one embodiment, a composition comprises a compound and a carrier material.

    DISSOLVABLE MEDICAL DEVICE AND KIT FOR CORNEAL SURFACE PROTECTION
    18.
    发明公开
    DISSOLVABLE MEDICAL DEVICE AND KIT FOR CORNEAL SURFACE PROTECTION 审中-公开

    公开(公告)号：US20230201112A1

    公开(公告)日：2023-06-29

    申请号：US18145256

    申请日：2022-12-22

    Applicant: Alcon Inc.

    Inventor： Howard Allen Ketelson ,  Rekha Rangarajan ,  Patrick John Sadd

    IPC: A61K9/00 ,  A61K9/70 ,  A61K47/36 ,  A61K47/32 ,  A61K47/10

    CPC classification number: A61K9/0051 ,  A61K9/70 ,  A61K47/36 ,  A61K47/32 ,  A61K47/10

    Abstract: A dissolvable medical device for protecting a corneal surface and providing lubrication and hydration to the corneal surface during ophthalmic surgery comprising: a polymeric film has sufficient dimensions to substantially cover a cornea when applied to an eye, wherein the polymeric film comprising one or more mucoadhesive polymers. The polymeric film dissolves between 15 minutes to 120 minutes to release the mucoadhesive polymers after applying the polymeric film to the eye and the polymeric film provides more effective corneal surface protection relative to a saline treatment based on Mean Green Fluorescence Index test (demonstrates corneal damage) during a simulated surgery. In addition, a kit for use in ophthalmic surgical procedures comprises 1) the at least one dissolvable medical device and 2) at least one viscosurgical viscoelastic or at least one ophthalmoscopic surgical contact lens.

    Ophthalmic emulsion
    19.
    发明授权
    Ophthalmic emulsion 有权

    公开(公告)号：US11234929B2

    公开(公告)日：2022-02-01

    申请号：US16811461

    申请日：2020-03-06

    Applicant: Alcon Inc.

    Inventor： Howard Allen Ketelson ,  David L. Meadows

    IPC: A61K9/107 ,  B01F17/00 ,  A61K9/00

    Abstract: The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.

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