公开(公告)号：US06998403B2

公开(公告)日：2006-02-14

申请号：US10925712

申请日：2004-08-25

申请人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert ,  Benjamin Di Cara

发明人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert ,  Benjamin Di Cara

IPC分类号： A61K31/496 ,  C07D403/12

CPC分类号： C07D209/60

摘要： A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, and R3 and R4 represent hydrogen, or R1 and R4 represent hydrogen and R2 and R3 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, or R1 and R2 represent hydrogen and R3 and R4 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, addition salts thereof with a pharmaceutically acceptable acid or base, and methods of treating conditions susceptible to α2-AR/5-HT2C antagonists.

摘要翻译： 式（I）化合物：化学式id =“CHEM-US-00001”num =“000

公开(公告)号：US5968954A

公开(公告)日：1999-10-19

申请号：US31490

申请日：1998-02-26

申请人： Jean-Louis Peglion ,  Bertrand Goument ,  Mark Millan ,  Alain Gobert

发明人： Jean-Louis Peglion ,  Bertrand Goument ,  Mark Millan ,  Alain Gobert

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/495 ,  A61P3/04 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D411/04 ,  C07D413/14 ,  C07D491/056 ,  C07D405/12

CPC分类号： C07D405/04 ,  C07D409/04 ,  C07D411/04

摘要： New 2-aminoindan compounds of formula: ##STR1## wherein: n, Ar, R, E, X.sub.1, X.sub.2, X.sub.3, and X.sub.4 are as defined in the description, in the form of a racemic mixture and in the form of optical isomers, and physiologically-tolerable acid addition salts thereof. The products of the invention are useful as medicaments and exhibit selective binding affinity for the 5HT.sub.1B receptors.

摘要翻译： 新的2-氨基茚满化合物其中：n，Ar，R，E，X 1，X 2，X 3和X 4如说明书中所定义，以外消旋混合物的形式，以旋光异构体的形式和生理学上 其耐受酸加成盐。 本发明的产品可用作药物并且显示出对5HT1B受体的选择性结合亲和力。