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公开(公告)号：US5348746A
公开(公告)日：1994-09-20
申请号：US964538
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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12.发明授权Osmotic dosage system for delivering a formulation comprising liquid carrier and drug 失效用于递送包含液体载体和药物的制剂的渗透剂量系统
公开(公告)号：US5324280A
公开(公告)日：1994-06-28
申请号：US502705
申请日：1990-04-02
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译： 公开了用于将有益剂制剂递送到使用环境的渗透系统。 渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。
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公开(公告)号：US4892778A
公开(公告)日：1990-01-09
申请号：US054714
申请日：1987-05-27
CPC分类号： A61M31/002 , A61K9/0004 , Y10S428/913 , Y10T428/24992 , Y10T428/31504 , Y10T428/31511 , Y10T428/31909 , Y10T428/31978
摘要： A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
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公开(公告)号：US4857330A
公开(公告)日：1989-08-15
申请号：US176561
申请日：1988-04-01
CPC分类号： A61K9/0004 , A61K31/44
摘要： An osmotic dosage form is disclosed for delivering chlorpheniramine.
摘要翻译： 公开了用于递送氯苯那敏的渗透剂型。
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公开(公告)号：US4851229A
公开(公告)日：1989-07-25
申请号：US150124
申请日：1988-01-29
CPC分类号： A61K9/0004 , A61M31/002
摘要： An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
摘要翻译： 公开了一种渗透递送系统，用于以受控和恒定的速率递送有用的试剂，该有用试剂通过有用试剂的脉冲输送调节到使用环境。
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公开(公告)号：US4847093A
公开(公告)日：1989-07-11
申请号：US668761
申请日：1986-06-19
申请人： Atul D. Ayer , Patrick S. L. Wong
发明人： Atul D. Ayer , Patrick S. L. Wong
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed comprising a release rate controlling wall that surrounds a carbon dioxide generating compound.
摘要翻译： 公开了一种渗透装置，其包括围绕产生二氧化碳的化合物的释放速率控制壁。
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公开(公告)号：US4837111A
公开(公告)日：1989-06-06
申请号：US173524
申请日：1988-03-21
IPC分类号： A61K9/00 , A61K9/22 , A61K9/36 , A61K31/505 , A61P25/02
CPC分类号： A61K9/0004 , A61K31/505
摘要： An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.
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18.发明授权
公开(公告)号：US4824675A
公开(公告)日：1989-04-25
申请号：US72506
申请日：1987-07-13
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
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公开(公告)号：US4755180A
公开(公告)日：1988-07-05
申请号：US874961
申请日：1986-06-16
申请人： Atul D. Ayer , Patrick S. L. Wong
发明人： Atul D. Ayer , Patrick S. L. Wong
CPC分类号： A61M31/002 , A61K9/0004
摘要： An osmotic dosage form is disclosed comprising a polymeric olefin, vinyl, condensation, addition or silicon film that surrounds a member selected from the group consisting of a buffer and osmogent which member is released by the film as a means for governing the solubility of a beneficial agent in the dosage form.
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20.发明授权
公开(公告)号：US4587117A
公开(公告)日：1986-05-06
申请号：US693649
申请日：1985-01-22
申请人： David Edgren , Patrick S. L. Wong , Felix Theeuwes
发明人： David Edgren , Patrick S. L. Wong , Felix Theeuwes
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering a beneficial agent to a first environment having a pH of 1.0 to 3.5 inclusive and to a second environment having a pH of greater than 3.5 to 8.0. The device maintains its integrity in the first environment and loses its integrity in the second environment.
摘要翻译： 公开了一种渗透装置，用于将有益剂递送至pH为1.0至3.5的第一环境，以及pH大于3.5至8.0的第二环境。 该设备在第一个环境中保持其完整性，并在第二个环境中失去其完整性。
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