公开(公告)号：US10317391B2

公开(公告)日：2019-06-11

申请号：US15173809

申请日：2016-06-06

Applicant: Axion BioSystems, Inc.

Inventor： Isaac Perry Clements ,  Amanda Jervis Preyer ,  Swaminathan Rajaraman ,  Daniel Christopher Millard ,  James David Ross

IPC: G01N21/64 ,  G01N33/483 ,  G01N21/01 ,  G01N21/75 ,  B01L3/00 ,  G01N21/03

Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.

公开(公告)号：US09983198B2

公开(公告)日：2018-05-29

申请号：US15076223

申请日：2016-03-21

Applicant: Axion BioSystems, Inc.

Inventor： Stacie Ann Chvatal ,  Daniel Christopher Millard ,  James David Ross

IPC: G01N33/50 ,  H04L29/08 ,  A61B5/04 ,  A61B5/0464

CPC classification number: G01N33/5044 ,  A61B5/04 ,  A61B5/0464 ,  G01N33/5058 ,  G01N33/5061 ,  G01N33/5091 ,  G01N2800/326 ,  H04L67/12

Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.

公开(公告)号：US20160161465A1

公开(公告)日：2016-06-09

申请号：US15041589

申请日：2016-02-11

Applicant: Axion BioSystems, Inc.

Inventor： Isaac Perry Clements ,  Amanda Jervis Preyer ,  Swaminathan Rajaraman ,  Daniel Christopher Millard ,  James David Ross

IPC: G01N33/483 ,  G01N21/01

CPC classification number: G01N33/4836 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/01 ,  G01N21/75 ,  G01N2021/015 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/062

Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.