公开(公告)号：US20160052929A1

公开(公告)日：2016-02-25

申请号：US14853871

申请日：2015-09-14

Applicant: AbbVie Inc.

Inventor： William H. Bunnelle ,  Marc Scanio ,  Jason T. Brewer ,  Ying Wang ,  Irini Akritopoulou-Zanze

IPC: C07D487/04 ,  C07D487/14

CPC classification number: C07D487/04 ,  C07D487/14

Abstract: The present application relates to benzodiazepine and pyridodiazepine derivatives of formula (I) wherein R1, R2, R3, R4, X1, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I）的苯并二氮杂和吡啶并二氮杂衍生物，其中R 1，R 2，R 3，R 4，X 1，Y 1，Y 2和Y 3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

公开(公告)号：US20140275086A1

公开(公告)日：2014-09-18

申请号：US14215533

申请日：2014-03-17

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Wilhelm Amberg ,  Frauke Pohlki ,  Udo Lange ,  Ying X. Wang ,  Hongyu H. Zhao ,  Huan-Qiu Li ,  Jason T. Brewer ,  Irini Zanze ,  Justin Dietrich ,  Anil Vasudevan ,  Stevan W. Djuric ,  Yanbin Lao ,  Charles W. Hutchins

IPC: C07D207/09 ,  C07D401/12 ,  C07D207/48 ,  C07D401/14 ,  C07D403/14 ,  C07D487/04 ,  C07D487/10 ,  C07D417/14 ,  C07D409/14 ,  C07D495/04 ,  C07D471/04 ,  C07D403/12 ,  C07D405/14

CPC classification number: C07D207/09 ,  A61K31/4025 ,  A61K31/44 ,  C07D207/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D495/04

Abstract: The present invention relates to pyrrolidine derivatives of the formula (I), or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.