公开(公告)号：US5153203A

公开(公告)日：1992-10-06

申请号：US501720

申请日：1990-03-30

申请人： Takashi Yatsunami ,  Hitodshi Yamamoto ,  Yasuhiro Kuramoto ,  Norihiro Hayashi ,  Akira Yazaki ,  Satoshi Inoue ,  Shuichiro Noda ,  Hirotaka Amano

发明人： Takashi Yatsunami ,  Hitodshi Yamamoto ,  Yasuhiro Kuramoto ,  Norihiro Hayashi ,  Akira Yazaki ,  Satoshi Inoue ,  Shuichiro Noda ,  Hirotaka Amano

IPC分类号： C07D401/12 ,  C07D413/04 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D498/06

CPC分类号： C07D401/12 ,  C07D413/04 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  Y02P20/55

摘要： Antibacterial quinolone derivatives represented by the following formula and salts thereof are disclosed. ##STR1## wherein R.sup.1 meawns a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted phenyl group, R.sup.2 denotes a hydrogen atom or a carboxyl-protecting group, R.sup.3 represents a hydrogen or halogen atom or an amino, mono- or di-(lower alkyl)amino, hydroxyl or lower alkoxyl group, X is a hydrogen or halogen atom, Y means a nitrogen atom or a group C-R.sup.4 in which R.sup.4 is a hydrogen or halogen atom or a lower alkyl or lower alkoxyl group or is a group ##STR2## which forms a ring together with R.sup.1 (i.e., the asterisked carbon atoms are linked to the N(1) atom of the quinolone skeleton), and A denotes a specific N-containing group. Preparation processes of the quinolone derivatives and antibacterial agents containing the same are also disclosed.

公开(公告)号：US5399553A

公开(公告)日：1995-03-21

申请号：US076938

申请日：1993-06-16

申请人： Masaharu Yokomoto ,  Akira Yazaki ,  Norihiro Hayashi ,  Shunso Hatono ,  Satoshi Inoue ,  Yasuhiro Kuramoto

发明人： Masaharu Yokomoto ,  Akira Yazaki ,  Norihiro Hayashi ,  Shunso Hatono ,  Satoshi Inoue ,  Yasuhiro Kuramoto

IPC分类号： C07D471/06 ,  C07D519/00 ,  A61K37/02 ,  A61K31/50 ,  A61K31/55

CPC分类号： C07D471/06

摘要： A tricyclic compound represented by the general formula (1) and salts thereof are disclosed. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are also disclosed.

摘要翻译： 公开了由通式（1）表示的三环化合物及其盐。 （1）还公开了一种制备三环化合物及其盐的方法，以及含有三环化合物及其盐作为活性成分的抗微生物剂。

公开(公告)号：US5254685A

公开(公告)日：1993-10-19

申请号：US741333

申请日：1991-08-07

申请人： Masaharu Yokomoto ,  Akira Yazaki ,  Norihiro Hayashi ,  Shunso Hatono ,  Satoshi Inoue ,  Yasuhiro Kuramoto

发明人： Masaharu Yokomoto ,  Akira Yazaki ,  Norihiro Hayashi ,  Shunso Hatono ,  Satoshi Inoue ,  Yasuhiro Kuramoto

IPC分类号： C07D471/06 ,  C07D519/00 ,  A61K31/435 ,  A61K31/50 ,  A61K31/55

CPC分类号： C07D471/06

摘要： A tricyclic compound represented by the general formula (1) and salts thereof. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are also disclosed.

公开(公告)号：US08808693B2

公开(公告)日：2014-08-19

申请号：US13262196

申请日：2010-04-01

申请人： Christopher J. Ong ,  Martin E. Gleave ,  Norihiro Hayashi ,  James Peacock

发明人： Christopher J. Ong ,  Martin E. Gleave ,  Norihiro Hayashi ,  James Peacock

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K31/167 ,  A61K31/713 ,  A61K33/30 ,  A61K38/09 ,  A61K38/1709 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07K14/4703 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/61 ,  C12N15/113 ,  C12N2310/11 ,  A61K2300/00

摘要： Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

摘要翻译： 提供了用足以引起前列腺癌细胞的细胞死亡或抑制前列腺癌细胞增殖的生物有效量的用SEMA3C抑制剂治疗前列腺癌的方法，用途和药物组合物。 前列腺癌可以是雄激素受体（AR）阳性前列腺癌，SEMA3C抑制剂可以选自以下一种或多种：抗体，SEMA3C肽，反义RNA，siRNA，shRNA或小分子。

公开(公告)号：US20130028896A1

公开(公告)日：2013-01-31

申请号：US13262196

申请日：2010-04-01

申请人： Christopher J. Ong ,  Martin E. Gleave ,  Norihiro Hayashi ,  James Peacock

发明人： Christopher J. Ong ,  Martin E. Gleave ,  Norihiro Hayashi ,  James Peacock

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K31/16 ,  A61K38/00 ,  A61K31/713

