公开(公告)号：US11730699B2

公开(公告)日：2023-08-22

申请号：US17147007

申请日：2021-01-12

Applicant: Alcon Inc.

Inventor： Howard Allen Ketelson ,  James W. Davis ,  Rekha Rangarajan

IPC: A61K31/736 ,  A61P27/02 ,  A61K9/00 ,  A61K9/107 ,  A61K47/14 ,  A61K47/24 ,  B01F17/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  B82Y5/00

CPC classification number: A61K9/1075 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  B82Y5/00

Abstract: The present invention is directed to a lipid-based ophthalmic emulsion. The emulsion has an increased amount of a mucoadhesive galactomannan polymer that promotes a long-lasting protection against desiccation and moisture retention.

公开(公告)号：US11672820B2

公开(公告)日：2023-06-13

申请号：US17664143

申请日：2022-05-19

Applicant: Alcon Inc.

Inventor： James W. Davis ,  Howard Allen Ketelson ,  Elaine E. Campbell ,  David L. Meadows ,  Rekha Rangarajan

IPC: A61K31/736 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/32 ,  A61K31/728

CPC classification number: A61K31/736 ,  A61K9/0048 ,  A61K31/728 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36

Abstract: The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.

公开(公告)号：US20220273699A1

公开(公告)日：2022-09-01

申请号：US17664143

申请日：2022-05-19

Applicant: Alcon Inc.

Inventor： James W. Davis ,  Howard Allen Ketelson ,  Elaine E. Campbell ,  David L. Meadows ,  Rekha Rangarajan

IPC: A61K31/736 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/32 ,  A61K31/728

Abstract: The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.

公开(公告)号：US20210060056A1

公开(公告)日：2021-03-04

申请号：US17060343

申请日：2020-10-01

Applicant: Alcon Inc.

Inventor： James W. Davis ,  Howard Allen Ketelson ,  Elaine E. Campbell ,  David L. Meadows ,  Rekha Rangarajan

IPC: A61K31/736 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/32 ,  A61K31/728

Abstract: The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the to compositions also comprise a borate compound.

公开(公告)号：US11376275B2

公开(公告)日：2022-07-05

申请号：US17060343

申请日：2020-10-01

Applicant: Alcon Inc.

Inventor： James W. Davis ,  Howard Allen Ketelson ,  Elaine E. Campbell ,  David L. Meadows ,  Rekha Rangarajan

IPC: A61K31/736 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/32 ,  A61K31/728

Abstract: The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the to compositions also comprise a borate compound.

公开(公告)号：US20230285443A1

公开(公告)日：2023-09-14

申请号：US18319196

申请日：2023-05-17

Applicant: Alcon Inc.

Inventor： James W. Davis ,  Howard Allen Ketelson ,  Elaine E. Campbell ,  David L. Meadows ,  Rekha Rangarajan

IPC: A61K31/736 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/32 ,  A61K31/728

CPC classification number: A61K31/736 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/32 ,  A61K31/728

Abstract: The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery, In one embodiment of the present invention; the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.

公开(公告)号：US20210128468A1

公开(公告)日：2021-05-06

申请号：US17147007

申请日：2021-01-12

Applicant: Alcon Inc.

Inventor： Howard Allen Ketelson ,  James W. Davis ,  Rekha Rangarajan

IPC: A61K9/107 ,  A61K47/02 ,  A61K47/24 ,  A61K47/36 ,  A61K9/00 ,  A61K47/26 ,  A61K47/34

Abstract: The present invention is directed to a lipid-based ophthalmic emulsion. The emulsion has an increased amount of a mucoadhesive galactomannan polymer that promotes a long-lasting protection against desiccation and moisture retention.