公开(公告)号：US20190048007A1

公开(公告)日：2019-02-14

申请号：US16003600

申请日：2018-06-08

申请人： AbbVie Deutschland GmbH & Co. KG

发明人： Hannes Koolman ,  Wilfried Braje ,  Helmut Mack ,  Andreas Haupt ,  Ana Lucia Relo ,  Karla Drescher ,  Margaretha Henrica Maria Bakker ,  Viktor Lakics ,  Carolin Hoft

IPC分类号： C07D471/06 ,  C07D487/06

摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.

公开(公告)号：US09540376B2

公开(公告)日：2017-01-10

申请号：US14657916

申请日：2015-03-13

申请人： AbbVie Deutschland GmbH & Co. KG

发明人： Gisela Backfisch ,  Margaretha Henrica Maria Bakker ,  Günter Blaich ,  Wilfried Braje ,  Karla Drescher ,  Thomas Erhard ,  Andreas Haupt ,  Viktor Lakics ,  Anna Linsenmeier ,  Helmut Mack ,  Raimund Peter ,  Ana Lucia Relo ,  Lynette Smyth

IPC分类号： A61K31/4353 ,  C07D471/06 ,  C07D471/18 ,  C07D471/04

CPC分类号： A61K31/5513 ,  C07D471/04 ,  C07D471/18

摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines, such as compounds of formula (I), carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.

摘要翻译： 本发明涉及携带取代烷基的三环六氢二氮杂喹啉，其制备方法，含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用途 制备用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的药物，用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的方法，以及制备这种化合物的方法 和组合物。