CPC分类号： C07K16/22 ,  A61K31/167 ,  A61K31/713 ,  A61K33/30 ,  A61K38/09 ,  A61K38/1709 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07K14/4703 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/61 ,  C12N15/113 ,  C12N2310/11 ,  A61K2300/00

摘要： Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

公开(公告)号：US20110132328A1

公开(公告)日：2011-06-09

申请号：US12632175

申请日：2009-12-07

申请人： William E. Attwood ,  Norihiro Hayashi

发明人： William E. Attwood ,  Norihiro Hayashi

IPC分类号： F02M69/46 ,  F02M37/04

CPC分类号： F02M37/106 ,  F02M37/0023 ,  F02M37/0052 ,  F02M37/0082 ,  F02M37/0094

摘要： A vehicle fuel system may employ a fuel pump module with a reservoir within a fuel tank. The system may also employ a fuel injection common rail, a fuel supply line leading from the fuel pump module reservoir to the fuel injection common rail, and a fuel return line leading from the fuel injection common rail through a fuel pump module flange. Additionally, the system may employ a first return fuel check valve to release fuel only into a reservoir jet pump and/or a transfer jet pump, while a second return fuel check valve may release fuel only directly into the fuel pump module reservoir. An electric fuel pump within the reservoir may have a fuel pump check valve and supply fuel only to the reservoir jet pump and/or the transfer jet pump, and not to an engine, when activated by a pressure sensor in the fuel return line.

摘要翻译： 车辆燃料系统可以使用具有在燃料箱内的储存器的燃料泵模块。 该系统还可以使用燃料喷射共轨，从燃料泵模块储存器引导到燃料喷射共轨的燃料供应管线和从燃料喷射共轨通过燃料泵模块凸缘的燃料返回管线。 另外，该系统可以采用第一返回燃料止回阀来将燃料仅释放到储存器喷射泵和/或转移喷射泵中，而第二返回燃料止回阀可以仅将燃料直接释放到燃料泵模块储存器中。 储存器内的电动燃料泵可以具有燃料泵止回阀，并且仅当燃料返回管线中的压力传感器启动时才向燃料喷射泵和/或转移喷射泵供给燃料，而不向发动机供应燃料。

公开(公告)号：US20090241912A1

公开(公告)日：2009-10-01

申请号：US12382397

申请日：2009-03-16

申请人： Shin Iwaoka ,  Norihiro Hayashi ,  Masakazu Suzuki

发明人： Shin Iwaoka ,  Norihiro Hayashi ,  Masakazu Suzuki

IPC分类号： F02M37/04

CPC分类号： F02M37/0017 ,  Y10T137/86131

摘要： A fuel supply system includes a plurality of fuel pumps, and one suction filter. The suction filter includes connection portions that are connected to pump inlets of the fuel pumps, and an interval adjusting member that adjusts the interval between the connection portions in accordance with the interval between the fuel pumps. Thus, it is possible to fit the suction filter to the fuel pumps without changing the interval between the fuel pumps. Because the interval between pump outlets is not changed, it is possible to minimize the problems that are likely to occur when the suction filter is fitted to the fuel pumps.

摘要翻译： 燃料供给系统包括多个燃料泵和一个吸入过滤器。 吸入过滤器包括连接到燃料泵的泵入口的连接部分，以及间隔调节部件，其根据燃料泵之间的间隔来调节连接部分之间的间隔。 因此，可以将抽吸过滤器装配到燃料泵上而不改变燃料泵之间的间隔。 因为泵出口之间的间隔没有改变，所以可以将吸入过滤器安装到燃油泵时可能发生的问题最小化。

公开(公告)号：US07159574B2

公开(公告)日：2007-01-09

申请号：US11041984

申请日：2005-01-26

申请人： Norihiro Hayashi ,  Tetsuro Okazono

发明人： Norihiro Hayashi ,  Tetsuro Okazono

IPC分类号： F02M37/04

CPC分类号： F02M37/106 ,  F02M37/025 ,  Y10T137/86187 ,  Y10T137/86212

摘要： A fuel feed apparatus includes a sub-tank and a fuel pump that are received in the fuel tank. The sub-tank has an inner space that is partitioned into at least a first chamber and a second chamber. The fuel pump is arranged in the first chamber to discharge fuel received in the sub-tank to the outside of the fuel tank. The second chamber has an opening, through which the second chamber communicates with the outside of the sub-tank such that fuel accumulated in the second chamber is exhausted to the outside of the sub-tank through the opening. The fuel tank has a first tank space and a second tank space. The sub-tank is received in the first tank space. A first jet pump is disposed in the second chamber of the sub-tank. The first jet pump draws fuel accumulated in the second tank space into the first tank space.

摘要翻译： 燃料供给装置包括容纳在燃料箱中的副罐和燃料泵。 副容器具有至少分隔成第一室和第二室的内部空间。 燃料泵布置在第一室中以将容纳在副罐中的燃料排放到燃料箱的外部。 第二室具有开口，第二室通过该开口与副罐的外部连通，使得积聚在第二室中的燃料通过开口排出到副罐的外部。 燃料箱具有第一储罐空间和第二储罐空间。 副坦克被接收在第一个坦克空间。 第一喷射泵设置在副罐的第二室中。 第一喷射泵将在第二罐空间中积聚的燃料吸入第一罐空间。

公开(公告)号：US08820298B2

公开(公告)日：2014-09-02

申请号：US12632175

申请日：2009-12-07

申请人： William E. Attwood ,  Norihiro Hayashi

发明人： William E. Attwood ,  Norihiro Hayashi

IPC分类号： F02M37/04 ,  F02M69/46 ,  F02M37/10 ,  F02M37/00

CPC分类号： F02M37/106 ,  F02M37/0023 ,  F02M37/0052 ,  F02M37/0082 ,  F02M37/0094

摘要： A vehicle fuel system may employ a fuel pump module with a reservoir within a fuel tank. The system may also employ a fuel injection common rail, a fuel supply line leading from the fuel pump module reservoir to the fuel injection common rail, and a fuel return line leading from the fuel injection common rail through a fuel pump module flange. Additionally, the system may employ a first return fuel check valve to release fuel only into a reservoir jet pump and/or a transfer jet pump, while a second return fuel check valve may release fuel only directly into the fuel pump module reservoir. An electric fuel pump within the reservoir may have a fuel pump check valve and supply fuel only to the reservoir jet pump and/or the transfer jet pump, and not to an engine, when activated by a pressure sensor in the fuel return line.

摘要翻译： 车辆燃料系统可以使用具有在燃料箱内的储存器的燃料泵模块。 该系统还可以使用燃料喷射共轨，从燃料泵模块储存器引导到燃料喷射共轨的燃料供应管线和从燃料喷射共轨通过燃料泵模块凸缘的燃料返回管线。 另外，该系统可以采用第一返回燃料止回阀来将燃料仅释放到储存器喷射泵和/或转移喷射泵中，而第二返回燃料止回阀可以仅将燃料直接释放到燃料泵模块储存器中。 储存器内的电动燃料泵可以具有燃料泵止回阀，并且仅当燃料返回管线中的压力传感器启动时才向燃料喷射泵和/或转移喷射泵供给燃料，而不向发动机供应燃料。

公开(公告)号：US08689827B2

公开(公告)日：2014-04-08

申请号：US13230027

申请日：2011-09-12

申请人： Tetsuro Okazono ,  Shinobu Oikawa ,  Kiyomori Kobayashi ,  Norihiro Hayashi ,  Shinji Noda ,  Hiroshi Morishita ,  Kazuki Matsubara ,  Kouji Maruyama ,  Masato Inoue ,  Hironobu Oki

发明人： Tetsuro Okazono ,  Shinobu Oikawa ,  Kiyomori Kobayashi ,  Norihiro Hayashi ,  Shinji Noda ,  Hiroshi Morishita ,  Kazuki Matsubara ,  Kouji Maruyama ,  Masato Inoue ,  Hironobu Oki

IPC分类号： F04B17/03 ,  B67D7/68 ,  F02M37/10

CPC分类号： F02M37/106 ,  B01D35/027 ,  B01D35/26 ,  B60K15/077 ,  F02M37/0017 ,  F02M37/025 ,  F02M37/103 ,  F04B23/021 ,  Y10T29/49826 ,  Y10T137/86035 ,  Y10T137/86043 ,  Y10T137/86067 ,  Y10T137/86091

摘要： A support shaft connects between a flange and a pump unit. An intermediate member, which connects between the support shaft and pump unit, enables a relative positional change between the support shaft and the pump unit in an axial direction of the support shaft. The intermediate member limits a relative positional change between the support shaft and the pump unit in a circumferential direction of the support shaft. A resilient member is received in the support shaft and exerts a restoring force in an axial direction of the support shaft to urge the pump unit, which is movable relative to the support shaft in the axial direction, toward a bottom portion of the fuel tank.

摘要翻译： 支撑轴连接在法兰和泵单元之间。 连接在支撑轴和泵单元之间的中间构件能够在支撑轴的轴向方向上支撑轴和泵单元之间的相对位置变化。 中间构件在支撑轴的圆周方向上限制支撑轴和泵单元之间的相对位置变化。 弹性构件被容纳在支撑轴中并且沿着支撑轴的轴向方向施加恢复力，以将相对于支撑轴在轴向方向上移动的泵单元推向燃料箱的底部。